ID   CDII_ECOLX              Reviewed;          79 AA.
AC   Q3YL95;
DT   04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 16.
DE   RecName: Full=Immunity protein CdiI {ECO:0000303|PubMed:16109881};
GN   Name=cdiI {ECO:0000303|PubMed:16109881};
OS   Escherichia coli.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=EC93;
RX   PubMed=16109881; DOI=10.1126/science.1115109;
RA   Aoki S.K., Pamma R., Hernday A.D., Bickham J.E., Braaten B.A., Low D.A.;
RT   "Contact-dependent inhibition of growth in Escherichia coli.";
RL   Science 309:1245-1248(2005).
RN   [2]
RP   FUNCTION.
RC   STRAIN=EC93;
RX   PubMed=19124575; DOI=10.1128/jb.01437-08;
RA   Aoki S.K., Webb J.S., Braaten B.A., Low D.A.;
RT   "Contact-dependent growth inhibition causes reversible metabolic
RT   downregulation in Escherichia coli.";
RL   J. Bacteriol. 191:1777-1786(2009).
RN   [3]
RP   FUNCTION, AND STRAIN SPECIFICITY.
RC   STRAIN=EC93;
RX   PubMed=21085179; DOI=10.1038/nature09490;
RA   Aoki S.K., Diner E.J., de Roodenbeke C.T., Burgess B.R., Poole S.J.,
RA   Braaten B.A., Jones A.M., Webb J.S., Hayes C.S., Cotter P.A., Low D.A.;
RT   "A widespread family of polymorphic contact-dependent toxin delivery
RT   systems in bacteria.";
RL   Nature 468:439-442(2010).
RN   [4]
RP   FUNCTION, AND STRAIN SPECIFICITY.
RC   STRAIN=EC93;
RX   PubMed=23882017; DOI=10.1128/mbio.00480-13;
RA   Ruhe Z.C., Wallace A.B., Low D.A., Hayes C.S.;
RT   "Receptor polymorphism restricts contact-dependent growth inhibition to
RT   members of the same species.";
RL   MBio 4:E00480-E00480(2013).
CC   -!- FUNCTION: Immunity protein component of a toxin-immunity protein
CC       module, which functions as a cellular contact-dependent growth
CC       inhibition (CDI) system. CDI modules allow bacteria to communicate with
CC       and inhibit the growth of closely related neighboring bacteria in a
CC       contact-dependent fashion. Protects cells against CdiA from the same
CC       strain, its cognate toxin protein (PubMed:16109881, PubMed:23882017).
CC       Growth inhibition is reversible upon induction of this protein,
CC       occurring about 2.5 hours after induction, and requires an energy
CC       source (PubMed:19124575). Does not protect against non-cognate CdiA
CC       from E.coli strain 563 / UPEC, D.dadantii strain 3937 or Y.pestis
CC       strain CO92 (PubMed:21085179). {ECO:0000269|PubMed:16109881,
CC       ECO:0000269|PubMed:19124575, ECO:0000269|PubMed:21085179,
CC       ECO:0000269|PubMed:23882017}.
CC   -!- SUBUNIT: Probably interacts with cognate toxin CdiA.
CC       {ECO:0000305|PubMed:23882017}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255}; Multi-pass
CC       membrane protein {ECO:0000255}.
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DR   EMBL; DQ100454; AAZ57199.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q3YL95; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..79
FT                   /note="Immunity protein CdiI"
FT                   /id="PRO_0000432079"
FT   TRANSMEM        12..32
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        51..71
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   79 AA;  8856 MW;  219A61E25597A94F CRC64;
     MKKKLFALLK YIIFFPMLCT VLGLLGIPIG LIVNFLRTGS FDFNLKDEID VVLFTLKIGI
     PIGFILGLGL WGLSILDRK