ID   CDN2B_BOVIN             Reviewed;         131 AA.
AC   Q2KJD8;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Cyclin-dependent kinase 4 inhibitor B;
DE   AltName: Full=p14-INK4b;
GN   Name=CDKN2B;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Interacts strongly with CDK4 and CDK6. Potent inhibitor.
CC       Potential effector of TGF-beta induced cell cycle arrest (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of CDKN2B with CDK4 or CDK6. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CDKN2 cyclin-dependent kinase inhibitor
CC       family. {ECO:0000305}.
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DR   EMBL; BC105392; AAI05393.1; -; mRNA.
DR   RefSeq; NP_001069362.1; NM_001075894.1.
DR   AlphaFoldDB; Q2KJD8; -.
DR   SMR; Q2KJD8; -.
DR   STRING; 9913.ENSBTAP00000002652; -.
DR   PaxDb; Q2KJD8; -.
DR   GeneID; 527124; -.
DR   KEGG; bta:527124; -.
DR   CTD; 1030; -.
DR   eggNOG; KOG0504; Eukaryota.
DR   InParanoid; Q2KJD8; -.
DR   OrthoDB; 1435166at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; ISS:UniProtKB.
DR   GO; GO:0019901; F:protein kinase binding; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0031668; P:cellular response to extracellular stimulus; ISS:UniProtKB.
DR   GO; GO:0031670; P:cellular response to nutrient; ISS:UniProtKB.
DR   GO; GO:0030219; P:megakaryocyte differentiation; ISS:UniProtKB.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; ISS:UniProtKB.
DR   GO; GO:0050680; P:negative regulation of epithelial cell proliferation; ISS:UniProtKB.
DR   GO; GO:0042326; P:negative regulation of phosphorylation; ISS:UniProtKB.
DR   GO; GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; ISS:UniProtKB.
DR   GO; GO:0070316; P:regulation of G0 to G1 transition; ISS:UniProtKB.
DR   GO; GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IBA:GO_Central.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   2: Evidence at transcript level;
KW   ANK repeat; Cell cycle; Reference proteome; Repeat; Tumor suppressor.
FT   CHAIN           1..131
FT                   /note="Cyclin-dependent kinase 4 inhibitor B"
FT                   /id="PRO_0000310856"
FT   REPEAT          6..35
FT                   /note="ANK 1"
FT   REPEAT          39..67
FT                   /note="ANK 2"
FT   REPEAT          72..101
FT                   /note="ANK 3"
FT   REPEAT          105..131
FT                   /note="ANK 4"
SQ   SEQUENCE   131 AA;  14028 MW;  A47AEEE66E90BAF7 CRC64;
     MLSGGGGDAD LANAAARGQV EAVRQLLEAG VDPNRLNRFG RRPIQVMMMG SARVAELLLL
     HGADPNCADP ATLTRPVHDA AREGFLDTLV ALHRAGGRLD VRDAWGRLPV DLAEERGHRD
     VARYLRATAG D