ID   CDKL1_DANRE             Reviewed;         350 AA.
AC   Q6AXJ9;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Cyclin-dependent kinase-like 1 {ECO:0000250|UniProtKB:Q00532};
DE            EC=2.7.11.22;
GN   Name=cdkl1 {ECO:0000250|UniProtKB:Q00532}; ORFNames=zgc:101002;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.22;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- DOMAIN: The [NKR]KIAxRE motif seems to be a cyclin-binding region.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr
CC       protein kinase family. CDC2/CDKX subfamily. {ECO:0000305}.
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DR   EMBL; BC079506; AAH79506.1; -; mRNA.
DR   RefSeq; NP_001003773.1; NM_001003773.1.
DR   AlphaFoldDB; Q6AXJ9; -.
DR   SMR; Q6AXJ9; -.
DR   STRING; 7955.ENSDARP00000044356; -.
DR   PaxDb; Q6AXJ9; -.
DR   GeneID; 445316; -.
DR   KEGG; dre:445316; -.
DR   CTD; 8814; -.
DR   ZFIN; ZDB-GENE-040808-34; cdkl1.
DR   eggNOG; KOG0593; Eukaryota.
DR   InParanoid; Q6AXJ9; -.
DR   OrthoDB; 398098at2759; -.
DR   PhylomeDB; Q6AXJ9; -.
DR   PRO; PR:Q6AXJ9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; ISS:ZFIN.
DR   GO; GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR   GO; GO:0004672; F:protein kinase activity; IDA:ZFIN.
DR   GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; ISS:ZFIN.
DR   GO; GO:0006468; P:protein phosphorylation; IDA:ZFIN.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cytoplasm; Kinase; Nucleotide-binding; Nucleus;
KW   Reference proteome; Serine/threonine-protein kinase; Transferase.
FT   CHAIN           1..350
FT                   /note="Cyclin-dependent kinase-like 1"
FT                   /id="PRO_0000085813"
FT   DOMAIN          4..287
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   REGION          293..318
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           45..51
FT                   /note="[NKR]KIAxRE"
FT   ACT_SITE        126
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT                   ECO:0000255|PROSITE-ProRule:PRU10027"
FT   BINDING         10..18
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   BINDING         33
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ   SEQUENCE   350 AA;  40810 MW;  9B04440EE0E38BE1 CRC64;
     MEKYEKISKI GEGSYGVVFK CRNKDTGQIV AIKKFVESED DPIIKKIALR EIRMLKQLKH
     PNLVNLMEVF RRKRKLHLVF EYCDHTVLNE LDRYPRGVPE HMVKSIIWQT LQAVNFCHKQ
     NCIHRDVKPE NILITKHQVI KLCDFGFARI LTGPCDYYTD CVATRWYRAP ELLVGDTQYG
     PPVDVWAVGC VFAELLSGAP LWPGKSDVDQ LYLIRKTLGE LIPRHQQVFS TNQFFSGVCV
     PEPQEMEPLE LKYPNLSYQA LSLMKGCLRM DPAERLSCEQ LLEQPYFDSL REESESVTRE
     LDRKKRTRQP RKHLPPGYLP QLASSTVFPA VENRRNYNNL RKFNYHLPNI