ID   CDR2L_MOUSE             Reviewed;         465 AA.
AC   A2A6T1;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Cerebellar degeneration-related protein 2-like;
GN   Name=Cdr2l; Synonyms=Gm21;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-308; SER-318 AND SER-407, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Heart, Kidney, Lung, and Spleen;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SIMILARITY: Belongs to the CDR2 family. {ECO:0000305}.
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DR   EMBL; AL603828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS36371.1; -.
DR   RefSeq; NP_001074398.1; NM_001080929.1.
DR   AlphaFoldDB; A2A6T1; -.
DR   SMR; A2A6T1; -.
DR   STRING; 10090.ENSMUSP00000052096; -.
DR   iPTMnet; A2A6T1; -.
DR   PhosphoSitePlus; A2A6T1; -.
DR   jPOST; A2A6T1; -.
DR   MaxQB; A2A6T1; -.
DR   PaxDb; A2A6T1; -.
DR   PeptideAtlas; A2A6T1; -.
DR   PRIDE; A2A6T1; -.
DR   ProteomicsDB; 281358; -.
DR   Antibodypedia; 19492; 103 antibodies from 20 providers.
DR   Ensembl; ENSMUST00000053288; ENSMUSP00000052096; ENSMUSG00000050910.
DR   GeneID; 237988; -.
DR   KEGG; mmu:237988; -.
DR   UCSC; uc007mhi.1; mouse.
DR   CTD; 30850; -.
DR   MGI; MGI:2684867; Cdr2l.
DR   VEuPathDB; HostDB:ENSMUSG00000050910; -.
DR   eggNOG; ENOG502QRN3; Eukaryota.
DR   GeneTree; ENSGT00390000018570; -.
DR   HOGENOM; CLU_048751_0_0_1; -.
DR   InParanoid; A2A6T1; -.
DR   OMA; WPKTQPA; -.
DR   OrthoDB; 1101523at2759; -.
DR   PhylomeDB; A2A6T1; -.
DR   TreeFam; TF326183; -.
DR   BioGRID-ORCS; 237988; 5 hits in 78 CRISPR screens.
DR   ChiTaRS; Cdr2l; mouse.
DR   PRO; PR:A2A6T1; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; A2A6T1; protein.
DR   Bgee; ENSMUSG00000050910; Expressed in choroid plexus of fourth ventricle and 245 other tissues.
DR   Genevisible; A2A6T1; MM.
DR   GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR   InterPro; IPR026079; CDR2.
DR   PANTHER; PTHR19232; PTHR19232; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Phosphoprotein; Reference proteome.
FT   CHAIN           1..465
FT                   /note="Cerebellar degeneration-related protein 2-like"
FT                   /id="PRO_0000307235"
FT   REGION          282..315
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          382..421
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          31..64
FT                   /evidence="ECO:0000255"
FT   COILED          91..142
FT                   /evidence="ECO:0000255"
FT   COILED          188..266
FT                   /evidence="ECO:0000255"
FT   COILED          350..377
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        292..315
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        399..421
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         308
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         318
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         344
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q86X02"
FT   MOD_RES         407
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
SQ   SEQUENCE   465 AA;  53213 MW;  F63244370A51DDA9 CRC64;
     MRRAAGMEDY SAEEEESWYD HQDLEQDLHL AAELGKTLLE RNKELEESLQ QMYSTNEEQV
     HEIEYLTKQL DTLRLVNEQH AKVYEQLDLT ARDLELTNQR LVMESKAAQQ KIHGLTETIE
     RLQSQVEELQ AQVEQLRGLE QLRIRREKRE RRRTIHTFPC LKELCTSSRC EDAFRLHSSS
     LELGPRPLEQ ENERLQTLVG VLRSQVSQER QRKERAEREY TVVLQEYTEL ERQLCEMEGC
     RLRVQELEAE LLELQQMKQA KTYLLAREEH LAEALLAPLT QAPEADDPQP GSGDDSNAQD
     GVSSPAASPS HAVRKSCSDT ALNAIVAKDP ASRHAGNLTL HANSVRRRGM SILREVDEQY
     HALLEKYEEL LSKCRQHGAG VRHAGVQTSR PISRDSSWRD LLGGEESPGE GKAGEKSLSQ
     HVEAVDKRLE QSQPEYKALF KEIFARIQKT KADINATKVK THSSK