ID   CDII9_BURPE             Reviewed;         109 AA.
AC   H9T8G7;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2012, sequence version 1.
DT   25-MAY-2022, entry version 14.
DE   RecName: Full=Immunity protein CdiI;
DE   AltName: Full=CdiI-E479;
GN   Name=cdiI;
OS   Burkholderia pseudomallei (Pseudomonas pseudomallei).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=28450;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=E479;
RX   PubMed=18299706; DOI=10.1371/journal.pntd.0000182;
RA   Chantratita N., Wuthiekanun V., Limmathurotsakul D., Vesaratchavest M.,
RA   Thanwisai A., Amornchai P., Tumapa S., Feil E.J., Day N.P., Peacock S.J.;
RT   "Genetic diversity and microevolution of Burkholderia pseudomallei in the
RT   environment.";
RL   PLoS Negl. Trop. Dis. 2:E182-E182(2008).
RN   [2]
RP   FUNCTION, INTERACTION WITH CDIA, AND SUBUNIT.
RC   STRAIN=E479;
RX   PubMed=22435733; DOI=10.1111/j.1365-2958.2012.08039.x;
RA   Nikolakakis K., Amber S., Wilbur J.S., Diner E.J., Aoki S.K., Poole S.J.,
RA   Tuanyok A., Keim P.S., Peacock S., Hayes C.S., Low D.A.;
RT   "The toxin/immunity network of Burkholderia pseudomallei contact-dependent
RT   growth inhibition (CDI) systems.";
RL   Mol. Microbiol. 84:516-529(2012).
RN   [3] {ECO:0007744|PDB:5J4A}
RP   X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH CDIA-CT-E479,
RP   FUNCTION, AND SUBUNIT.
RC   STRAIN=E479;
RX   PubMed=27445337; DOI=10.1074/jbc.m116.736074;
RA   Johnson P.M., Gucinski G.C., Garza-Sanchez F., Wong T., Hung L.W.,
RA   Hayes C.S., Goulding C.W.;
RT   "Functional diversity of cytotoxic tRNase/immunity protein complexes from
RT   Burkholderia pseudomallei.";
RL   J. Biol. Chem. 291:19387-19400(2016).
CC   -!- FUNCTION: Immunity protein component of a toxin-immunity protein
CC       module, which functions as a cellular contact-dependent growth
CC       inhibition (CDI) system. CDI modules allow bacteria to communicate with
CC       and inhibit the growth of closely related neighboring bacteria in a
CC       contact-dependent fashion. Neutralizes the toxic activity of cognate
CC       toxin CdiA (C-terminal 160 residue CT fragment) upon expression in
CC       E.coli. Does not inhibit toxic activity of CdiA from other strains of
CC       B.pseudomallei. {ECO:0000269|PubMed:22435733,
CC       ECO:0000269|PubMed:27445337}.
CC   -!- SUBUNIT: Specifically interacts with cognate toxin CdiA, which inhibits
CC       the toxin. {ECO:0000269|PubMed:22435733, ECO:0000269|PubMed:27445337}.
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DR   EMBL; JQ423914; AFG17281.1; -; Genomic_DNA.
DR   PDB; 5J4A; X-ray; 2.00 A; B/D=1-109.
DR   PDBsum; 5J4A; -.
DR   AlphaFoldDB; H9T8G7; -.
DR   SMR; H9T8G7; -.
PE   1: Evidence at protein level;
KW   3D-structure.
FT   CHAIN           1..109
FT                   /note="Immunity protein CdiI"
FT                   /id="PRO_0000429695"
FT   STRAND          3..8
FT                   /evidence="ECO:0007829|PDB:5J4A"
FT   STRAND          11..15
FT                   /evidence="ECO:0007829|PDB:5J4A"
FT   HELIX           17..28
FT                   /evidence="ECO:0007829|PDB:5J4A"
FT   HELIX           33..35
FT                   /evidence="ECO:0007829|PDB:5J4A"
FT   HELIX           36..47
FT                   /evidence="ECO:0007829|PDB:5J4A"
FT   STRAND          52..55
FT                   /evidence="ECO:0007829|PDB:5J4A"
FT   HELIX           61..79
FT                   /evidence="ECO:0007829|PDB:5J4A"
FT   HELIX           84..99
FT                   /evidence="ECO:0007829|PDB:5J4A"
FT   HELIX           102..104
FT                   /evidence="ECO:0007829|PDB:5J4A"
SQ   SEQUENCE   109 AA;  12139 MW;  CE7E3FEC26799C9B CRC64;
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