CDH_YERPE
ID CDH_YERPE Reviewed; 258 AA.
AC Q8ZA34; Q0WA32;
DT 20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 116.
DE RecName: Full=CDP-diacylglycerol pyrophosphatase;
DE EC=3.6.1.26;
DE AltName: Full=CDP-diacylglycerol phosphatidylhydrolase;
DE AltName: Full=CDP-diglyceride hydrolase;
GN Name=cdh; OrderedLocusNames=YPO3986, y3843, YP_3349;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a CDP-1,2-diacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycero-
CC 3-phosphate + CMP + 2 H(+); Xref=Rhea:RHEA:15221, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58332, ChEBI:CHEBI:58608,
CC ChEBI:CHEBI:60377; EC=3.6.1.26;
CC -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol degradation;
CC phosphatidate from CDP-diacylglycerol: step 1/1.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Single-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Cdh family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM87388.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAS63514.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL590842; CAL22566.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM87388.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE017042; AAS63514.1; ALT_INIT; Genomic_DNA.
DR PIR; AC0485; AC0485.
DR RefSeq; YP_002348856.1; NC_003143.1.
DR AlphaFoldDB; Q8ZA34; -.
DR SMR; Q8ZA34; -.
DR IntAct; Q8ZA34; 1.
DR STRING; 214092.YPO3986; -.
DR PaxDb; Q8ZA34; -.
DR DNASU; 1148790; -.
DR EnsemblBacteria; AAM87388; AAM87388; y3843.
DR EnsemblBacteria; AAS63514; AAS63514; YP_3349.
DR KEGG; ype:YPO3986; -.
DR KEGG; ypk:y3843; -.
DR KEGG; ypm:YP_3349; -.
DR PATRIC; fig|214092.21.peg.4519; -.
DR eggNOG; COG2134; Bacteria.
DR HOGENOM; CLU_077117_0_1_6; -.
DR UniPathway; UPA00609; UER00664.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008715; F:CDP-diacylglycerol diphosphatase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046342; P:CDP-diacylglycerol catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.428.30; -; 1.
DR HAMAP; MF_00319; Cdh; 1.
DR InterPro; IPR003763; CDP-diacylglyc_Pase.
DR InterPro; IPR036265; HIT-like_sf.
DR Pfam; PF02611; CDH; 1.
DR PIRSF; PIRSF001273; CDH; 1.
DR SUPFAM; SSF54197; SSF54197; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Hydrolase; Lipid biosynthesis;
KW Lipid metabolism; Membrane; Phospholipid biosynthesis;
KW Phospholipid metabolism; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..258
FT /note="CDP-diacylglycerol pyrophosphatase"
FT /id="PRO_0000198584"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 258 AA; 28779 MW; 270AB6432698A446 CRC64;
MSRSIKWRRY LLTLLILIIL AAGLIYKLRF SNADALWKII SQQCIPHMTT EDDPRPCAEV
NIPAGFAVLK DRNGPLQYLL IPTVPISGIE SPQLLTATSP NYFADAWQAR YFMAEKYGAP
IDDTDISLAI NSQYGRTQDQ LHIHISCLKP QVKTALAAHS ADFQQQWQPL PGGLLGHDYW
VRRITATELQ QPGPFHLLAD EMPGAKEQMG RYGLAITALP SGDFLLLANK ASLITQDRAS
AEELQDHTCQ VLPHLPVQ
