CDS1_SOLTU
ID CDS1_SOLTU Reviewed; 424 AA.
AC O04940;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Phosphatidate cytidylyltransferase 1 {ECO:0000303|PubMed:9085581};
DE EC=2.7.7.41 {ECO:0000269|PubMed:9085581};
DE AltName: Full=CDP-DAG synthase;
DE AltName: Full=CDP-DG synthase;
DE AltName: Full=CDP-diacylglycerol synthase;
DE Short=CDS;
DE AltName: Full=CDP-diglyceride pyrophosphorylase;
DE AltName: Full=CDP-diglyceride synthase;
DE AltName: Full=CTP:phosphatidate cytidylyltransferase;
GN Name=CDS1 {ECO:0000303|PubMed:9085581};
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, AND PATHWAY.
RC STRAIN=cv. Desiree; TISSUE=Leaf;
RX PubMed=9085581; DOI=10.1104/pp.113.3.997;
RA Kopka J., Ludewig M., Mueller-Roeber B.;
RT "Complementary DNAs encoding eukaryotic-type cytidine-5'-diphosphate-
RT diacylglycerol synthases of two plant species.";
RL Plant Physiol. 113:997-1002(1997).
CC -!- FUNCTION: May be involved in the synthesis of minor phospholipids and
CC in modulation of IP3-mediated signal transduction.
CC {ECO:0000269|PubMed:9085581}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-
CC diacyl-sn-glycerol + diphosphate; Xref=Rhea:RHEA:16229,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563,
CC ChEBI:CHEBI:58332, ChEBI:CHEBI:58608; EC=2.7.7.41;
CC Evidence={ECO:0000269|PubMed:9085581};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000250|UniProtKB:Q94A03};
CC Note=Requires a divalent cation for activity.
CC {ECO:0000250|UniProtKB:Q94A03};
CC -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-
CC diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
CC {ECO:0000269|PubMed:9085581}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Roots and sink leaves.
CC {ECO:0000269|PubMed:9085581}.
CC -!- SIMILARITY: Belongs to the CDS family. {ECO:0000305}.
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DR EMBL; X91909; CAA63004.1; -; mRNA.
DR PIR; T07366; T07366.
DR RefSeq; NP_001275147.1; NM_001288218.1.
DR AlphaFoldDB; O04940; -.
DR EnsemblPlants; RHC03H1G0115.2.1; RHC03H1G0115.2.1; RHC03H1G0115.2.
DR GeneID; 102597765; -.
DR Gramene; RHC03H1G0115.2.1; RHC03H1G0115.2.1; RHC03H1G0115.2.
DR KEGG; sot:102597765; -.
DR InParanoid; O04940; -.
DR OrthoDB; 1072976at2759; -.
DR UniPathway; UPA00557; UER00614.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004605; F:phosphatidate cytidylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0016024; P:CDP-diacylglycerol biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR000374; PC_trans.
DR InterPro; IPR016720; PC_Trfase_euk.
DR PANTHER; PTHR13773; PTHR13773; 1.
DR PIRSF; PIRSF018269; PC_trans_euk; 1.
DR PROSITE; PS01315; CDS; 1.
PE 1: Evidence at protein level;
KW Lipid biosynthesis; Lipid metabolism; Magnesium; Membrane;
KW Nucleotidyltransferase; Phospholipid biosynthesis; Phospholipid metabolism;
KW Reference proteome; Transferase; Transmembrane; Transmembrane helix.
FT CHAIN 1..424
FT /note="Phosphatidate cytidylyltransferase 1"
FT /id="PRO_0000090724"
FT TRANSMEM 60..80
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..266
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 321..341
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 369..389
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 424 AA; 49178 MW; 43B556B12F082638 CRC64;
MHNDSNSGAP GTPSGRIRRR RGSNEVPPEV VKANGNHLLV NDRSKYKSML IRAYSSVWMI
GGFAFIIYMG HLYIWAMVVV IQIFMAKELF NLLRRAHEDR HLPGFRLLNW HFFFTAMLFV
YGRMLSQRLV NTVTLDKFLY KLVGRFVKYH MVTCYFFYIA GFMWFILTLK KKMYKYQFSQ
YAWTHMILIV VFTQSAFTVA NIFEGIFWFL LPASLIVIND IAAYFFGFFF GRTPLIKLSP
KKTWEGFIGA SITTIISAFL LANMFGRFQW LTCPRKDLST GWLDCDPGPL FKPEYFTLPE
WFPAWFLSRE IAVLPVQWHA LLLGLFASII APFGGFFASG FKRAFKIKDF GDSIPGHGGM
TDRMDCQMVM AVFAYIYHQS FIVPQNLSIE MILDQIILNL TFEEQLAVYK KLGQIIQERT
FGES
