ID   CDKA2_BOVIN             Reviewed;         127 AA.
AC   Q58CN7;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Cyclin-dependent kinase 2-associated protein 2;
DE            Short=CDK2-associated protein 2;
DE   AltName: Full=DOC-1-related protein;
DE            Short=DOC-1R;
GN   Name=CDK2AP2; Synonyms=DOC1R;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: Plays a role in regulating the self-renewal of embryonic stem
CC       cells (ESCs) and in maintaining cell survival during terminal
CC       differentiation of ESCs. Regulates microtubule organization of
CC       metaphase II oocytes. Inhibits cell cycle G1/S phase transition by
CC       repressing CDK2 expression and activation; represses CDK2 activation by
CC       inhibiting its interaction with cyclin E and A.
CC       {ECO:0000250|UniProtKB:O75956, ECO:0000250|UniProtKB:Q9CPY4}.
CC   -!- SUBUNIT: Interacts with MAPK1, CDK2 and CDK2AP1.
CC       {ECO:0000250|UniProtKB:O75956, ECO:0000250|UniProtKB:Q9CPY4}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9CPY4}. Nucleus
CC       {ECO:0000250|UniProtKB:Q9CPY4}. Note=Accumulates in immature oocytes in
CC       the nucleus. During the first meiotic division, accumulates in the
CC       cytoplasm and localizes in dots in the vicinity of the chromosomes in a
CC       region enriched in microtubules. {ECO:0000250|UniProtKB:Q9CPY4}.
CC   -!- PTM: Phosphorylated by MAPK1 and CDK2. {ECO:0000250|UniProtKB:Q9CPY4}.
CC   -!- SIMILARITY: Belongs to the CDK2AP family. {ECO:0000305}.
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DR   EMBL; BT021910; AAX46757.1; -; mRNA.
DR   RefSeq; NP_001030397.1; NM_001035320.1.
DR   AlphaFoldDB; Q58CN7; -.
DR   BMRB; Q58CN7; -.
DR   SMR; Q58CN7; -.
DR   STRING; 9913.ENSBTAP00000002738; -.
DR   PaxDb; Q58CN7; -.
DR   PRIDE; Q58CN7; -.
DR   Ensembl; ENSBTAT00000002738; ENSBTAP00000002738; ENSBTAG00000002121.
DR   GeneID; 517206; -.
DR   KEGG; bta:517206; -.
DR   CTD; 10263; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002121; -.
DR   VGNC; VGNC:27126; CDK2AP2.
DR   eggNOG; KOG4713; Eukaryota.
DR   GeneTree; ENSGT00940000160334; -.
DR   HOGENOM; CLU_130479_0_0_1; -.
DR   InParanoid; Q58CN7; -.
DR   OMA; GYVQTMK; -.
DR   OrthoDB; 1630301at2759; -.
DR   TreeFam; TF101037; -.
DR   Proteomes; UP000009136; Chromosome 29.
DR   Bgee; ENSBTAG00000002121; Expressed in oocyte and 106 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005874; C:microtubule; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; ISS:UniProtKB.
DR   GO; GO:0070507; P:regulation of microtubule cytoskeleton organization; ISS:UniProtKB.
DR   GO; GO:2000035; P:regulation of stem cell division; ISS:UniProtKB.
DR   InterPro; IPR017266; DOC_1/2.
DR   PANTHER; PTHR22607; PTHR22607; 1.
DR   Pfam; PF09806; CDK2AP; 1.
DR   PIRSF; PIRSF037709; CDK2-associated_p2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..127
FT                   /note="Cyclin-dependent kinase 2-associated protein 2"
FT                   /id="PRO_0000079962"
FT   REGION          1..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          65..107
FT                   /note="Interaction with CDK2"
FT                   /evidence="ECO:0000250|UniProtKB:O75956"
FT   COMPBIAS        12..28
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   127 AA;  13172 MW;  4E2FFC25A6EF07CB CRC64;
     MSYKPIAPAP SSTPGSSTPG PGTPVPTAGS VPSPSGSVPG AAGPFRPLFN DFGPPSMGYV
     QAMKPPGAQG SQSTYTDLLS VIEEMGKEIR PTYAGSKSAM ERLKRGIIHA RALVRECLAE
     TERNART