ID   CDII2_BURP2             Reviewed;         101 AA.
AC   P0DMJ7;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   09-JUL-2014, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=Immunity protein CdiI-2;
DE   AltName: Full=Immunity protein CdiI-II;
GN   Name=cdiI2; OrderedLocusNames=BP1026B_II2206.1;
OS   Burkholderia pseudomallei (strain 1026b).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=884204;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1026b;
RX   PubMed=22615773; DOI=10.1371/journal.pone.0036507;
RA   Hayden H.S., Lim R., Brittnacher M.J., Sims E.H., Ramage E.R., Fong C.,
RA   Wu Z., Crist E., Chang J., Zhou Y., Radey M., Rohmer L., Haugen E.,
RA   Gillett W., Wuthiekanun V., Peacock S.J., Kaul R., Miller S.I., Manoil C.,
RA   Jacobs M.A.;
RT   "Evolution of Burkholderia pseudomallei in recurrent melioidosis.";
RL   PLoS ONE 7:E36507-E36507(2012).
RN   [2]
RP   FUNCTION, INTERACTION WITH CDIA, SUBUNIT, AND EXPRESSION IN E.COLI.
RC   STRAIN=1026b;
RX   PubMed=22435733; DOI=10.1111/j.1365-2958.2012.08039.x;
RA   Nikolakakis K., Amber S., Wilbur J.S., Diner E.J., Aoki S.K., Poole S.J.,
RA   Tuanyok A., Keim P.S., Peacock S., Hayes C.S., Low D.A.;
RT   "The toxin/immunity network of Burkholderia pseudomallei contact-dependent
RT   growth inhibition (CDI) systems.";
RL   Mol. Microbiol. 84:516-529(2012).
RN   [3]
RP   FUNCTION.
RC   STRAIN=1026b;
RX   PubMed=25174572; DOI=10.1111/mmi.12779;
RA   Ruhe Z.C., Nguyen J.Y., Beck C.M., Low D.A., Hayes C.S.;
RT   "The proton-motive force is required for translocation of CDI toxins across
RT   the inner membrane of target bacteria.";
RL   Mol. Microbiol. 94:466-481(2014).
RN   [4]
RP   X-RAY CRYSTALLOGRAPHY (2.64 ANGSTROMS) IN COMPLEX WITH CDIA, AND SUBUNIT.
RC   STRAIN=1026b;
RX   PubMed=23236156; DOI=10.1073/pnas.1216238110;
RA   Morse R.P., Nikolakakis K.C., Willett J.L., Gerrick E., Low D.A.,
RA   Hayes C.S., Goulding C.W.;
RT   "Structural basis of toxicity and immunity in contact-dependent growth
RT   inhibition (CDI) systems.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:21480-21485(2012).
CC   -!- FUNCTION: Immunity protein component of a toxin-immunity protein
CC       module, which functions as a cellular contact-dependent growth
CC       inhibition (CDI) system. CDI modules allow bacteria to communicate with
CC       and inhibit the growth of closely related neighboring bacteria in a
CC       contact-dependent fashion. Neutralizes the toxic activity of cognate
CC       toxin CdiA (C-terminal 301 residue CT fragment) upon expression in
CC       E.coli. Does not inhibit toxic activity of CdiA from other strains of
CC       B.pseudomallei. {ECO:0000269|PubMed:22435733,
CC       ECO:0000269|PubMed:25174572}.
CC   -!- FUNCTION: Expression of this cdiAIB locus in B.thailandensis confers
CC       protection against other bacteria carrying the locus; growth inhibition
CC       requires cellular contact. {ECO:0000269|PubMed:22435733}.
CC   -!- SUBUNIT: Specifically interacts with the truncated CT fragment of
CC       cognate toxin protein CdiA-2, which inhibits CdiA-2 tRNA nuclease
CC       activity. {ECO:0000269|PubMed:22435733, ECO:0000269|PubMed:23236156}.
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DR   EMBL; CP002834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PDB; 4G6V; X-ray; 2.64 A; B/D/F/H=1-101.
DR   PDBsum; 4G6V; -.
DR   AlphaFoldDB; P0DMJ7; -.
DR   SMR; P0DMJ7; -.
DR   Proteomes; UP000010087; Chromosome 2.
DR   CDD; cd13443; CDI_inhibitor_Bp1026b_like; 1.
DR   InterPro; IPR033805; CdiI_Bp1026b-like.
PE   1: Evidence at protein level;
KW   3D-structure.
FT   CHAIN           1..101
FT                   /note="Immunity protein CdiI-2"
FT                   /id="PRO_0000429694"
SQ   SEQUENCE   101 AA;  11203 MW;  B7ED2F1C2CE53AA4 CRC64;
     MAIDLFCYLS IDRGAAESDL NKIRSNHSEL FEGKFLISPV RDADFSLKEI AAEHGLVAES
     FFLVSLNDKN SADLIPIVSK ILVDGFNGGA ILILQDNEYR R