CDR2L_HUMAN
ID CDR2L_HUMAN Reviewed; 465 AA.
AC Q86X02; B4DFA7; Q15175;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Cerebellar degeneration-related protein 2-like;
DE AltName: Full=Paraneoplastic 62 kDa antigen;
GN Name=CDR2L; Synonyms=HUMPPA;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Fathallah-Shaykh H.M., Finizio J., Ho A., Rosenblum M., Posner J.;
RT "Cloning and characterization of a second leucine zipper protein recognized
RT by the sera of the patients with antibody associated paraneoplastic
RT cerebellar degeneration.";
RL Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-308, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18220336; DOI=10.1021/pr0705441;
RA Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III;
RT "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient
RT phosphoproteomic analysis.";
RL J. Proteome Res. 7:1346-1351(2008).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-318 AND SER-344, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q86X02; X5D778: ANKRD11; NbExp=3; IntAct=EBI-11063830, EBI-17183751;
CC Q86X02; Q13515: BFSP2; NbExp=4; IntAct=EBI-11063830, EBI-10229433;
CC Q86X02; Q8TAB5: C1orf216; NbExp=3; IntAct=EBI-11063830, EBI-747505;
CC Q86X02; Q504U0: C4orf46; NbExp=8; IntAct=EBI-11063830, EBI-6657981;
CC Q86X02; Q8IYE0: CCDC146; NbExp=3; IntAct=EBI-11063830, EBI-10749669;
CC Q86X02; Q494R4-2: CCDC153; NbExp=3; IntAct=EBI-11063830, EBI-11974185;
CC Q86X02; Q8N715: CCDC185; NbExp=3; IntAct=EBI-11063830, EBI-740814;
CC Q86X02; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-11063830, EBI-10175300;
CC Q86X02; Q01850: CDR2; NbExp=5; IntAct=EBI-11063830, EBI-1181367;
CC Q86X02; Q86X02: CDR2L; NbExp=4; IntAct=EBI-11063830, EBI-11063830;
CC Q86X02; P10606: COX5B; NbExp=3; IntAct=EBI-11063830, EBI-1053725;
CC Q86X02; Q08426: EHHADH; NbExp=3; IntAct=EBI-11063830, EBI-2339219;
CC Q86X02; Q14241: ELOA; NbExp=3; IntAct=EBI-11063830, EBI-742350;
CC Q86X02; Q9NVQ4-2: FAIM; NbExp=6; IntAct=EBI-11063830, EBI-12039347;
CC Q86X02; Q3B820: FAM161A; NbExp=3; IntAct=EBI-11063830, EBI-719941;
CC Q86X02; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-11063830, EBI-7225287;
CC Q86X02; Q9NVL1-2: FAM86C1P; NbExp=3; IntAct=EBI-11063830, EBI-12845222;
CC Q86X02; P56524-2: HDAC4; NbExp=3; IntAct=EBI-11063830, EBI-11953488;
CC Q86X02; O75031: HSF2BP; NbExp=3; IntAct=EBI-11063830, EBI-7116203;
CC Q86X02; Q9C086: INO80B; NbExp=3; IntAct=EBI-11063830, EBI-715611;
CC Q86X02; Q15323: KRT31; NbExp=3; IntAct=EBI-11063830, EBI-948001;
CC Q86X02; Q3LI77: KRTAP13-4; NbExp=3; IntAct=EBI-11063830, EBI-11953996;
CC Q86X02; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-11063830, EBI-726510;
CC Q86X02; Q14696: MESD; NbExp=3; IntAct=EBI-11063830, EBI-6165891;
CC Q86X02; Q8IVT4: MGC50722; NbExp=3; IntAct=EBI-11063830, EBI-14086479;
CC Q86X02; O43482: OIP5; NbExp=3; IntAct=EBI-11063830, EBI-536879;
CC Q86X02; Q6NYC8: PPP1R18; NbExp=3; IntAct=EBI-11063830, EBI-2557469;
CC Q86X02; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-11063830, EBI-1567797;
CC Q86X02; P61289: PSME3; NbExp=3; IntAct=EBI-11063830, EBI-355546;
CC Q86X02; Q86YV0: RASAL3; NbExp=3; IntAct=EBI-11063830, EBI-3437896;
CC Q86X02; Q9Y272: RASD1; NbExp=3; IntAct=EBI-11063830, EBI-740818;
CC Q86X02; Q04864-2: REL; NbExp=3; IntAct=EBI-11063830, EBI-10829018;
CC Q86X02; Q6NUQ1: RINT1; NbExp=3; IntAct=EBI-11063830, EBI-726876;
CC Q86X02; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-11063830, EBI-748391;
CC Q86X02; Q9H788: SH2D4A; NbExp=3; IntAct=EBI-11063830, EBI-747035;
CC Q86X02; Q8NCR6: SMRP1; NbExp=3; IntAct=EBI-11063830, EBI-10269322;
CC Q86X02; O43609: SPRY1; NbExp=3; IntAct=EBI-11063830, EBI-3866665;
CC Q86X02; O75558: STX11; NbExp=3; IntAct=EBI-11063830, EBI-714135;
CC Q86X02; Q969Z0: TBRG4; NbExp=3; IntAct=EBI-11063830, EBI-702328;
CC Q86X02; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-11063830, EBI-11955057;
CC Q86X02; Q9BT92: TCHP; NbExp=3; IntAct=EBI-11063830, EBI-740781;
CC Q86X02; Q8TDR4: TCP10L; NbExp=3; IntAct=EBI-11063830, EBI-3923210;
CC Q86X02; Q9UBB9: TFIP11; NbExp=3; IntAct=EBI-11063830, EBI-1105213;
CC Q86X02; Q3SY00: TSGA10IP; NbExp=6; IntAct=EBI-11063830, EBI-10241197;
CC Q86X02; Q7KZS0: UBE2I; NbExp=3; IntAct=EBI-11063830, EBI-10180829;
CC Q86X02; B2RXF5: ZBTB42; NbExp=3; IntAct=EBI-11063830, EBI-12287587;
CC Q86X02; P17023: ZNF19; NbExp=3; IntAct=EBI-11063830, EBI-12884200;
CC Q86X02; P15622-3: ZNF250; NbExp=3; IntAct=EBI-11063830, EBI-10177272;
CC Q86X02; P13682: ZNF35; NbExp=3; IntAct=EBI-11063830, EBI-11041653;
CC Q86X02; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-11063830, EBI-740727;
CC Q86X02; Q7Z3I7: ZNF572; NbExp=3; IntAct=EBI-11063830, EBI-10172590;
CC Q86X02; Q9UEG4: ZNF629; NbExp=3; IntAct=EBI-11063830, EBI-9977294;
CC Q86X02; Q5T619: ZNF648; NbExp=3; IntAct=EBI-11063830, EBI-11985915;
CC Q86X02; Q8N720: ZNF655; NbExp=3; IntAct=EBI-11063830, EBI-625509;
CC Q86X02; Q96BR6: ZNF669; NbExp=3; IntAct=EBI-11063830, EBI-12006574;
CC Q86X02; P0C7X2: ZNF688; NbExp=3; IntAct=EBI-11063830, EBI-4395732;
CC Q86X02; P51504: ZNF80; NbExp=3; IntAct=EBI-11063830, EBI-12013828;
CC Q86X02; Q9Y2P0: ZNF835; NbExp=3; IntAct=EBI-11063830, EBI-5667516;
CC Q86X02; P10073: ZSCAN22; NbExp=3; IntAct=EBI-11063830, EBI-10178224;
CC Q86X02; Q3MJ62: ZSCAN23; NbExp=3; IntAct=EBI-11063830, EBI-5667532;
CC Q86X02; Q16670: ZSCAN26; NbExp=3; IntAct=EBI-11063830, EBI-3920053;
CC -!- SIMILARITY: Belongs to the CDR2 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA91850.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAH47534.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; L02867; AAA91850.1; ALT_FRAME; mRNA.
DR EMBL; AK294006; BAG57368.1; -; mRNA.
DR EMBL; CH471099; EAW89224.1; -; Genomic_DNA.
DR EMBL; BC047534; AAH47534.1; ALT_INIT; mRNA.
DR CCDS; CCDS11710.2; -.
DR RefSeq; NP_055418.2; NM_014603.2.
DR AlphaFoldDB; Q86X02; -.
DR SMR; Q86X02; -.
DR BioGRID; 119060; 96.
DR IntAct; Q86X02; 66.
DR MINT; Q86X02; -.
DR STRING; 9606.ENSP00000336587; -.
DR GlyGen; Q86X02; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q86X02; -.
DR PhosphoSitePlus; Q86X02; -.
DR BioMuta; CDR2L; -.
DR DMDM; 160017566; -.
DR EPD; Q86X02; -.
DR jPOST; Q86X02; -.
DR MassIVE; Q86X02; -.
DR MaxQB; Q86X02; -.
DR PaxDb; Q86X02; -.
DR PeptideAtlas; Q86X02; -.
DR PRIDE; Q86X02; -.
DR ProteomicsDB; 70217; -.
DR Antibodypedia; 19492; 103 antibodies from 20 providers.
DR DNASU; 30850; -.
DR Ensembl; ENST00000337231.5; ENSP00000336587.5; ENSG00000109089.7.
DR GeneID; 30850; -.
DR KEGG; hsa:30850; -.
DR MANE-Select; ENST00000337231.5; ENSP00000336587.5; NM_014603.3; NP_055418.2.
DR UCSC; uc002jml.5; human.
DR CTD; 30850; -.
DR DisGeNET; 30850; -.
DR GeneCards; CDR2L; -.
DR HGNC; HGNC:29999; CDR2L.
DR HPA; ENSG00000109089; Tissue enhanced (brain).
DR neXtProt; NX_Q86X02; -.
DR OpenTargets; ENSG00000109089; -.
DR PharmGKB; PA142672137; -.
DR VEuPathDB; HostDB:ENSG00000109089; -.
DR eggNOG; ENOG502QRN3; Eukaryota.
DR GeneTree; ENSGT00390000018570; -.
DR HOGENOM; CLU_048751_0_0_1; -.
DR InParanoid; Q86X02; -.
DR OMA; WPKTQPA; -.
DR OrthoDB; 1101523at2759; -.
DR PhylomeDB; Q86X02; -.
DR TreeFam; TF326183; -.
DR PathwayCommons; Q86X02; -.
DR SignaLink; Q86X02; -.
DR BioGRID-ORCS; 30850; 16 hits in 1077 CRISPR screens.
DR ChiTaRS; CDR2L; human.
DR GenomeRNAi; 30850; -.
DR Pharos; Q86X02; Tbio.
DR PRO; PR:Q86X02; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q86X02; protein.
DR Bgee; ENSG00000109089; Expressed in inferior vagus X ganglion and 180 other tissues.
DR ExpressionAtlas; Q86X02; baseline and differential.
DR Genevisible; Q86X02; HS.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR InterPro; IPR026079; CDR2.
DR PANTHER; PTHR19232; PTHR19232; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..465
FT /note="Cerebellar degeneration-related protein 2-like"
FT /id="PRO_0000307234"
FT REGION 282..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 38..143
FT /evidence="ECO:0000255"
FT COILED 188..265
FT /evidence="ECO:0000255"
FT COILED 350..377
FT /evidence="ECO:0000255"
FT COMPBIAS 395..417
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 308
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18220336"
FT MOD_RES 318
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 344
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VARIANT 300
FT /note="D -> E (in dbSNP:rs36057512)"
FT /id="VAR_035384"
FT CONFLICT 383
FT /note="H -> D (in Ref. 1; AAA91850)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 465 AA; 53010 MW; E9231122B2378B71 CRC64;
MRRAAGMEDF SAEEEESWYD QQDLEQDLHL AAELGKTLLE RNKELEGSLQ QMYSTNEEQV
QEIEYLTKQL DTLRHVNEQH AKVYEQLDLT ARDLELTNHR LVLESKAAQQ KIHGLTETIE
RLQAQVEELQ AQVEQLRGLE QLRVLREKRE RRRTIHTFPC LKELCTSPRC KDAFRLHSSS
LELGPRPLEQ ENERLQTLVG ALRSQVSQER QRKERAEREY TAVLQEYSEL ERQLCEMEAC
RLRVQELEAE LLELQQMKQA KTYLLGPDDH LAEALLAPLT QAPEADDPQP GRGDDLGAQD
GVSSPAASPG HVVRKSCSDT ALNAIVAKDP ASRHAGNLTL HANSVRKRGM SILREVDEQY
HALLEKYEEL LSKCRQHGAG VRHAGVQTSR PISRDSSWRD LRGGEEGQGE VKAGEKSLSQ
HVEAVDKRLE QSQPEYKALF KEIFSRIQKT KADINATKVK THSSK
