CDIN1_MOUSE
ID CDIN1_MOUSE Reviewed; 281 AA.
AC Q3U4G0; Q80WT3; Q8C1X6;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 2.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=CDAN1-interacting nuclease 1;
GN Name=Cdin1 {ECO:0000312|MGI:MGI:3026886};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=NOD;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Plays a role in erythroid cell differentiation.
CC {ECO:0000250|UniProtKB:Q9Y2V0}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y2V0}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q9Y2V0}. Note=Mainly nuclear.
CC {ECO:0000250|UniProtKB:Q9Y2V0}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3U4G0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3U4G0-2; Sequence=VSP_022272;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE32471.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK090080; BAC41083.1; -; mRNA.
DR EMBL; AK154260; BAE32471.1; ALT_FRAME; mRNA.
DR EMBL; BC052040; AAH52040.1; -; mRNA.
DR CCDS; CCDS50663.1; -. [Q3U4G0-1]
DR RefSeq; NP_001139370.1; NM_001145898.1.
DR RefSeq; NP_997147.3; NM_207264.4. [Q3U4G0-1]
DR AlphaFoldDB; Q3U4G0; -.
DR SMR; Q3U4G0; -.
DR BioGRID; 239939; 2.
DR IntAct; Q3U4G0; 1.
DR MINT; Q3U4G0; -.
DR STRING; 10090.ENSMUSP00000106543; -.
DR PhosphoSitePlus; Q3U4G0; -.
DR EPD; Q3U4G0; -.
DR MaxQB; Q3U4G0; -.
DR PaxDb; Q3U4G0; -.
DR PRIDE; Q3U4G0; -.
DR Antibodypedia; 53071; 129 antibodies from 15 providers.
DR DNASU; 399568; -.
DR Ensembl; ENSMUST00000110918; ENSMUSP00000106543; ENSMUSG00000040282. [Q3U4G0-1]
DR GeneID; 399568; -.
DR KEGG; mmu:399568; -.
DR UCSC; uc008lqr.2; mouse. [Q3U4G0-1]
DR CTD; 84529; -.
DR MGI; MGI:3026886; Cdin1.
DR VEuPathDB; HostDB:ENSMUSG00000040282; -.
DR eggNOG; ENOG502R9SY; Eukaryota.
DR GeneTree; ENSGT00390000018465; -.
DR HOGENOM; CLU_076808_0_1_1; -.
DR InParanoid; Q3U4G0; -.
DR OrthoDB; 1476922at2759; -.
DR PhylomeDB; Q3U4G0; -.
DR TreeFam; TF324079; -.
DR BioGRID-ORCS; 399568; 26 hits in 76 CRISPR screens.
DR PRO; PR:Q3U4G0; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q3U4G0; protein.
DR Bgee; ENSMUSG00000040282; Expressed in optic fissure and 225 other tissues.
DR ExpressionAtlas; Q3U4G0; baseline and differential.
DR Genevisible; Q3U4G0; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.
DR InterPro; IPR029404; CDIN1.
DR PANTHER; PTHR31661; PTHR31661; 1.
DR Pfam; PF14811; TPD; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Nucleus; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..281
FT /note="CDAN1-interacting nuclease 1"
FT /id="PRO_0000271045"
FT MOD_RES 114
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y2V0"
FT VAR_SEQ 1..98
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_022272"
FT CONFLICT 146
FT /note="N -> D (in Ref. 1; BAC41083)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 281 AA; 32113 MW; 36231C5421582333 CRC64;
MILTKAQYEE IAQCLVSVPP TRQSLRKLKQ RFPSQSQATL LSIFSQEYQK HIKRTHAKHH
TPEAIESYYQ RYLNGVGKNG AAPVLLELAN EVDYAPSLMA RIILERFLQG HEQTPPSKSV
INSMLRDPSQ IPDGVLANQV YQCIVNDCCY GPLVDCIKHA IGYEHEVLLR DLLLKKNLSF
LDEDQLRAKG YDKTPDFILQ VPVAVEGHII HWIESKASFG DECSHHAYLH GQFWSYWNRF
GPGLVIYWYG FIQELDCNRE RGILLKASFP TDIVTLCHST A
