ID   CDII_YERPE              Reviewed;          77 AA.
AC   Q74RU7;
DT   04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Immunity protein CdiI {ECO:0000303|PubMed:21085179};
GN   Name=cdiI; OrderedLocusNames=YPO0600, YP_2920; ORFNames=DJ56_3415;
OS   Yersinia pestis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Colorado 92;
RA   Bishop-Lilly K.A., Broomall S.M., Chain P.S., Chertkov O., Coyne S.R.,
RA   Daligault H.E., Davenport K.W., Erkkila T., Frey K.G., Gibbons H.S., Gu W.,
RA   Jaissle J., Johnson S.L., Koroleva G.I., Ladner J.T., Lo C.-C.,
RA   Minogue T.D., Munk C., Palacios G.F., Redden C.L., Rosenzweig C.N.,
RA   Scholz M.B., Teshima H., Xu Y.;
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   FUNCTION, AND STRAIN SPECIFICITY.
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=21085179; DOI=10.1038/nature09490;
RA   Aoki S.K., Diner E.J., de Roodenbeke C.T., Burgess B.R., Poole S.J.,
RA   Braaten B.A., Jones A.M., Webb J.S., Hayes C.S., Cotter P.A., Low D.A.;
RT   "A widespread family of polymorphic contact-dependent toxin delivery
RT   systems in bacteria.";
RL   Nature 468:439-442(2010).
CC   -!- FUNCTION: Immunity protein component of a toxin-immunity protein
CC       module, which functions as a cellular contact-dependent growth
CC       inhibition (CDI) system. CDI modules allow bacteria to communicate with
CC       and inhibit the growth of closely related neighboring bacteria in a
CC       contact-dependent fashion. Protects cells against the CDI activity of
CC       CdiA, its cognate toxin protein, but not against non-cognate CdiA from
CC       E.coli strains 563, EC93 or D.dadantii strain 3937.
CC       {ECO:0000269|PubMed:21085179}.
CC   -!- SUBUNIT: Probably interacts with cognate toxin CdiA.
CC       {ECO:0000305|PubMed:21085179}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
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DR   EMBL; AE017042; AAS63101.1; -; Genomic_DNA.
DR   EMBL; AL590842; CAL19280.1; -; Genomic_DNA.
DR   EMBL; JPMB01000007; KGA55204.1; -; Genomic_DNA.
DR   PIR; AF0074; AF0074.
DR   RefSeq; WP_002214946.1; NZ_WUCM01000136.1.
DR   RefSeq; YP_002345672.1; NC_003143.1.
DR   AlphaFoldDB; Q74RU7; -.
DR   SMR; Q74RU7; -.
DR   STRING; 214092.YPO0600; -.
DR   PaxDb; Q74RU7; -.
DR   EnsemblBacteria; AAS63101; AAS63101; YP_2920.
DR   GeneID; 57974017; -.
DR   KEGG; ype:YPO0600; -.
DR   KEGG; ypm:YP_2920; -.
DR   PATRIC; fig|214092.21.peg.856; -.
DR   eggNOG; ENOG502ZDHK; Bacteria.
DR   HOGENOM; CLU_198306_0_0_6; -.
DR   Proteomes; UP000000815; Chromosome.
DR   Proteomes; UP000001019; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..77
FT                   /note="Immunity protein CdiI"
FT                   /id="PRO_0000432081"
FT   TRANSMEM        8..28
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        54..74
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   77 AA;  8719 MW;  F8C710F09E23EFC4 CRC64;
     MKNLLYVVLL MAVCILGLLI VGTIFYLFLE VFMYFYVNAP ISLESFQFTR LLKMSIYGGG
     ILGLGIGLLR IFKIKGF