位置:首页 > 蛋白库 > CDH_SALEP
CDH_SALEP
ID   CDH_SALEP               Reviewed;         251 AA.
AC   B5QWZ7;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-NOV-2008, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=CDP-diacylglycerol pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_00319};
DE            EC=3.6.1.26 {ECO:0000255|HAMAP-Rule:MF_00319};
DE   AltName: Full=CDP-diacylglycerol phosphatidylhydrolase {ECO:0000255|HAMAP-Rule:MF_00319};
DE   AltName: Full=CDP-diglyceride hydrolase {ECO:0000255|HAMAP-Rule:MF_00319};
GN   Name=cdh {ECO:0000255|HAMAP-Rule:MF_00319}; OrderedLocusNames=SEN3854;
OS   Salmonella enteritidis PT4 (strain P125109).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=550537;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P125109;
RX   PubMed=18583645; DOI=10.1101/gr.077404.108;
RA   Thomson N.R., Clayton D.J., Windhorst D., Vernikos G., Davidson S.,
RA   Churcher C., Quail M.A., Stevens M., Jones M.A., Watson M., Barron A.,
RA   Layton A., Pickard D., Kingsley R.A., Bignell A., Clark L., Harris B.,
RA   Ormond D., Abdellah Z., Brooks K., Cherevach I., Chillingworth T.,
RA   Woodward J., Norberczak H., Lord A., Arrowsmith C., Jagels K., Moule S.,
RA   Mungall K., Saunders M., Whitehead S., Chabalgoity J.A., Maskell D.,
RA   Humphreys T., Roberts M., Barrow P.A., Dougan G., Parkhill J.;
RT   "Comparative genome analysis of Salmonella enteritidis PT4 and Salmonella
RT   gallinarum 287/91 provides insights into evolutionary and host adaptation
RT   pathways.";
RL   Genome Res. 18:1624-1637(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a CDP-1,2-diacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycero-
CC         3-phosphate + CMP + 2 H(+); Xref=Rhea:RHEA:15221, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58332, ChEBI:CHEBI:58608,
CC         ChEBI:CHEBI:60377; EC=3.6.1.26; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00319};
CC   -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol degradation;
CC       phosphatidate from CDP-diacylglycerol: step 1/1. {ECO:0000255|HAMAP-
CC       Rule:MF_00319}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00319}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00319}.
CC   -!- SIMILARITY: Belongs to the Cdh family. {ECO:0000255|HAMAP-
CC       Rule:MF_00319}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM933172; CAR35427.1; -; Genomic_DNA.
DR   RefSeq; WP_000750762.1; NC_011294.1.
DR   AlphaFoldDB; B5QWZ7; -.
DR   SMR; B5QWZ7; -.
DR   KEGG; set:SEN3854; -.
DR   HOGENOM; CLU_077117_0_1_6; -.
DR   OMA; SPFIMLA; -.
DR   UniPathway; UPA00609; UER00664.
DR   Proteomes; UP000000613; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008715; F:CDP-diacylglycerol diphosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046342; P:CDP-diacylglycerol catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.428.30; -; 1.
DR   HAMAP; MF_00319; Cdh; 1.
DR   InterPro; IPR003763; CDP-diacylglyc_Pase.
DR   InterPro; IPR015993; CDP-diacylglyc_Pase_proteobac.
DR   InterPro; IPR036265; HIT-like_sf.
DR   Pfam; PF02611; CDH; 1.
DR   PIRSF; PIRSF001273; CDH; 1.
DR   SUPFAM; SSF54197; SSF54197; 1.
DR   TIGRFAMs; TIGR00672; cdh; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Hydrolase; Lipid biosynthesis;
KW   Lipid metabolism; Membrane; Phospholipid biosynthesis;
KW   Phospholipid metabolism; Transmembrane; Transmembrane helix.
FT   CHAIN           1..251
FT                   /note="CDP-diacylglycerol pyrophosphatase"
FT                   /id="PRO_1000115944"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00319"
SQ   SEQUENCE   251 AA;  28334 MW;  2F4BBAB9F6B870BE CRC64;
     MKKTGYFLLA VIVIVAAAGV GYWKFSGNPD ALREIVLEQC LPDQLQHQNP APCAEVKPRA
     GYVVFKDRHG PLQYLLMPTY RINGTESPLL LEPATPNFFW LAWQARGYMS KKYGHDIPDS
     AVSLAINSRL GRSQDHLHIH ISCIRPDVRE QLDNDLTRIS TRWLPLPGGL MGHEYLARRV
     TESELAQRSP FMMLAEEVPE ARDHMGRYAL AVVRQSDDSF VLLATERNLL TLNRASAEEI
     QDHSCAILSS R
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024