ID   CDIB_ECOL5              Reviewed;         588 AA.
AC   Q0T962;
DT   04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Outer membrane transporter CdiB {ECO:0000305};
GN   Name=cdiB {ECO:0000303|PubMed:21085179}; OrderedLocusNames=ECP_4581;
OS   Escherichia coli O6:K15:H31 (strain 536 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=362663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=536 / UPEC;
RX   PubMed=16879640; DOI=10.1111/j.1365-2958.2006.05255.x;
RA   Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U.,
RA   Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J.;
RT   "Role of pathogenicity island-associated integrases in the genome
RT   plasticity of uropathogenic Escherichia coli strain 536.";
RL   Mol. Microbiol. 61:584-595(2006).
RN   [2]
RP   FUNCTION.
RC   STRAIN=536 / UPEC;
RX   PubMed=21085179; DOI=10.1038/nature09490;
RA   Aoki S.K., Diner E.J., de Roodenbeke C.T., Burgess B.R., Poole S.J.,
RA   Braaten B.A., Jones A.M., Webb J.S., Hayes C.S., Cotter P.A., Low D.A.;
RT   "A widespread family of polymorphic contact-dependent toxin delivery
RT   systems in bacteria.";
RL   Nature 468:439-442(2010).
CC   -!- FUNCTION: Potential outer membrane protein component of a toxin-
CC       immunity protein module, which functions as a cellular contact-
CC       dependent growth inhibition (CDI) system. CDI modules allow bacteria to
CC       communicate with and inhibit the growth of closely related neighboring
CC       bacteria in a contact-dependent fashion. This protein may be required
CC       for secretion and assembly of the CdiA toxin protein.
CC       {ECO:0000305|PubMed:21085179}.
CC   -!- FUNCTION: Probable member of a two partner secretion pathway (TPS) in
CC       which it mediates the secretion of CdiA. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000305|PubMed:21085179}.
CC   -!- SIMILARITY: Belongs to the TPS (TC 1.B.20) family. {ECO:0000305}.
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DR   EMBL; CP000247; ABG72517.1; -; Genomic_DNA.
DR   RefSeq; WP_001164766.1; NC_008253.1.
DR   AlphaFoldDB; Q0T962; -.
DR   SMR; Q0T962; -.
DR   STRING; 362663.ECP_4581; -.
DR   EnsemblBacteria; ABG72517; ABG72517; ECP_4581.
DR   KEGG; ecp:ECP_4581; -.
DR   HOGENOM; CLU_020581_4_1_6; -.
DR   OMA; GLNHTQK; -.
DR   Proteomes; UP000009182; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR005565; Hemolysn_activator_HlyB_C.
DR   InterPro; IPR013686; Polypept-transport_assoc_ShlB.
DR   InterPro; IPR034746; POTRA.
DR   InterPro; IPR035251; ShlB_POTRA.
DR   InterPro; IPR027282; TPS.
DR   Pfam; PF08479; POTRA_2; 1.
DR   Pfam; PF17287; POTRA_3; 1.
DR   Pfam; PF03865; ShlB; 1.
DR   PIRSF; PIRSF029745; FhaC; 1.
DR   PROSITE; PS51779; POTRA; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Protein transport; Transmembrane;
KW   Transmembrane beta strand; Transmembrane helix; Transport.
FT   CHAIN           1..588
FT                   /note="Outer membrane transporter CdiB"
FT                   /id="PRO_0000432083"
FT   TRANSMEM        33..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          104..179
FT                   /note="POTRA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01115"
SQ   SEQUENCE   588 AA;  64705 MW;  3FBFE8C18785D9CA CRC64;
     MQHRQDNLLA NRNLLPGMVS GQYAFRIRTL SQVVRYFSLL PCLCILSFSS PAAMLSPGDR
     SAIQQQQQQL LDENQRQRDA LERSAPLTIT PSPETSAGTE GPCFTVSRIV VSGATRLTSA
     ETDRLVAPWV NQCLNITGLT AVTDAVTDGY IRRGYITSRA FLTEQDLSGG VLHITVMEGR
     LQQIRAEGAD LPGRTLKMVF PGMEGKVLNL RDIEQGMEQI NRLRTESVQI EISPGDREGW
     SVVTLTALPE WPVTGSVGID NSGQKNTGTG QLNGVLSFNN PLGLADNWFV RGGRSSDFSV
     SHDARNFAAG VSLPYGYTLV DYTYSWSDYL STIDNRGWLW RSTGDLQTHR LGLSHVLFRN
     GNMKTALTGG LQHRIIHNYL DDVLLQGSSR KLTSFSVGLN HTHKFLGGVG TLNPVFTRGM
     PWFGAESDHG KRGDLPVNQF RKWSVSASFQ RPVTDRVWWL TSAYAQWSPD RLHGVEQLSL
     GGESSVRGFK EQYISGNNGG YLRNELSWSL FSLPYVGTVR AVTALDGGWL HSDRDDPYSS
     GTLWGAAAGL STTSGHVSGS FTAGLPLVYP DWLAPDHLTV YWRVAVAF