CDNF_MOUSE
ID CDNF_MOUSE Reviewed; 187 AA.
AC Q8CC36;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Cerebral dopamine neurotrophic factor;
DE AltName: Full=ARMET-like protein 1;
DE AltName: Full=Conserved dopamine neurotrophic factor;
DE Flags: Precursor;
GN Name=Cdnf; Synonyms=Armetl1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Diencephalon;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=17611540; DOI=10.1038/nature05957;
RA Lindholm P., Voutilainen M.H., Lauren J., Peraenen J., Leppaenen V.-M.,
RA Andressoo J.-O., Lindahl M., Janhunen S., Kalkkinen N., Timmusk T.,
RA Tuominen R.K., Saarma M.;
RT "Novel neurotrophic factor CDNF protects and rescues midbrain dopamine
RT neurons in vivo.";
RL Nature 448:73-77(2007).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Trophic factor for dopamine neurons. Prevents the 6-
CC hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons.
CC When administered after 6-OHDA-lesioning, restores the dopaminergic
CC function and prevents the degeneration of dopaminergic neurons in
CC substantia nigra (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17611540}.
CC -!- TISSUE SPECIFICITY: Expressed at high levels in the heart, skeletal
CC muscle, testis and brain (at protein level). In the brain, detected in
CC the cerebral cortex neurons through layers II to VI. In the
CC hippocampus, detected in the CA1 to CA3 pyramidal regions and in the
CC granule and polymorph layers of dentate gyrus. Weak expression in the
CC striatum. In substantia nigra, detected in solitary cells that did not
CC express tyrosine hydroxylase, a marker for dopaminergic neurons.
CC Relatively high expression in the Purkinje cells of the cerebellum and
CC in regions of the brain stem, including the locus coeruleus.
CC {ECO:0000269|PubMed:17611540}.
CC -!- DEVELOPMENTAL STAGE: At postnatal stage P1 and P10, expressed in the
CC brain, including the hippocampus, thalamus, striatum and substantia
CC nigra. Highest levels in the hippocampus and thalamus.
CC {ECO:0000269|PubMed:17611540}.
CC -!- SIMILARITY: Belongs to the ARMET family. {ECO:0000305}.
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DR EMBL; AK034009; BAC28545.1; -; mRNA.
DR EMBL; AL732620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL929080; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC110560; AAI10561.1; -; mRNA.
DR CCDS; CCDS15654.1; -.
DR RefSeq; NP_808315.1; NM_177647.4.
DR AlphaFoldDB; Q8CC36; -.
DR SMR; Q8CC36; -.
DR STRING; 10090.ENSMUSP00000046297; -.
DR PhosphoSitePlus; Q8CC36; -.
DR jPOST; Q8CC36; -.
DR MaxQB; Q8CC36; -.
DR PaxDb; Q8CC36; -.
DR PeptideAtlas; Q8CC36; -.
DR PRIDE; Q8CC36; -.
DR ProteomicsDB; 281442; -.
DR Antibodypedia; 24933; 296 antibodies from 32 providers.
DR DNASU; 227526; -.
DR Ensembl; ENSMUST00000036350; ENSMUSP00000046297; ENSMUSG00000039496.
DR GeneID; 227526; -.
DR KEGG; mmu:227526; -.
DR UCSC; uc008iej.1; mouse.
DR CTD; 441549; -.
DR MGI; MGI:3606576; Cdnf.
DR VEuPathDB; HostDB:ENSMUSG00000039496; -.
DR eggNOG; KOG4154; Eukaryota.
DR GeneTree; ENSGT00390000007160; -.
DR HOGENOM; CLU_099080_1_0_1; -.
DR InParanoid; Q8CC36; -.
DR OMA; ARPMSVH; -.
DR OrthoDB; 1427430at2759; -.
DR PhylomeDB; Q8CC36; -.
DR TreeFam; TF314252; -.
DR BioGRID-ORCS; 227526; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q8CC36; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8CC36; protein.
DR Bgee; ENSMUSG00000039496; Expressed in quadriceps femoris and 50 other tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0071542; P:dopaminergic neuron differentiation; IBA:GO_Central.
DR GO; GO:0031175; P:neuron projection development; IBA:GO_Central.
DR Gene3D; 1.10.720.30; -; 1.
DR InterPro; IPR045333; ARMET-like.
DR InterPro; IPR019345; ARMET_C.
DR InterPro; IPR045332; ARMET_N.
DR InterPro; IPR036361; SAP_dom_sf.
DR PANTHER; PTHR12990; PTHR12990; 1.
DR Pfam; PF10208; ARMET_C; 1.
DR Pfam; PF20145; ARMET_N; 1.
DR SUPFAM; SSF68906; SSF68906; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Growth factor; Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..187
FT /note="Cerebral dopamine neurotrophic factor"
FT /id="PRO_0000281138"
FT DISULFID 37..124
FT /evidence="ECO:0000250"
FT DISULFID 40..113
FT /evidence="ECO:0000250"
FT DISULFID 71..82
FT /evidence="ECO:0000250"
SQ SEQUENCE 187 AA; 21032 MW; 24DFFE42026A7971 CRC64;
MRCISPTALV TFCAGFCISN PVLAQGLEAG VGPRADCEVC KEFLDRFYNS LLSRGIDFSA
DTIEKELLNF CSDAKGKENR LCYYLGATTD AATKILGEVT RPMSVHIPAV KICEKLKKMD
SQICELKYGK KLDLASVDLW KMRVAELKQI LQRWGEECRA CAEKSDYVNL IRELAPKYVE
IYPQTEL
