ID   CDIB2_BURP2             Reviewed;         584 AA.
AC   P0DMJ8;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   09-JUL-2014, sequence version 1.
DT   03-AUG-2022, entry version 23.
DE   RecName: Full=Outer membrane transporter CdiB-2;
DE            Short=CdiB-2;
DE   AltName: Full=CdiB-II;
DE   Flags: Precursor;
GN   Name=cdiB2; OrderedLocusNames=BP1026B_II2204;
OS   Burkholderia pseudomallei (strain 1026b).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=884204;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1026b;
RX   PubMed=22615773; DOI=10.1371/journal.pone.0036507;
RA   Hayden H.S., Lim R., Brittnacher M.J., Sims E.H., Ramage E.R., Fong C.,
RA   Wu Z., Crist E., Chang J., Zhou Y., Radey M., Rohmer L., Haugen E.,
RA   Gillett W., Wuthiekanun V., Peacock S.J., Kaul R., Miller S.I., Manoil C.,
RA   Jacobs M.A.;
RT   "Evolution of Burkholderia pseudomallei in recurrent melioidosis.";
RL   PLoS ONE 7:E36507-E36507(2012).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=1026b;
RX   PubMed=22435733; DOI=10.1111/j.1365-2958.2012.08039.x;
RA   Nikolakakis K., Amber S., Wilbur J.S., Diner E.J., Aoki S.K., Poole S.J.,
RA   Tuanyok A., Keim P.S., Peacock S., Hayes C.S., Low D.A.;
RT   "The toxin/immunity network of Burkholderia pseudomallei contact-dependent
RT   growth inhibition (CDI) systems.";
RL   Mol. Microbiol. 84:516-529(2012).
CC   -!- FUNCTION: Potential outer membrane protein component of a toxin-
CC       immunity protein module, which functions as a cellular contact-
CC       dependent growth inhibition (CDI) system. CDI modules allow bacteria to
CC       communicate with and inhibit the growth of closely related neighboring
CC       bacteria in a contact-dependent fashion. This protein may be required
CC       for secretion and assembly of the CdiA toxin protein.
CC       {ECO:0000269|PubMed:22435733}.
CC   -!- FUNCTION: Expression of this cdiAIB locus in B.thailandensis confers
CC       protection against other bacteria carrying the locus; growth inhibition
CC       requires cellular contact. {ECO:0000269|PubMed:22435733}.
CC   -!- FUNCTION: Probable member of a two partner secretion pathway (TPS) in
CC       which it mediates the secretion of CdiA2. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Deletion of this gene from the locus expressed in
CC       B.thailandensis abrogates growth inhibition.
CC       {ECO:0000269|PubMed:22435733}.
CC   -!- SIMILARITY: Belongs to the TPS (TC 1.B.20) family.
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DR   EMBL; CP002834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; WP_038742387.1; NZ_CP004380.1.
DR   AlphaFoldDB; P0DMJ8; -.
DR   SMR; P0DMJ8; -.
DR   TCDB; 1.B.20.1.10; the two-partner secretion (tps) family.
DR   Proteomes; UP000010087; Chromosome 2.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR005565; Hemolysn_activator_HlyB_C.
DR   InterPro; IPR013686; Polypept-transport_assoc_ShlB.
DR   InterPro; IPR034746; POTRA.
DR   InterPro; IPR035251; ShlB_POTRA.
DR   InterPro; IPR027282; TPS.
DR   Pfam; PF08479; POTRA_2; 1.
DR   Pfam; PF17287; POTRA_3; 1.
DR   Pfam; PF03865; ShlB; 1.
DR   PIRSF; PIRSF029745; FhaC; 1.
DR   PROSITE; PS51779; POTRA; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Ion transport; Membrane; Porin; Protein transport;
KW   Signal; Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..584
FT                   /note="Outer membrane transporter CdiB-2"
FT                   /id="PRO_0000429696"
FT   DOMAIN          98..171
FT                   /note="POTRA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01115"
FT   REGION          24..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..52
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   584 AA;  63654 MW;  34F0370186BE07A3 CRC64;
     MATRFAILPV TALITLTAQA QQAPTPNDQA AAARANAEQN QQAQQRRDAQ QRDATVQAPG
     VRSDVPRPEA YPVLPTETPC FQIDRFALDV PDSLPAASKA QGASALPMDR FAFARDWLAH
     YAGQCIGKQG VDLIVKGLSQ AILARGYITT RVLVPEQDLS TGALKLALIP GVIRHVRFED
     EKLLGTWKTA FPTRDGDVLN LRDIEQGLEQ MKRVSSQDVS MRIAPGDMPG ESDVVLDVKR
     GKPWTVVASI DNSGTRATGK LQGNVSLGID NPLGLNDIFN VGFNQDLEFG DKRFGSHGWN
     AFYSIPWGYW TGTLSAYTST YFQPLAAVNQ TFVASGNMKT VDFRLNRVLT RSRNDVLGAQ
     VRLTRRFGDS YIEGTTIPSS HQNATFLEFG LNDRHYFGSS QFDGSLAYRQ GLGWLGSTDS
     MFAAEGGQTY RFKMVVLDAN LSTPFVIGTQ PFKYVTTFHG QYTGNTVSYL DSVTIGSRYT
     VRGFDGETLL AGSRGFYWRN ELQVPVAQTG LSAYAGLDYG RVWGPEPVAL VGTQLAGAVI
     GVKGSLMTRF GGYGYDLFAG TPVYKPSGFP TARVTVGFQL TAQF