ID   CDII_ENTCC              Reviewed;         145 AA.
AC   A0A023GPJ0;
DT   04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT   04-MAR-2015, sequence version 2.
DT   25-MAY-2022, entry version 24.
DE   RecName: Full=Immunity protein CdiI {ECO:0000303|PubMed:24657090};
GN   Name=cdiI {ECO:0000303|PubMed:24657090};
GN   OrderedLocusNames=ECL_04450.1 {ECO:0000305};
OS   Enterobacter cloacae subsp. cloacae (strain ATCC 13047 / DSM 30054 / NBRC
OS   13535 / NCTC 10005 / WDCM 00083 / NCDC 279-56).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Enterobacter; Enterobacter cloacae complex.
OX   NCBI_TaxID=716541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13047 / DSM 30054 / NBRC 13535 / NCTC 10005 / WDCM 00083 / NCDC
RC   279-56;
RX   PubMed=20207761; DOI=10.1128/jb.00067-10;
RA   Ren Y., Ren Y., Zhou Z., Guo X., Li Y., Feng L., Wang L.;
RT   "Complete genome sequence of Enterobacter cloacae subsp. cloacae type
RT   strain ATCC 13047.";
RL   J. Bacteriol. 192:2463-2464(2010).
RN   [2]
RP   FUNCTION.
RC   STRAIN=ATCC 13047 / DSM 30054 / NBRC 13535 / NCTC 10005 / WDCM 00083 / NCDC
RC   279-56;
RX   PubMed=24889811; DOI=10.1111/mmi.12658;
RA   Beck C.M., Diner E.J., Kim J.J., Low D.A., Hayes C.S.;
RT   "The F pilus mediates a novel pathway of CDI toxin import.";
RL   Mol. Microbiol. 93:276-290(2014).
RN   [3]
RP   X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) IN COMPLEX WITH CDIA-CT, SUBUNIT,
RP   AND INDUCTION.
RC   STRAIN=ATCC 13047 / DSM 30054 / NBRC 13535 / NCTC 10005 / WDCM 00083 / NCDC
RC   279-56;
RX   PubMed=24657090; DOI=10.1016/j.str.2014.02.012;
RA   Beck C.M., Morse R.P., Cunningham D.A., Iniguez A., Low D.A.,
RA   Goulding C.W., Hayes C.S.;
RT   "CdiA from Enterobacter cloacae delivers a toxic ribosomal RNase into
RT   target bacteria.";
RL   Structure 22:707-718(2014).
CC   -!- FUNCTION: Immunity protein component of a toxin-immunity protein
CC       module, which functions as a cellular contact-dependent growth
CC       inhibition (CDI) system. CDI modules allow bacteria to communicate with
CC       and inhibit the growth of closely related neighboring bacteria in a
CC       contact-dependent fashion. Protects cells against the 16S rRNase
CC       activity of CdiA-CT, its cognate toxin protein, but not against the
CC       toxic effects of a similar rRNase, non-cognate CdiA-CT from
CC       E.chrysanthemi strain EC16. {ECO:0000269|PubMed:24657090,
CC       ECO:0000269|PubMed:24889811}.
CC   -!- SUBUNIT: Interacts with cognate toxin fragment CdiA-CT.
CC       {ECO:0000269|PubMed:24657090}.
CC   -!- INDUCTION: Not expressed under laboratory conditions.
CC       {ECO:0000269|PubMed:24657090}.
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DR   EMBL; CP001918; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; WP_044157619.1; NC_014121.1.
DR   PDB; 4NTQ; X-ray; 2.40 A; B=1-145.
DR   PDBsum; 4NTQ; -.
DR   AlphaFoldDB; A0A023GPJ0; -.
DR   SMR; A0A023GPJ0; -.
DR   Proteomes; UP000002363; Chromosome.
DR   InterPro; IPR040509; CdiI_C.
DR   Pfam; PF18228; CdiI_N; 1.
PE   1: Evidence at protein level;
KW   3D-structure.
FT   CHAIN           1..145
FT                   /note="Immunity protein CdiI"
FT                   /id="PRO_0000432080"
FT   STRAND          2..6
FT                   /evidence="ECO:0007829|PDB:4NTQ"
FT   STRAND          11..13
FT                   /evidence="ECO:0007829|PDB:4NTQ"
FT   STRAND          16..25
FT                   /evidence="ECO:0007829|PDB:4NTQ"
FT   STRAND          28..35
FT                   /evidence="ECO:0007829|PDB:4NTQ"
FT   HELIX           41..58
FT                   /evidence="ECO:0007829|PDB:4NTQ"
FT   STRAND          60..66
FT                   /evidence="ECO:0007829|PDB:4NTQ"
FT   HELIX           71..73
FT                   /evidence="ECO:0007829|PDB:4NTQ"
FT   STRAND          74..85
FT                   /evidence="ECO:0007829|PDB:4NTQ"
FT   STRAND          88..97
FT                   /evidence="ECO:0007829|PDB:4NTQ"
FT   TURN            99..101
FT                   /evidence="ECO:0007829|PDB:4NTQ"
FT   HELIX           106..112
FT                   /evidence="ECO:0007829|PDB:4NTQ"
FT   STRAND          129..132
FT                   /evidence="ECO:0007829|PDB:4NTQ"
FT   HELIX           133..144
FT                   /evidence="ECO:0007829|PDB:4NTQ"
SQ   SEQUENCE   145 AA;  16867 MW;  960FD3C16E72F45E CRC64;
     MFGIFSKGEP VSMEGELVQP SSIVINDYEE ELHLPLSYWD IKDYKNSWLK SLGEGLSNKT
     HSALAVSMYE PEKTNFIFTW VLYFEDEKVY VQNNVIFLEE CHGFSPENIN KFIESRTTHD
     GDGMKISEWH TDLNSVLDFY HSLNN