CDNF_RAT
ID CDNF_RAT Reviewed; 187 AA.
AC P0C5I0;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 1.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Cerebral dopamine neurotrophic factor;
DE AltName: Full=ARMET-like protein 1;
DE AltName: Full=Arginine-rich protein mutated in early stage tumors-like 1;
DE AltName: Full=Conserved dopamine neurotrophic factor;
DE Flags: Precursor;
GN Name=Cdnf; Synonyms=Armetl1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP FUNCTION.
RX PubMed=17611540; DOI=10.1038/nature05957;
RA Lindholm P., Voutilainen M.H., Lauren J., Peraenen J., Leppaenen V.-M.,
RA Andressoo J.-O., Lindahl M., Janhunen S., Kalkkinen N., Timmusk T.,
RA Tuominen R.K., Saarma M.;
RT "Novel neurotrophic factor CDNF protects and rescues midbrain dopamine
RT neurons in vivo.";
RL Nature 448:73-77(2007).
CC -!- FUNCTION: Trophic factor for dopamine neurons. Prevents the 6-
CC hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons.
CC When administered after 6-OHDA-lesioning, restores the dopaminergic
CC function and prevents the degeneration of dopaminergic neurons in
CC substantia nigra. {ECO:0000269|PubMed:17611540}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ARMET family. {ECO:0000305}.
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DR EMBL; AABR03104971; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03106335; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03107130; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001032632.1; NM_001037543.1.
DR AlphaFoldDB; P0C5I0; -.
DR SMR; P0C5I0; -.
DR STRING; 10116.ENSRNOP00000030751; -.
DR PaxDb; P0C5I0; -.
DR PRIDE; P0C5I0; -.
DR Ensembl; ENSRNOT00000036299; ENSRNOP00000030751; ENSRNOG00000026493.
DR GeneID; 361276; -.
DR KEGG; rno:361276; -.
DR UCSC; RGD:1307600; rat.
DR CTD; 441549; -.
DR RGD; 1307600; Cdnf.
DR eggNOG; KOG4154; Eukaryota.
DR GeneTree; ENSGT00390000007160; -.
DR HOGENOM; CLU_099080_1_0_1; -.
DR InParanoid; P0C5I0; -.
DR OMA; ARPMSVH; -.
DR OrthoDB; 1427430at2759; -.
DR PhylomeDB; P0C5I0; -.
DR TreeFam; TF314252; -.
DR PRO; PR:P0C5I0; -.
DR Proteomes; UP000002494; Chromosome 17.
DR Bgee; ENSRNOG00000026493; Expressed in skeletal muscle tissue and 4 other tissues.
DR Genevisible; P0C5I0; RN.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0071542; P:dopaminergic neuron differentiation; IBA:GO_Central.
DR GO; GO:0031175; P:neuron projection development; IBA:GO_Central.
DR Gene3D; 1.10.720.30; -; 1.
DR InterPro; IPR045333; ARMET-like.
DR InterPro; IPR019345; ARMET_C.
DR InterPro; IPR045332; ARMET_N.
DR InterPro; IPR036361; SAP_dom_sf.
DR PANTHER; PTHR12990; PTHR12990; 1.
DR Pfam; PF10208; ARMET_C; 1.
DR Pfam; PF20145; ARMET_N; 1.
DR SUPFAM; SSF68906; SSF68906; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Growth factor; Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..187
FT /note="Cerebral dopamine neurotrophic factor"
FT /id="PRO_0000306860"
FT DISULFID 37..124
FT /evidence="ECO:0000250"
FT DISULFID 40..113
FT /evidence="ECO:0000250"
FT DISULFID 71..82
FT /evidence="ECO:0000250"
SQ SEQUENCE 187 AA; 21361 MW; C04217BD6E48F8E1 CRC64;
MRCTSPAALV TFCAGLWISN HVLAQGLEAG VRSRADCEVC KEFLNRFYNS LLTRGIDFSV
DTIEEELISF CADTKGKENR LCYYLGATKD SATKILGEVT RPMSVHMPTV KICEKLKKMD
SQICELKYEK KLDLESVDLW KMRVAELKQI LHSWGEECRA CAEKHDYVNL IKELAPKYVE
TRPQTEL
