CDR2_MOUSE
ID CDR2_MOUSE Reviewed; 455 AA.
AC P97817; Q3UG92;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Cerebellar degeneration-related protein 2;
GN Name=Cdr2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=9006982; DOI=10.1523/jneurosci.17-04-01406.1997;
RA Corradi J.P., Yang C., Darnell J.C., Dalmau J., Darnell R.B.;
RT "A post-transcriptional regulatory mechanism restricts expression of the
RT paraneoplastic cerebellar degeneration antigen cdr2 to immune privileged
RT tissues.";
RL J. Neurosci. 17:1406-1415(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PROTEIN SEQUENCE OF 334-340, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=OF1; TISSUE=Hippocampus;
RA Lubec G., Sunyer B., Chen W.-Q.;
RL Submitted (JAN-2009) to UniProtKB.
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic brain;
RX PubMed=15345747; DOI=10.1074/mcp.m400085-mcp200;
RA Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
RT "Phosphoproteomic analysis of the developing mouse brain.";
RL Mol. Cell. Proteomics 3:1093-1101(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- TISSUE SPECIFICITY: Expressed in brain and testis (at protein level).
CC Expressed in the cerebellum, cerebral cortex, heart, lung, spleen,
CC ovary, kidney and testis. {ECO:0000269|PubMed:9006982}.
CC -!- SIMILARITY: Belongs to the CDR2 family. {ECO:0000305}.
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DR EMBL; U88588; AAC53052.1; -; mRNA.
DR EMBL; AK148057; BAE28317.1; -; mRNA.
DR EMBL; BC117530; AAI17531.1; -; mRNA.
DR EMBL; BC118511; AAI18512.1; -; mRNA.
DR CCDS; CCDS21798.1; -.
DR RefSeq; NP_031698.2; NM_007672.2.
DR AlphaFoldDB; P97817; -.
DR SMR; P97817; -.
DR BioGRID; 198660; 1.
DR STRING; 10090.ENSMUSP00000033169; -.
DR iPTMnet; P97817; -.
DR PhosphoSitePlus; P97817; -.
DR jPOST; P97817; -.
DR MaxQB; P97817; -.
DR PaxDb; P97817; -.
DR PeptideAtlas; P97817; -.
DR PRIDE; P97817; -.
DR ProteomicsDB; 283869; -.
DR Antibodypedia; 12516; 398 antibodies from 29 providers.
DR Ensembl; ENSMUST00000033169; ENSMUSP00000033169; ENSMUSG00000030878.
DR GeneID; 12585; -.
DR KEGG; mmu:12585; -.
DR UCSC; uc012ftc.2; mouse.
DR CTD; 1039; -.
DR MGI; MGI:1100885; Cdr2.
DR VEuPathDB; HostDB:ENSMUSG00000030878; -.
DR eggNOG; ENOG502QUPP; Eukaryota.
DR GeneTree; ENSGT00390000018570; -.
DR HOGENOM; CLU_048751_0_0_1; -.
DR InParanoid; P97817; -.
DR OMA; FKEHSQS; -.
DR OrthoDB; 1101523at2759; -.
DR TreeFam; TF326183; -.
DR BioGRID-ORCS; 12585; 2 hits in 71 CRISPR screens.
DR PRO; PR:P97817; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; P97817; protein.
DR Bgee; ENSMUSG00000030878; Expressed in blood and 243 other tissues.
DR ExpressionAtlas; P97817; baseline and differential.
DR Genevisible; P97817; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR InterPro; IPR026079; CDR2.
DR PANTHER; PTHR19232; PTHR19232; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Direct protein sequencing; Phosphoprotein; Reference proteome.
FT CHAIN 1..455
FT /note="Cerebellar degeneration-related protein 2"
FT /id="PRO_0000089457"
FT REGION 132..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 395..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 37..141
FT /evidence="ECO:0000255"
FT COILED 191..264
FT /evidence="ECO:0000255"
FT MOD_RES 310
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q01850"
FT CONFLICT 367..368
FT /note="QQ -> HE (in Ref. 1; AAC53052)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 455 AA; 52090 MW; 609C107493DA29F2 CRC64;
MLADNLVEEF EMEDEPWYDH RDLQQDLQLA AELGKTLLDR NTELEDSLQQ MYTTNQEQLQ
EIEYLTKQVE LLRQMNEQHA KVYEQLDVTA RELEETNQKL VAESKASQQK ILSLTETIEC
LQTNIDHLQS QVEELKSSSQ GRGRQKACDQ EKPAPSFSCL KELYDLRQHF VYDHVFAEKI
TSLQSQQSPD EEENEHLKKA VTMLQAQLSL ERKKRVSVEA EYKVVLKENS ELEQQLGATD
AYRARALELE AEVAEMRQML QAEHPFVNGV EKLVPDSLFV PFKEPSQSLL EEMFLAAPEA
PRKPLKRSSS ETALSSLAGD DIVKDHEDTC IRRAKAVKQR GISLLHEVDT QYSALKVKYE
ELLKKCQQEQ DSLSHKAVQT SRLLTRDLTG LVTQSEAGAS GWEPTPVSPE SISSPTTTPP
EYKALFKEIF SCIKKTKQEI DEQRTKYPSL SSYSY
