CDR1_HUMAN
ID CDR1_HUMAN Reviewed; 262 AA.
AC P51861; Q5JXH6;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Cerebellar degeneration-related antigen 1;
DE AltName: Full=CDR34;
GN Name=CDR1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2326268; DOI=10.1073/pnas.87.8.3077;
RA Chen Y.-T., Rettig W.J., Yenamandra A.K., Kozak C.A., Chaganti R.S.,
RA Posner J.B., Old L.J.;
RT "Cerebellar degeneration-related antigen: a highly conserved
RT neuroectodermal marker mapped to chromosomes X in human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 87:3077-3081(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3474619; DOI=10.1073/pnas.84.13.4552;
RA Dropcho E.J., Chen Y.-T., Posner J.B., Old L.J.;
RT "Cloning of a brain protein identified by autoantibodies from a patient
RT with paraneoplastic cerebellar degeneration.";
RL Proc. Natl. Acad. Sci. U.S.A. 84:4552-4556(1987).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC P51861; P53365: ARFIP2; NbExp=3; IntAct=EBI-2836538, EBI-638194;
CC P51861; Q96LK0: CEP19; NbExp=3; IntAct=EBI-2836538, EBI-741885;
CC P51861; Q9ULP0-2: NDRG4; NbExp=3; IntAct=EBI-2836538, EBI-11978907;
CC P51861; P43378: PTPN9; NbExp=3; IntAct=EBI-2836538, EBI-742898;
CC P51861; O75800: ZMYND10; NbExp=6; IntAct=EBI-2836538, EBI-747061;
CC -!- TISSUE SPECIFICITY: Brain; predominantly expressed in normal
CC neuroectodermal tissues and in certain malignant tumors.
CC -!- MISCELLANEOUS: Autoantibodies against CDR1 are found in patients with
CC paraneoplastic cerebellar degeneration.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA51962.1; Type=Miscellaneous discrepancy; Note=Frameshifts in positions 134, 176.; Evidence={ECO:0000305};
CC Sequence=AAA52472.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; M31423; AAA51962.1; ALT_SEQ; Genomic_DNA.
DR EMBL; M16965; AAA52472.1; ALT_FRAME; mRNA.
DR EMBL; AL078639; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC113472; AAI13473.1; -; mRNA.
DR EMBL; BC113474; AAI13475.1; -; mRNA.
DR PIR; A29770; A29770.
DR RefSeq; NP_004056.2; NM_004065.2.
DR AlphaFoldDB; P51861; -.
DR BioGRID; 107469; 5.
DR IntAct; P51861; 7.
DR iPTMnet; P51861; -.
DR PhosphoSitePlus; P51861; -.
DR BioMuta; CDR1; -.
DR DMDM; 160380504; -.
DR PaxDb; P51861; -.
DR PeptideAtlas; P51861; -.
DR PRIDE; P51861; -.
DR ProteomicsDB; 56440; -.
DR Antibodypedia; 82643; 13 antibodies from 8 providers.
DR DNASU; 1038; -.
DR Ensembl; ENST00000674533.1; ENSP00000501885.1; ENSG00000288642.1.
DR GeneID; 1038; -.
DR UCSC; uc004fbg.2; human.
DR CTD; 1038; -.
DR DisGeNET; 1038; -.
DR GeneCards; CDR1; -.
DR HGNC; HGNC:1798; CDR1.
DR HPA; ENSG00000288642; Tissue enriched (brain).
DR MIM; 302650; gene.
DR neXtProt; NX_P51861; -.
DR PharmGKB; PA26330; -.
DR VEuPathDB; HostDB:ENSG00000288642; -.
DR eggNOG; ENOG502SGZK; Eukaryota.
DR GeneTree; ENSGT00390000013647; -.
DR HOGENOM; CLU_1109152_0_0_1; -.
DR InParanoid; P51861; -.
DR OMA; KTWISFW; -.
DR OrthoDB; 1306518at2759; -.
DR PhylomeDB; P51861; -.
DR PathwayCommons; P51861; -.
DR SignaLink; P51861; -.
DR BioGRID-ORCS; 1038; 12 hits in 692 CRISPR screens.
DR ChiTaRS; CDR1; human.
DR GeneWiki; CDR1_(gene); -.
DR GenomeRNAi; 1038; -.
DR Pharos; P51861; Tbio.
DR PRO; PR:P51861; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; P51861; protein.
DR Bgee; ENSG00000288642; Expressed in tendon of biceps brachii and 130 other tissues.
DR Genevisible; P51861; HS.
PE 1: Evidence at protein level;
KW Reference proteome; Repeat.
FT CHAIN 1..262
FT /note="Cerebellar degeneration-related antigen 1"
FT /id="PRO_0000089455"
FT REPEAT 3..8
FT /note="1"
FT REPEAT 9..14
FT /note="2"
FT REPEAT 15..20
FT /note="3"
FT REPEAT 21..26
FT /note="4"
FT REPEAT 27..32
FT /note="5"
FT REPEAT 33..38
FT /note="6"
FT REPEAT 39..44
FT /note="7"
FT REPEAT 45..50
FT /note="8"
FT REPEAT 51..56
FT /note="9"
FT REPEAT 57..62
FT /note="10"
FT REPEAT 63..68
FT /note="11"
FT REPEAT 69..74
FT /note="12"
FT REPEAT 75..80
FT /note="13"
FT REPEAT 81..86
FT /note="14"
FT REPEAT 87..92
FT /note="15"
FT REPEAT 93..98
FT /note="16"
FT REPEAT 99..104
FT /note="17"
FT REPEAT 105..110
FT /note="18"
FT REPEAT 111..116
FT /note="19"
FT REPEAT 117..122
FT /note="20"
FT REPEAT 123..128
FT /note="21"
FT REPEAT 129..134
FT /note="22"
FT REPEAT 135..140
FT /note="23"
FT REPEAT 141..146
FT /note="1"
FT REPEAT 147..152
FT /note="2"
FT REPEAT 153..158
FT /note="3"
FT REPEAT 159..164
FT /note="4"
FT REPEAT 165..170
FT /note="5"
FT REPEAT 171..176
FT /note="6"
FT REPEAT 177..182
FT /note="1"
FT REPEAT 183..188
FT /note="2"
FT REPEAT 189..194
FT /note="3"
FT REPEAT 195..200
FT /note="4"
FT REPEAT 201..206
FT /note="5"
FT REGION 3..140
FT /note="23 X 6 AA approximate repeats"
FT REGION 141..176
FT /note="6 X 6 AA approximate repeats"
FT REGION 177..206
FT /note="5 X 6 AA approximate repeats"
SQ SEQUENCE 262 AA; 31279 MW; 08EB318075AEE356 CRC64;
MAWLEDVDFL EDVPLLEDIP LLEDVPLLED VPLLEDTSRL EDINLMEDMA LLEDVDLLED
TDFLEDLDFS EAMDLREDKD FLEDMDSLED MALLEDVDLL EDTDFLEDPD FLEAIDLRED
KDFLEDMDSL EDLEAIGRCG FSGRHGFFGR RRFSGRPKLS GRLGLLGRRG FSGRLGGYWK
TWIFWKTWIF WKTWIFRKTY IGWKTWIFSG RCGLTGRPGF GGRRRFFWKT LTDWKTWISF
WKTLIDWKTW ISFWKTLIDW KI
