ID   CDII_YERPY              Reviewed;         177 AA.
AC   A0A0R4I987; A0A0H3B164;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   08-MAY-2019, sequence version 2.
DT   25-MAY-2022, entry version 20.
DE   RecName: Full=Immunity protein CdiI-YPIII {ECO:0000303|PubMed:26449640};
DE            Short=CdiI-YPIII;
GN   Name=cdiI {ECO:0000303|PubMed:26449640}; OrderedLocusNames=YPK_0576;
OS   Yersinia pseudotuberculosis serotype O:3 (strain YPIII).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=502800;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YPIII;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C.,
RA   Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Challacombe J.F., Green L., Lindler L.E., Nikolich M.P., Richardson P.;
RT   "Complete sequence of Yersinia pseudotuberculosis YPIII.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0007744|PDB:4ZQU}
RP   X-RAY CRYSTALLOGRAPHY (2.09 ANGSTROMS) IN COMPLEX WITH CDIA, FUNCTION, AND
RP   SUBUNIT.
RC   STRAIN=YPIII;
RX   PubMed=26449640; DOI=10.1016/j.jmb.2015.09.020;
RA   Morse R.P., Willett J.L., Johnson P.M., Zheng J., Credali A., Iniguez A.,
RA   Nowick J.S., Hayes C.S., Goulding C.W.;
RT   "Diversification of beta-augmentation interactions between CDI
RT   toxin/immunity proteins.";
RL   J. Mol. Biol. 427:3766-3784(2015).
CC   -!- FUNCTION: Immunity protein component of a toxin-immunity protein
CC       module, which functions as a cellular contact-dependent growth
CC       inhibition (CDI) system. CDI modules allow bacteria to communicate with
CC       and inhibit the growth of closely related neighboring bacteria in a
CC       contact-dependent fashion. Neutralizes the toxic activity of cognate
CC       toxin CdiA-YPIII (residues 954-1077). Does not inhibit toxic activity
CC       of CdiA from other toxin-immunity modules.
CC       {ECO:0000269|PubMed:26449640}.
CC   -!- SUBUNIT: Interacts with the C-terminal DNase fragment (residues 954-
CC       1077) of cognate toxin CdiA-YPIII. {ECO:0000269|PubMed:26449640}.
CC   -!- MISCELLANEOUS: Encoded in a defective cdi locus that has been
CC       inactivated by gene rearragements and deletions.
CC       {ECO:0000305|PubMed:26449640}.
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DR   EMBL; CP000950; ACA66879.1; -; Genomic_DNA.
DR   RefSeq; WP_012303509.1; NZ_CP009792.1.
DR   PDB; 4ZQU; X-ray; 2.09 A; B=1-177.
DR   PDBsum; 4ZQU; -.
DR   AlphaFoldDB; A0A0R4I987; -.
DR   SMR; A0A0R4I987; -.
DR   EnsemblBacteria; ACA66879; ACA66879; YPK_0576.
DR   KEGG; ypy:YPK_0576; -.
DR   PATRIC; fig|502800.11.peg.1189; -.
DR   OMA; MACCWIT; -.
DR   CDD; cd13445; CDI_inhibitor_EC869_like; 1.
DR   Gene3D; 3.40.1590.10; -; 1.
DR   InterPro; IPR009888; CdiI_Proteobact.
DR   InterPro; IPR037891; Cdil-like_sf.
DR   Pfam; PF07262; CdiI; 1.
DR   SUPFAM; SSF160207; SSF160207; 1.
PE   1: Evidence at protein level;
KW   3D-structure.
FT   CHAIN           1..177
FT                   /note="Immunity protein CdiI-YPIII"
FT                   /id="PRO_0000446874"
FT   STRAND          8..14
FT                   /evidence="ECO:0007829|PDB:4ZQU"
FT   STRAND          19..32
FT                   /evidence="ECO:0007829|PDB:4ZQU"
FT   STRAND          38..41
FT                   /evidence="ECO:0007829|PDB:4ZQU"
FT   HELIX           47..59
FT                   /evidence="ECO:0007829|PDB:4ZQU"
FT   STRAND          63..67
FT                   /evidence="ECO:0007829|PDB:4ZQU"
FT   STRAND          70..72
FT                   /evidence="ECO:0007829|PDB:4ZQU"
FT   HELIX           82..85
FT                   /evidence="ECO:0007829|PDB:4ZQU"
FT   HELIX           87..105
FT                   /evidence="ECO:0007829|PDB:4ZQU"
FT   HELIX           110..115
FT                   /evidence="ECO:0007829|PDB:4ZQU"
FT   STRAND          118..124
FT                   /evidence="ECO:0007829|PDB:4ZQU"
FT   STRAND          129..133
FT                   /evidence="ECO:0007829|PDB:4ZQU"
FT   STRAND          135..138
FT                   /evidence="ECO:0007829|PDB:4ZQU"
FT   STRAND          141..143
FT                   /evidence="ECO:0007829|PDB:4ZQU"
FT   STRAND          146..149
FT                   /evidence="ECO:0007829|PDB:4ZQU"
FT   STRAND          153..155
FT                   /evidence="ECO:0007829|PDB:4ZQU"
FT   HELIX           161..172
FT                   /evidence="ECO:0007829|PDB:4ZQU"
SQ   SEQUENCE   177 AA;  19925 MW;  5FA5F4BD40CE1311 CRC64;
     MNDIVKSAWA SVKMNTDFIC VDTYSGYRSN QLDPLGVQHL SSPDVSDLDL GEMVKDALSH
     SRFVLPAPRT DIWIHPEVTF DLDLYDSRRT VERYDEWVKK LMVHYGYKTK RALFKDMKSC
     DICCNHDAIT ISPTRHEKLE VWGGTGLKGS DNVILSVDSS PTEIGAGLRL ALSRCKG