CDR2_HUMAN
ID CDR2_HUMAN Reviewed; 454 AA.
AC Q01850; A8K8A8; Q13977;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 2.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Cerebellar degeneration-related protein 2;
DE AltName: Full=Major Yo paraneoplastic antigen;
DE AltName: Full=Paraneoplastic cerebellar degeneration-associated antigen;
GN Name=CDR2; Synonyms=PCD17;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2014264; DOI=10.1073/pnas.88.8.3451;
RA Fathallah-Shaykh H., Wolf S., Wong E., Posner J.B., Furneaux H.M.;
RT "Cloning of a leucine-zipper protein recognized by the sera of patients
RT with antibody-associated paraneoplastic cerebellar degeneration.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:3451-3454(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 6-454.
RC TISSUE=Cerebellum;
RX PubMed=2260856; DOI=10.1002/ana.410280515;
RA Sakai K., Mitchell D.J., Tsukamoto T., Steinman L.;
RT "Isolation of a complementary DNA clone encoding an autoantigen recognized
RT by an anti-neuronal cell antibody from a patient with paraneoplastic
RT cerebellar degeneration.";
RL Ann. Neurol. 28:692-698(1990).
RN [6]
RP ERRATUM OF PUBMED:2260856.
RX PubMed=1763903; DOI=10.1002/ana.410300523;
RA Sakai K., Mitchell D.J., Tsukamoto T., Steinman L.;
RL Ann. Neurol. 30:738-738(1991).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-311, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- INTERACTION:
CC Q01850; Q9Y2J4-4: AMOTL2; NbExp=3; IntAct=EBI-1181367, EBI-10187270;
CC Q01850; Q96IX9: ANKRD36BP1; NbExp=3; IntAct=EBI-1181367, EBI-744859;
CC Q01850; P29972: AQP1; NbExp=3; IntAct=EBI-1181367, EBI-745213;
CC Q01850; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-1181367, EBI-745073;
CC Q01850; Q8TAB5: C1orf216; NbExp=6; IntAct=EBI-1181367, EBI-747505;
CC Q01850; Q53TS8: C2CD6; NbExp=3; IntAct=EBI-1181367, EBI-739879;
CC Q01850; Q504U0: C4orf46; NbExp=7; IntAct=EBI-1181367, EBI-6657981;
CC Q01850; Q96HB5: CCDC120; NbExp=3; IntAct=EBI-1181367, EBI-744556;
CC Q01850; Q8IYE1: CCDC13; NbExp=3; IntAct=EBI-1181367, EBI-10961312;
CC Q01850; Q8IYE0: CCDC146; NbExp=3; IntAct=EBI-1181367, EBI-10749669;
CC Q01850; Q494R4: CCDC153; NbExp=3; IntAct=EBI-1181367, EBI-10241443;
CC Q01850; Q494R4-2: CCDC153; NbExp=3; IntAct=EBI-1181367, EBI-11974185;
CC Q01850; Q9NVE4: CCDC87; NbExp=3; IntAct=EBI-1181367, EBI-749261;
CC Q01850; Q8TD31-3: CCHCR1; NbExp=6; IntAct=EBI-1181367, EBI-10175300;
CC Q01850; Q07002: CDK18; NbExp=3; IntAct=EBI-1181367, EBI-746238;
CC Q01850; Q86X02: CDR2L; NbExp=5; IntAct=EBI-1181367, EBI-11063830;
CC Q01850; Q8IYX8-2: CEP57L1; NbExp=3; IntAct=EBI-1181367, EBI-10181988;
CC Q01850; Q9UKJ5: CHIC2; NbExp=7; IntAct=EBI-1181367, EBI-741528;
CC Q01850; P10606: COX5B; NbExp=7; IntAct=EBI-1181367, EBI-1053725;
CC Q01850; O60573: EIF4E2; NbExp=3; IntAct=EBI-1181367, EBI-398610;
CC Q01850; Q9H0I2: ENKD1; NbExp=6; IntAct=EBI-1181367, EBI-744099;
CC Q01850; Q9BQ89: FAM110A; NbExp=3; IntAct=EBI-1181367, EBI-1752811;
CC Q01850; Q3B820: FAM161A; NbExp=6; IntAct=EBI-1181367, EBI-719941;
CC Q01850; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-1181367, EBI-7225287;
CC Q01850; Q9Y247: FAM50B; NbExp=3; IntAct=EBI-1181367, EBI-742802;
CC Q01850; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-1181367, EBI-6658203;
CC Q01850; O95995: GAS8; NbExp=3; IntAct=EBI-1181367, EBI-1052570;
CC Q01850; P55040: GEM; NbExp=3; IntAct=EBI-1181367, EBI-744104;
CC Q01850; Q96CS2: HAUS1; NbExp=3; IntAct=EBI-1181367, EBI-2514791;
CC Q01850; P56524: HDAC4; NbExp=3; IntAct=EBI-1181367, EBI-308629;
CC Q01850; P56524-2: HDAC4; NbExp=3; IntAct=EBI-1181367, EBI-11953488;
CC Q01850; A0A0S2Z4Q4: HGS; NbExp=3; IntAct=EBI-1181367, EBI-16429135;
CC Q01850; O14964: HGS; NbExp=6; IntAct=EBI-1181367, EBI-740220;
CC Q01850; Q9C086: INO80B; NbExp=3; IntAct=EBI-1181367, EBI-715611;
CC Q01850; Q7Z3B3: KANSL1; NbExp=4; IntAct=EBI-1181367, EBI-740244;
CC Q01850; P33176: KIF5B; NbExp=3; IntAct=EBI-1181367, EBI-355878;
CC Q01850; Q9BVG8: KIFC3; NbExp=3; IntAct=EBI-1181367, EBI-2125614;
CC Q01850; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-1181367, EBI-14069005;
CC Q01850; Q96BZ8: LENG1; NbExp=6; IntAct=EBI-1181367, EBI-726510;
CC Q01850; Q96GY3: LIN37; NbExp=3; IntAct=EBI-1181367, EBI-748884;
CC Q01850; Q8IVT4: MGC50722; NbExp=3; IntAct=EBI-1181367, EBI-14086479;
CC Q01850; Q8IY33: MICALL2; NbExp=3; IntAct=EBI-1181367, EBI-2555563;
CC Q01850; Q9NPJ1: MKKS; NbExp=3; IntAct=EBI-1181367, EBI-721319;
CC Q01850; Q8NEH6: MNS1; NbExp=3; IntAct=EBI-1181367, EBI-743811;
CC Q01850; Q15014: MORF4L2; NbExp=6; IntAct=EBI-1181367, EBI-399257;
CC Q01850; Q13084: MRPL28; NbExp=3; IntAct=EBI-1181367, EBI-723426;
CC Q01850; Q96HA8: NTAQ1; NbExp=4; IntAct=EBI-1181367, EBI-741158;
CC Q01850; O95190: OAZ2; NbExp=3; IntAct=EBI-1181367, EBI-1051861;
CC Q01850; Q17RL8: PDZD4; NbExp=3; IntAct=EBI-1181367, EBI-10239064;
CC Q01850; Q16512: PKN1; NbExp=6; IntAct=EBI-1181367, EBI-602382;
CC Q01850; P54646: PRKAA2; NbExp=3; IntAct=EBI-1181367, EBI-1383852;
CC Q01850; Q99633: PRPF18; NbExp=3; IntAct=EBI-1181367, EBI-2798416;
CC Q01850; P25786: PSMA1; NbExp=3; IntAct=EBI-1181367, EBI-359352;
CC Q01850; Q9P2K3: RCOR3; NbExp=3; IntAct=EBI-1181367, EBI-743428;
CC Q01850; Q9UHP6: RSPH14; NbExp=3; IntAct=EBI-1181367, EBI-748350;
CC Q01850; Q06455-2: RUNX1T1; NbExp=3; IntAct=EBI-1181367, EBI-11984663;
CC Q01850; Q9BWG6: SCNM1; NbExp=6; IntAct=EBI-1181367, EBI-748391;
CC Q01850; Q9H788: SH2D4A; NbExp=6; IntAct=EBI-1181367, EBI-747035;
CC Q01850; Q9H788-2: SH2D4A; NbExp=3; IntAct=EBI-1181367, EBI-10308083;
CC Q01850; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-1181367, EBI-358489;
CC Q01850; Q969G3: SMARCE1; NbExp=6; IntAct=EBI-1181367, EBI-455078;
CC Q01850; Q9NU19: TBC1D22B; NbExp=4; IntAct=EBI-1181367, EBI-8787464;
CC Q01850; Q9BT92: TCHP; NbExp=8; IntAct=EBI-1181367, EBI-740781;
CC Q01850; Q15561: TEAD4; NbExp=3; IntAct=EBI-1181367, EBI-747736;
CC Q01850; O15482: TEX28P2; NbExp=3; IntAct=EBI-1181367, EBI-751954;
CC Q01850; P36406: TRIM23; NbExp=6; IntAct=EBI-1181367, EBI-740098;
CC Q01850; Q8N7C3: TRIML2; NbExp=3; IntAct=EBI-1181367, EBI-11059915;
CC Q01850; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-1181367, EBI-10241197;
CC Q01850; Q5W5X9-3: TTC23; NbExp=3; IntAct=EBI-1181367, EBI-9090990;
CC Q01850; P02766: TTR; NbExp=3; IntAct=EBI-1181367, EBI-711909;
CC Q01850; P40222: TXLNA; NbExp=7; IntAct=EBI-1181367, EBI-359793;
CC Q01850; Q8N3L3: TXLNB; NbExp=3; IntAct=EBI-1181367, EBI-6116822;
CC Q01850; P0CB47: UBTFL1; NbExp=3; IntAct=EBI-1181367, EBI-17208936;
CC Q01850; A0A0S2Z6H0: ZGPAT; NbExp=4; IntAct=EBI-1181367, EBI-16428984;
CC Q01850; Q8N5A5-2: ZGPAT; NbExp=6; IntAct=EBI-1181367, EBI-10183064;
CC Q01850; Q96NC0: ZMAT2; NbExp=3; IntAct=EBI-1181367, EBI-2682299;
CC Q01850; P15622-3: ZNF250; NbExp=3; IntAct=EBI-1181367, EBI-10177272;
CC Q01850; P13682: ZNF35; NbExp=3; IntAct=EBI-1181367, EBI-11041653;
CC Q01850; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-1181367, EBI-740727;
CC -!- SIMILARITY: Belongs to the CDR2 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA51961.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAB20813.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAA02360.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; M63256; AAA51961.1; ALT_SEQ; mRNA.
DR EMBL; AK292273; BAF84962.1; -; mRNA.
DR EMBL; CH471249; EAW50609.1; -; Genomic_DNA.
DR EMBL; BC017503; AAH17503.2; -; mRNA.
DR EMBL; D12981; BAA02360.1; ALT_INIT; mRNA.
DR EMBL; S78388; AAB20813.1; ALT_INIT; mRNA.
DR CCDS; CCDS32404.1; -.
DR PIR; A40448; A40448.
DR RefSeq; NP_001793.1; NM_001802.1.
DR RefSeq; XP_005276559.1; XM_005276502.1.
DR AlphaFoldDB; Q01850; -.
DR SMR; Q01850; -.
DR BioGRID; 107470; 128.
DR IntAct; Q01850; 108.
DR MINT; Q01850; -.
DR STRING; 9606.ENSP00000268383; -.
DR GlyGen; Q01850; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q01850; -.
DR PhosphoSitePlus; Q01850; -.
DR BioMuta; CDR2; -.
DR DMDM; 68839004; -.
DR EPD; Q01850; -.
DR jPOST; Q01850; -.
DR MassIVE; Q01850; -.
DR MaxQB; Q01850; -.
DR PaxDb; Q01850; -.
DR PeptideAtlas; Q01850; -.
DR PRIDE; Q01850; -.
DR ProteomicsDB; 58009; -.
DR Antibodypedia; 12516; 398 antibodies from 29 providers.
DR DNASU; 1039; -.
DR Ensembl; ENST00000268383.7; ENSP00000268383.2; ENSG00000140743.8.
DR GeneID; 1039; -.
DR KEGG; hsa:1039; -.
DR MANE-Select; ENST00000268383.7; ENSP00000268383.2; NM_001802.2; NP_001793.1.
DR UCSC; uc002dkn.3; human.
DR CTD; 1039; -.
DR DisGeNET; 1039; -.
DR GeneCards; CDR2; -.
DR HGNC; HGNC:1799; CDR2.
DR HPA; ENSG00000140743; Low tissue specificity.
DR MIM; 117340; gene.
DR neXtProt; NX_Q01850; -.
DR OpenTargets; ENSG00000140743; -.
DR PharmGKB; PA26331; -.
DR VEuPathDB; HostDB:ENSG00000140743; -.
DR eggNOG; ENOG502QUPP; Eukaryota.
DR GeneTree; ENSGT00390000018570; -.
DR HOGENOM; CLU_048751_0_0_1; -.
DR InParanoid; Q01850; -.
DR OMA; FKEHSQS; -.
DR OrthoDB; 1101523at2759; -.
DR PhylomeDB; Q01850; -.
DR TreeFam; TF326183; -.
DR PathwayCommons; Q01850; -.
DR SignaLink; Q01850; -.
DR SIGNOR; Q01850; -.
DR BioGRID-ORCS; 1039; 15 hits in 1087 CRISPR screens.
DR ChiTaRS; CDR2; human.
DR GeneWiki; CDR2_(gene); -.
DR Pharos; Q01850; Tbio.
DR PRO; PR:Q01850; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q01850; protein.
DR Bgee; ENSG00000140743; Expressed in secondary oocyte and 169 other tissues.
DR ExpressionAtlas; Q01850; baseline and differential.
DR Genevisible; Q01850; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR InterPro; IPR026079; CDR2.
DR PANTHER; PTHR19232; PTHR19232; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..454
FT /note="Cerebellar degeneration-related protein 2"
FT /id="PRO_0000089456"
FT REGION 134..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 44..142
FT /evidence="ECO:0000255"
FT COILED 192..265
FT /evidence="ECO:0000255"
FT COILED 346..380
FT /evidence="ECO:0000255"
FT MOD_RES 311
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT CONFLICT 6
FT /note="L -> R (in Ref. 5; AAB20813)"
FT /evidence="ECO:0000305"
FT CONFLICT 7
FT /note="V -> T (in Ref. 5; AAB20813/BAA02360)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 454 AA; 51855 MW; A7615F2C5AE08D2C CRC64;
MLAENLVEEF EMKEDEPWYD HQDLQQDLQL AAELGKTLLD RNTELEDSVQ QMYTTNQEQL
QEIEYLTKQV ELLRQMNEQH AKVYEQLDVT ARELEETNQK LVADSKASQQ KILSLTETIE
CLQTNIDHLQ SQVEELKSSG QGRRSPGKCD QEKPAPSFAC LKELYDLRQH FVYDHVFAEK
ITSLQGQPSP DEEENEHLKK TVTMLQAQLS LERQKRVTME EEYGLVLKEN SELEQQLGAT
GAYRARALEL EAEVAEMRQM LQSEHPFVNG VEKLVPDSLY VPFKEPSQSL LEEMFLTVPE
SHRKPLKRSS SETILSSLAG SDIVKGHEET CIRRAKAVKQ RGISLLHEVD TQYSALKVKY
EELLKKCQEE QDSLSHKAVQ TSRAAAKDLT GVNAQSEPVA SGWELASVNP EPVSSPTTPP
EYKALFKEIF SCIKKTKQEI DEQRTKYRSL SSHS
