CDN2B_RAT
ID CDN2B_RAT Reviewed; 130 AA.
AC P55272;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Cyclin-dependent kinase 4 inhibitor B;
DE AltName: Full=p14-INK4b;
DE AltName: Full=p15-INK4b;
GN Name=Cdkn2b; Synonyms=Ink4;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7546221; DOI=10.1002/mc.2940140106;
RA Hino O., Kobayashi E., Hirayama Y., Kobayashi T., Kubo Y., Tsuchiya H.,
RA Kikuchi Y., Mitani H.;
RT "Molecular genetic basis of renal carcinogenesis in the Eker rat model of
RT tuberous sclerosis (Tsc2).";
RL Mol. Carcinog. 14:23-27(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ACI/SegHsd, and COP; TISSUE=Lung;
RA Buckles L.K., Shull J.D.;
RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 46-86.
RX PubMed=7712460;
RA Knapek D.F., Serrano M., Beach D., Trono D., Walker C.L.;
RT "Association of rat p15INK4B/p16INK4 deletions with monosomy 5 in kidney
RT epithelial cell lines but not primary renal tumors.";
RL Cancer Res. 55:1607-1612(1995).
CC -!- FUNCTION: Interacts strongly with CDK4 and CDK6. Potent inhibitor.
CC Potential effector of TGF-beta induced cell cycle arrest (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heterodimer of CDKN2B with CDK4 or CDK6.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative initiation; Named isoforms=2;
CC Name=Long;
CC IsoId=P55272-1; Sequence=Displayed;
CC Name=Short;
CC IsoId=P55272-2; Sequence=VSP_018702;
CC -!- TISSUE SPECIFICITY: Expression abundant in lung, less abundant in
CC testis, barely detectable in liver, and not detectable in neonatal
CC kidney, adult kidney, brain, heart, or spleen.
CC -!- SIMILARITY: Belongs to the CDKN2 cyclin-dependent kinase inhibitor
CC family. {ECO:0000305}.
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DR EMBL; S79760; AAB35360.1; -; mRNA.
DR EMBL; AF474978; AAL76340.1; -; mRNA.
DR EMBL; AF474979; AAL76341.1; -; mRNA.
DR EMBL; S77734; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_570825.1; NM_130812.3. [P55272-1]
DR AlphaFoldDB; P55272; -.
DR BMRB; P55272; -.
DR SMR; P55272; -.
DR STRING; 10116.ENSRNOP00000008898; -.
DR PaxDb; P55272; -.
DR DNASU; 25164; -.
DR Ensembl; ENSRNOT00000100738; ENSRNOP00000089509; ENSRNOG00000006735. [P55272-1]
DR GeneID; 25164; -.
DR KEGG; rno:25164; -.
DR UCSC; RGD:2324; rat. [P55272-1]
DR CTD; 1030; -.
DR RGD; 2324; Cdkn2b.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000162423; -.
DR InParanoid; P55272; -.
DR OrthoDB; 1435166at2759; -.
DR PhylomeDB; P55272; -.
DR TreeFam; TF352389; -.
DR Reactome; R-RNO-2559580; Oxidative Stress Induced Senescence.
DR Reactome; R-RNO-2559582; Senescence-Associated Secretory Phenotype (SASP).
DR Reactome; R-RNO-2559585; Oncogene Induced Senescence.
DR Reactome; R-RNO-69231; Cyclin D associated events in G1.
DR PRO; PR:P55272; -.
DR Proteomes; UP000002494; Chromosome 5.
DR Genevisible; P55272; RN.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005634; C:nucleus; IDA:RGD.
DR GO; GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; ISO:RGD.
DR GO; GO:0019901; F:protein kinase binding; ISO:RGD.
DR GO; GO:0007568; P:aging; IEP:RGD.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0031668; P:cellular response to extracellular stimulus; ISO:RGD.
DR GO; GO:0031670; P:cellular response to nutrient; ISO:RGD.
DR GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEP:RGD.
DR GO; GO:0090398; P:cellular senescence; ISO:RGD.
DR GO; GO:0001889; P:liver development; IEP:RGD.
DR GO; GO:0030219; P:megakaryocyte differentiation; ISO:RGD.
DR GO; GO:1902807; P:negative regulation of cell cycle G1/S phase transition; IMP:RGD.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IMP:RGD.
DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; ISO:RGD.
DR GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; ISO:RGD.
DR GO; GO:0060253; P:negative regulation of glial cell proliferation; IMP:RGD.
DR GO; GO:0042326; P:negative regulation of phosphorylation; ISO:RGD.
DR GO; GO:0030858; P:positive regulation of epithelial cell differentiation; IEP:RGD.
DR GO; GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; ISO:RGD.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; ISO:RGD.
DR GO; GO:0070316; P:regulation of G0 to G1 transition; ISO:RGD.
DR GO; GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0034097; P:response to cytokine; IEP:RGD.
DR GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
DR GO; GO:0048536; P:spleen development; ISO:RGD.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF12796; Ank_2; 1.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 2: Evidence at transcript level;
KW Alternative initiation; ANK repeat; Cell cycle; Phosphoprotein;
KW Reference proteome; Repeat; Tumor suppressor.
FT CHAIN 1..130
FT /note="Cyclin-dependent kinase 4 inhibitor B"
FT /id="PRO_0000004808"
FT REPEAT 5..34
FT /note="ANK 1"
FT REPEAT 38..66
FT /note="ANK 2"
FT REPEAT 71..100
FT /note="ANK 3"
FT REPEAT 104..130
FT /note="ANK 4"
FT MOD_RES 12
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P55271"
FT VAR_SEQ 1..45
FT /note="Missing (in isoform Short)"
FT /evidence="ECO:0000305"
FT /id="VSP_018702"
SQ SEQUENCE 130 AA; 13749 MW; AC45B21FA69FAD92 CRC64;
MLGGGSDAGL ATAAARGQVE TVRQLLEAGA DPNAVNRFGR RPIQVMMMGS AQVAELLLLH
GAEPNCADPA TLTRPVHDAA REGFLDTLMV LHKAGARLDV CDAWGRLPVD LAEEQGHRDI
ARYLHAATGD
