ID   CDS4_CONLT              Reviewed;          85 AA.
AC   F6JWV0;
DT   07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   25-MAY-2022, entry version 12.
DE   RecName: Full=Conotoxin Lt28.4 {ECO:0000303|PubMed:28666820};
DE   AltName: Full=Conotoxin Lt15.9 {ECO:0000312|EMBL:ADZ76487.1};
DE   Flags: Precursor;
OS   Conus litteratus (Lettered cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Elisaconus.
OX   NCBI_TaxID=89445;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=28666820; DOI=10.1016/j.peptides.2017.06.008;
RA   Lu J., Zhang K., Wang S., Sun T., Yu S., Dai Q., Liu Z.;
RT   "Cloning, expression and functional characterization of a D-superfamily
RT   conotoxin Lt28.1 with previously undescribed cysteine pattern.";
RL   Peptides 94:64-70(2017).
CC   -!- FUNCTION: Probable neurotoxin. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:28666820}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:28666820}.
CC   -!- DOMAIN: The cysteine framework is XXVIII (C-C-C-CC-C-C-C-C-C).
CC       {ECO:0000305}.
CC   -!- PTM: Contains 5 disulfide bonds. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin D superfamily. {ECO:0000305}.
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DR   EMBL; HM003929; ADZ76487.1; -; mRNA.
DR   AlphaFoldDB; F6JWV0; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Disulfide bond; Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..40
FT                   /evidence="ECO:0000305|PubMed:28666820"
FT                   /id="PRO_0000451014"
FT   CHAIN           41..85
FT                   /note="Conotoxin Lt28.4"
FT                   /evidence="ECO:0000305|PubMed:28666820"
FT                   /id="PRO_5003337630"
SQ   SEQUENCE   85 AA;  9395 MW;  81E3AAB262566FFF CRC64;
     MPKLEMMLLV LLILPLCYID AVGPPPPWNM EDEIIEHWQK LHCHEISDLT PWILCSPEPL
     CGGKGCCAQE VCDCSGTACT CPPCL