ID   CDII1_ECO5C             Reviewed;          86 AA.
AC   A0A0H3PIP6;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-SEP-2015, sequence version 1.
DT   03-AUG-2022, entry version 9.
DE   RecName: Full=Immunity protein CdiI-1;
DE            Short=CdiI-EC869;
GN   Name=cdiI1 {ECO:0000305}; ORFNames=ECH7EC869_5849;
OS   Escherichia coli O157:H7 (strain EC869).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=478008;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EC869;
RX   PubMed=21421787; DOI=10.1128/aem.02554-10;
RA   Eppinger M., Mammel M.K., Leclerc J.E., Ravel J., Cebula T.A.;
RT   "Genome signatures of Escherichia coli O157:H7 isolates from the bovine
RT   host reservoir.";
RL   Appl. Environ. Microbiol. 77:2916-2925(2011).
RN   [2]
RP   FUNCTION.
RC   STRAIN=EC869;
RX   PubMed=28223500; DOI=10.1073/pnas.1619273114;
RA   Jones A.M., Garza-Sanchez F., So J., Hayes C.S., Low D.A.;
RT   "Activation of contact-dependent antibacterial tRNase toxins by translation
RT   elongation factors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 114:E1951-E1957(2017).
CC   -!- FUNCTION: Immunity protein component of a toxin-immunity protein
CC       module, which functions as a cellular contact-dependent growth
CC       inhibition (CDI) system. CDI modules allow bacteria to communicate with
CC       and inhibit the growth of closely related neighboring bacteria in a
CC       contact-dependent fashion. Neutralizes the toxic activity of cognate
CC       toxin CdiA-EC869 (the C-terminal 289 residue CT fragment). Does not
CC       inhibit toxic activity of CdiA from other toxin-immunity modules or
CC       strains of E.coli. {ECO:0000269|PubMed:28223500}.
CC   -!- SUBUNIT: Interacts with the C-terminal fragment (CT) of cognate toxin
CC       protein CdiA-EC869. {ECO:0000305|PubMed:28223500}.
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DR   EMBL; ABHU01000020; EDU89568.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0H3PIP6; -.
DR   EnsemblBacteria; EDU89568; EDU89568; ECH7EC869_5849.
DR   BioCyc; ECOL478008-HMP:G76-483089-MON; -.
DR   Proteomes; UP000004641; Unassembled WGS sequence.
PE   4: Predicted;
FT   CHAIN           1..86
FT                   /note="Immunity protein CdiI-1"
FT                   /id="PRO_0000447225"
SQ   SEQUENCE   86 AA;  9825 MW;  20FE3606374DD741 CRC64;
     MNTKLWSHSE SDDFSRRFVD DFSLDIEVII SSESMLLTIG ENKKVTSWIK CSDNFYLGID
     AGRNVVHLYL DKLTPSEVES FFEAVG