ID   CDII8_BURPE             Reviewed;         109 AA.
AC   H9T8I0;
DT   03-SEP-2014, integrated into UniProtKB/Swiss-Prot.
DT   03-SEP-2014, sequence version 1.
DT   25-MAY-2022, entry version 17.
DE   RecName: Full=Immunity protein CdiI;
GN   Name=cdiI;
OS   Burkholderia pseudomallei (Pseudomonas pseudomallei).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=28450;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=E478;
RX   PubMed=18299706; DOI=10.1371/journal.pntd.0000182;
RA   Chantratita N., Wuthiekanun V., Limmathurotsakul D., Vesaratchavest M.,
RA   Thanwisai A., Amornchai P., Tumapa S., Feil E.J., Day N.P., Peacock S.J.;
RT   "Genetic diversity and microevolution of Burkholderia pseudomallei in the
RT   environment.";
RL   PLoS Negl. Trop. Dis. 2:E182-E182(2008).
RN   [2]
RP   FUNCTION, INTERACTION WITH CDIA, AND SUBUNIT.
RC   STRAIN=E478;
RX   PubMed=22435733; DOI=10.1111/j.1365-2958.2012.08039.x;
RA   Nikolakakis K., Amber S., Wilbur J.S., Diner E.J., Aoki S.K., Poole S.J.,
RA   Tuanyok A., Keim P.S., Peacock S., Hayes C.S., Low D.A.;
RT   "The toxin/immunity network of Burkholderia pseudomallei contact-dependent
RT   growth inhibition (CDI) systems.";
RL   Mol. Microbiol. 84:516-529(2012).
CC   -!- FUNCTION: Immunity protein component of a toxin-immunity protein
CC       module, which functions as a cellular contact-dependent growth
CC       inhibition (CDI) system. CDI modules allow bacteria to communicate with
CC       and inhibit the growth of closely related neighboring bacteria in a
CC       contact-dependent fashion. Neutralizes the toxic activity of cognate
CC       toxin CdiA (C-terminal 282 residue CT fragment) upon expression in
CC       E.coli. Does not inhibit toxic activity of CdiA from other strains of
CC       B.pseudomallei. {ECO:0000269|PubMed:22435733}.
CC   -!- SUBUNIT: Specifically interacts with cognate toxin CdiA, which inhibits
CC       the toxin. {ECO:0000269|PubMed:22435733}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JQ423913; AFG17279.1; -; Genomic_DNA.
DR   RefSeq; WP_009941131.1; NZ_WUTV01000013.1.
DR   AlphaFoldDB; H9T8I0; -.
DR   SMR; H9T8I0; -.
DR   GO; GO:0030153; P:bacteriocin immunity; IEA:InterPro.
DR   Gene3D; 3.30.190.30; -; 1.
DR   InterPro; IPR020127; Colicin-E5_imm.
DR   InterPro; IPR037234; ImmE5_sf.
DR   Pfam; PF11480; ImmE5; 1.
DR   SUPFAM; SSF143469; SSF143469; 1.
PE   1: Evidence at protein level;
FT   CHAIN           1..109
FT                   /note="Immunity protein CdiI"
FT                   /id="PRO_0000429993"
SQ   SEQUENCE   109 AA;  11891 MW;  580CB882600FF16E CRC64;
     MNIDLQRRYD SSDDFFSLGG SVVMKLSADA AIAVCERAGQ HGLVVARIEG GIWHFPGFEA
     RLDCIWDGID PPVDVGVAEQ NNLAAAEFVR SESQEHDVFV VTAPEITGW