ID   CDKA1_MESAU             Reviewed;         114 AA.
AC   P49119;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Cyclin-dependent kinase 2-associated protein 1;
DE            Short=CDK2-associated protein 1;
DE   AltName: Full=Deleted in oral cancer 1;
DE            Short=DOC-1;
DE   AltName: Full=Putative oral cancer suppressor;
GN   Name=CDK2AP1; Synonyms=CDKAP1, DOC1;
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7557027; DOI=10.1096/fasebj.9.13.7557027;
RA   Todd R., McBride J., Tsuji T., Donoff R.B., Nagai M., Chou M.Y., Chiang T.,
RA   Wong D.T.W.;
RT   "Deleted in oral cancer-1 (doc-1), a novel oral tumor suppressor gene.";
RL   FASEB J. 9:1362-1370(1995).
CC   -!- FUNCTION: specific inhibitor of the cell-cycle kinase CDK2.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Interacts with monomeric unphosphorylated CDK2.
CC       Interacts with CDK2AP2. {ECO:0000250|UniProtKB:O14519,
CC       ECO:0000250|UniProtKB:O35207}.
CC   -!- TISSUE SPECIFICITY: Oral keratinocytes.
CC   -!- PTM: Phosphorylated in vitro by IKBKE at Ser-45. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CDK2AP family. {ECO:0000305}.
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DR   EMBL; U10249; AAA92557.1; -; mRNA.
DR   RefSeq; NP_001268620.1; NM_001281691.1.
DR   AlphaFoldDB; P49119; -.
DR   SMR; P49119; -.
DR   STRING; 10036.XP_005080678.1; -.
DR   GeneID; 101825251; -.
DR   CTD; 8099; -.
DR   eggNOG; KOG4713; Eukaryota.
DR   OrthoDB; 1630301at2759; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR017266; DOC_1/2.
DR   PANTHER; PTHR22607; PTHR22607; 1.
DR   Pfam; PF09806; CDK2AP; 1.
DR   PIRSF; PIRSF037709; CDK2-associated_p2; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Disulfide bond; Phosphoprotein; Reference proteome;
KW   Tumor suppressor.
FT   CHAIN           1..114
FT                   /note="Cyclin-dependent kinase 2-associated protein 1"
FT                   /id="PRO_0000089453"
FT   REGION          18..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          19..24
FT                   /note="Interaction with CDK2AP2"
FT                   /evidence="ECO:0000250|UniProtKB:O14519"
FT   COMPBIAS        19..57
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         45
FT                   /note="Phosphoserine; by IKKE"
FT                   /evidence="ECO:0000250|UniProtKB:O14519"
FT   DISULFID        104
FT                   /note="Interchain"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   114 AA;  12354 MW;  6421DD87E438F02D CRC64;
     MSYKPNLTAH MPAAALNAGS VHSPSTSMAT SSQYRQLLSD YGPPSLGYTQ GTGNSQVPQS
     KYAELLAIIE ELGKEIRPTY AGSKSAMERL KRGIIHARSL VRECLAETER NARS