CDN2C_MOUSE
ID CDN2C_MOUSE Reviewed; 168 AA.
AC Q60772;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Cyclin-dependent kinase 4 inhibitor C;
DE AltName: Full=Cyclin-dependent kinase 6 inhibitor;
DE AltName: Full=p18-INK4c;
DE AltName: Full=p18-INK6;
GN Name=Cdkn2c;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/Kaplan;
RX PubMed=7739547; DOI=10.1128/mcb.15.5.2672;
RA Hirai H., Roussel M.F., Kato J.-Y., Ashmun R.A., Sherr C.J.;
RT "Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-
RT dependent kinases CDK4 and CDK6.";
RL Mol. Cell. Biol. 15:2672-2681(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N-3; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Interacts strongly with CDK6, weakly with CDK4. Inhibits cell
CC growth and proliferation with a correlated dependence on endogenous
CC retinoblastoma protein RB.
CC -!- SUBUNIT: Heterodimer of p18 with CDK6. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CDKN2 cyclin-dependent kinase inhibitor
CC family. {ECO:0000305}.
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DR EMBL; U19596; AAC52193.1; -; mRNA.
DR EMBL; BC027026; AAH27026.1; -; mRNA.
DR CCDS; CCDS18467.1; -.
DR PIR; B57379; B57379.
DR RefSeq; NP_001288297.1; NM_001301368.1.
DR RefSeq; NP_031697.1; NM_007671.3.
DR AlphaFoldDB; Q60772; -.
DR SMR; Q60772; -.
DR BioGRID; 198656; 2.
DR CORUM; Q60772; -.
DR DIP; DIP-60250N; -.
DR IntAct; Q60772; 1.
DR STRING; 10090.ENSMUSP00000095534; -.
DR iPTMnet; Q60772; -.
DR PhosphoSitePlus; Q60772; -.
DR EPD; Q60772; -.
DR MaxQB; Q60772; -.
DR PaxDb; Q60772; -.
DR PeptideAtlas; Q60772; -.
DR PRIDE; Q60772; -.
DR ProteomicsDB; 281522; -.
DR Antibodypedia; 3941; 567 antibodies from 36 providers.
DR DNASU; 12580; -.
DR Ensembl; ENSMUST00000063531; ENSMUSP00000070313; ENSMUSG00000028551.
DR Ensembl; ENSMUST00000097921; ENSMUSP00000095534; ENSMUSG00000028551.
DR GeneID; 12580; -.
DR KEGG; mmu:12580; -.
DR UCSC; uc008ucr.1; mouse.
DR CTD; 1031; -.
DR MGI; MGI:105388; Cdkn2c.
DR VEuPathDB; HostDB:ENSMUSG00000028551; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000160194; -.
DR HOGENOM; CLU_000134_37_0_1; -.
DR InParanoid; Q60772; -.
DR OMA; MAEPLGN; -.
DR OrthoDB; 1453965at2759; -.
DR PhylomeDB; Q60772; -.
DR TreeFam; TF333311; -.
DR BioGRID-ORCS; 12580; 2 hits in 76 CRISPR screens.
DR PRO; PR:Q60772; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q60772; protein.
DR Bgee; ENSMUSG00000028551; Expressed in spermatocyte and 204 other tissues.
DR Genevisible; Q60772; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; IDA:MGI.
DR GO; GO:0019901; F:protein kinase binding; IPI:MGI.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0008283; P:cell population proliferation; IGI:MGI.
DR GO; GO:0030308; P:negative regulation of cell growth; ISO:MGI.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:MGI.
DR GO; GO:0045736; P:negative regulation of cyclin-dependent protein serine/threonine kinase activity; IDA:MGI.
DR GO; GO:0042326; P:negative regulation of phosphorylation; ISO:MGI.
DR GO; GO:2000647; P:negative regulation of stem cell proliferation; IGI:MGI.
DR GO; GO:0048709; P:oligodendrocyte differentiation; IEA:Ensembl.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; ISO:MGI.
DR GO; GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; ISO:MGI.
DR GO; GO:0072089; P:stem cell proliferation; IGI:MGI.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13637; Ank_4; 1.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 1: Evidence at protein level;
KW ANK repeat; Cell cycle; Reference proteome; Repeat.
FT CHAIN 1..168
FT /note="Cyclin-dependent kinase 4 inhibitor C"
FT /id="PRO_0000144187"
FT REPEAT 4..33
FT /note="ANK 1"
FT REPEAT 37..65
FT /note="ANK 2"
FT REPEAT 69..98
FT /note="ANK 3"
FT REPEAT 102..132
FT /note="ANK 4"
FT REPEAT 136..165
FT /note="ANK 5"
SQ SEQUENCE 168 AA; 18066 MW; BC88D5489307E128 CRC64;
MAEPWGNELA SAAARGDLEQ LTSLLQNNVN VNAQNGFGRT ALQVMKLGNP EIARRLLLRG
ANPNLKDGTG FAVIHDAARA GFLDTVQALL EFQADVNIED NEGNLPLHLA AKEGHLPVVE
FLMKHTACNV GHRNHKGDTA FDLARFYGRN EVISLMEANG VGGATSLQ
