CDPF1_HUMAN
ID CDPF1_HUMAN Reviewed; 123 AA.
AC Q6NVV7; A6NCA1; A9IU12; A9IU16; Q3ZCR8;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Cysteine-rich DPF motif domain-containing protein 1;
GN Name=CDPF1; Synonyms=C22orf40;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q6NVV7; O14503: BHLHE40; NbExp=3; IntAct=EBI-2802782, EBI-711810;
CC Q6NVV7; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-2802782, EBI-744545;
CC Q6NVV7; Q02930-3: CREB5; NbExp=3; IntAct=EBI-2802782, EBI-10192698;
CC Q6NVV7; Q96D03: DDIT4L; NbExp=3; IntAct=EBI-2802782, EBI-742054;
CC Q6NVV7; O95967: EFEMP2; NbExp=3; IntAct=EBI-2802782, EBI-743414;
CC Q6NVV7; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-2802782, EBI-744099;
CC Q6NVV7; A4D161: FAM221A; NbExp=3; IntAct=EBI-2802782, EBI-11960181;
CC Q6NVV7; O43559: FRS3; NbExp=3; IntAct=EBI-2802782, EBI-725515;
CC Q6NVV7; P56524-2: HDAC4; NbExp=3; IntAct=EBI-2802782, EBI-11953488;
CC Q6NVV7; P49639: HOXA1; NbExp=3; IntAct=EBI-2802782, EBI-740785;
CC Q6NVV7; Q7L273: KCTD9; NbExp=3; IntAct=EBI-2802782, EBI-4397613;
CC Q6NVV7; Q8IVT2: MISP; NbExp=3; IntAct=EBI-2802782, EBI-2555085;
CC Q6NVV7; A2BDE7: PHLDA1; NbExp=3; IntAct=EBI-2802782, EBI-14084211;
CC Q6NVV7; Q7Z6R9: TFAP2D; NbExp=3; IntAct=EBI-2802782, EBI-11952651;
CC Q6NVV7; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-2802782, EBI-11957216;
CC Q6NVV7; Q15915: ZIC1; NbExp=3; IntAct=EBI-2802782, EBI-11963196;
CC -!- SIMILARITY: Belongs to the CDPF1 family. {ECO:0000305}.
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DR EMBL; AL078611; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471138; EAW73407.1; -; Genomic_DNA.
DR EMBL; BC045796; AAH45796.1; -; mRNA.
DR EMBL; BC067871; AAH67871.1; -; mRNA.
DR CCDS; CCDS33670.1; -.
DR RefSeq; NP_997210.3; NM_207327.4.
DR RefSeq; XP_011528267.1; XM_011529965.2.
DR AlphaFoldDB; Q6NVV7; -.
DR BioGRID; 127293; 34.
DR IntAct; Q6NVV7; 18.
DR MINT; Q6NVV7; -.
DR STRING; 9606.ENSP00000325301; -.
DR iPTMnet; Q6NVV7; -.
DR PhosphoSitePlus; Q6NVV7; -.
DR BioMuta; CDPF1; -.
DR DMDM; 74749009; -.
DR EPD; Q6NVV7; -.
DR jPOST; Q6NVV7; -.
DR MassIVE; Q6NVV7; -.
DR MaxQB; Q6NVV7; -.
DR PaxDb; Q6NVV7; -.
DR PeptideAtlas; Q6NVV7; -.
DR PRIDE; Q6NVV7; -.
DR ProteomicsDB; 66725; -.
DR Antibodypedia; 13834; 38 antibodies from 11 providers.
DR DNASU; 150383; -.
DR Ensembl; ENST00000314567.8; ENSP00000325301.3; ENSG00000205643.11.
DR GeneID; 150383; -.
DR KEGG; hsa:150383; -.
DR MANE-Select; ENST00000314567.8; ENSP00000325301.3; NM_207327.5; NP_997210.3.
DR UCSC; uc003bhe.4; human.
DR CTD; 150383; -.
DR GeneCards; CDPF1; -.
DR HGNC; HGNC:33710; CDPF1.
DR HPA; ENSG00000205643; Low tissue specificity.
DR neXtProt; NX_Q6NVV7; -.
DR OpenTargets; ENSG00000205643; -.
DR PharmGKB; PA162379006; -.
DR VEuPathDB; HostDB:ENSG00000205643; -.
DR eggNOG; KOG4543; Eukaryota.
DR GeneTree; ENSGT00390000007925; -.
DR HOGENOM; CLU_138011_0_0_1; -.
DR InParanoid; Q6NVV7; -.
DR OMA; MHELVHY; -.
DR OrthoDB; 1278628at2759; -.
DR PhylomeDB; Q6NVV7; -.
DR TreeFam; TF313933; -.
DR PathwayCommons; Q6NVV7; -.
DR SignaLink; Q6NVV7; -.
DR BioGRID-ORCS; 150383; 9 hits in 1073 CRISPR screens.
DR ChiTaRS; CDPF1; human.
DR GenomeRNAi; 150383; -.
DR Pharos; Q6NVV7; Tdark.
DR PRO; PR:Q6NVV7; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q6NVV7; protein.
DR Bgee; ENSG00000205643; Expressed in pancreatic ductal cell and 111 other tissues.
DR ExpressionAtlas; Q6NVV7; baseline and differential.
DR Genevisible; Q6NVV7; HS.
DR InterPro; IPR042426; CDPF1.
DR InterPro; IPR018785; Cys-rich_DPF.
DR PANTHER; PTHR31849; PTHR31849; 1.
DR Pfam; PF10170; C6_DPF; 1.
DR PRINTS; PR01995; UPF0595.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..123
FT /note="Cysteine-rich DPF motif domain-containing protein 1"
FT /id="PRO_0000341360"
FT REGION 102..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 5
FT /note="V -> A (in dbSNP:rs9627281)"
FT /id="VAR_044058"
FT VARIANT 70
FT /note="L -> R (in dbSNP:rs55641018)"
FT /id="VAR_062237"
FT CONFLICT 103
FT /note="Q -> R (in Ref. 3; AAH45796)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 123 AA; 13877 MW; 87E30A594058235F CRC64;
MASHVECRPL GVFECELCTL TAPYSYVGQK PPNTQSMVLL EESYVMKDPF TSDKDRFLVL
GSCCSLCSRL VCVGPECSLF YSKRFCLPCV RENINAFPQE IRQDLEKRKA PSKRTPSQPG
SRT
