ID   CDN2D_BOVIN             Reviewed;         166 AA.
AC   Q29RV0;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Cyclin-dependent kinase 4 inhibitor D;
DE   AltName: Full=p19-INK4d;
GN   Name=CDKN2D;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Interacts strongly with CDK4 and CDK6 and inhibits them.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CDK6. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CDKN2 cyclin-dependent kinase inhibitor
CC       family. {ECO:0000305}.
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DR   EMBL; BC114005; AAI14006.1; -; mRNA.
DR   RefSeq; NP_001039515.1; NM_001046050.1.
DR   RefSeq; XP_010805120.1; XM_010806818.1.
DR   AlphaFoldDB; Q29RV0; -.
DR   SMR; Q29RV0; -.
DR   STRING; 9913.ENSBTAP00000014209; -.
DR   PaxDb; Q29RV0; -.
DR   PRIDE; Q29RV0; -.
DR   Ensembl; ENSBTAT00000014209; ENSBTAP00000014209; ENSBTAG00000010731.
DR   Ensembl; ENSBTAT00000078336; ENSBTAP00000058401; ENSBTAG00000010731.
DR   GeneID; 510244; -.
DR   KEGG; bta:510244; -.
DR   CTD; 1032; -.
DR   VEuPathDB; HostDB:ENSBTAG00000010731; -.
DR   VGNC; VGNC:27147; CDKN2D.
DR   eggNOG; KOG0504; Eukaryota.
DR   GeneTree; ENSGT00940000159801; -.
DR   HOGENOM; CLU_000134_37_0_1; -.
DR   InParanoid; Q29RV0; -.
DR   OMA; LHQEFVH; -.
DR   OrthoDB; 1453965at2759; -.
DR   TreeFam; TF333311; -.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000010731; Expressed in Ammon's horn and 106 other tissues.
DR   GO; GO:0097129; C:cyclin D2-CDK4 complex; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; IEA:Ensembl.
DR   GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR   GO; GO:0048102; P:autophagic cell death; IEA:Ensembl.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0000731; P:DNA synthesis involved in DNA repair; IEA:Ensembl.
DR   GO; GO:1902807; P:negative regulation of cell cycle G1/S phase transition; IEA:Ensembl.
DR   GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR   GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl.
DR   GO; GO:1902230; P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; IEA:Ensembl.
DR   GO; GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0032526; P:response to retinoic acid; IEA:Ensembl.
DR   GO; GO:0009411; P:response to UV; IEA:Ensembl.
DR   GO; GO:0033280; P:response to vitamin D; IEA:Ensembl.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF12796; Ank_2; 1.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; ANK repeat; Cell cycle; Cytoplasm; Nucleus;
KW   Reference proteome; Repeat; Tumor suppressor.
FT   CHAIN           1..166
FT                   /note="Cyclin-dependent kinase 4 inhibitor D"
FT                   /id="PRO_0000310855"
FT   REPEAT          41..69
FT                   /note="ANK 1"
FT   REPEAT          73..102
FT                   /note="ANK 2"
FT   REPEAT          106..135
FT                   /note="ANK 3"
FT   REPEAT          138..166
FT                   /note="ANK 4"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:P55273"
SQ   SEQUENCE   166 AA;  17681 MW;  A6BF4A6FF08F884D CRC64;
     MLLEEVHAGD RLSGAAARGD VQEVRRLLHS ELVHPDVLNR FGKTALQVMM FGSPTIALEL
     LKQGASPNVQ DASGTTPAHD AARTGFLDTL KVLVEHGADV NAPDGTGALP IHLAVREGHT
     SVVSFLATES DLHHRDATGL TPLELARGRG AQELMDILQR HTVAPL