CDSA_HAEIN
ID CDSA_HAEIN Reviewed; 288 AA.
AC P44937; O32623; O32627;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Phosphatidate cytidylyltransferase;
DE EC=2.7.7.41;
DE AltName: Full=CDP-DAG synthase;
DE AltName: Full=CDP-DG synthase;
DE AltName: Full=CDP-diacylglycerol synthase;
DE Short=CDS;
DE AltName: Full=CDP-diglyceride pyrophosphorylase;
DE AltName: Full=CDP-diglyceride synthase;
DE AltName: Full=CTP:phosphatidate cytidylyltransferase;
GN Name=cdsA; Synonyms=cds; OrderedLocusNames=HI_0919;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=33, and Eagan / Serotype B;
RA Loosmore S.M., Yang Y., Coleman D.C., Shortreed J.M., England D.M.,
RA Klein M.H.;
RL Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-
CC diacyl-sn-glycerol + diphosphate; Xref=Rhea:RHEA:16229,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563,
CC ChEBI:CHEBI:58332, ChEBI:CHEBI:58608; EC=2.7.7.41;
CC -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-
CC diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CDS family. {ECO:0000305}.
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DR EMBL; L42023; AAC22577.1; -; Genomic_DNA.
DR EMBL; U60831; AAB61967.1; -; Genomic_DNA.
DR EMBL; U60832; AAB61972.1; -; Genomic_DNA.
DR PIR; G64102; G64102.
DR RefSeq; NP_439079.1; NC_000907.1.
DR RefSeq; WP_005693266.1; NC_000907.1.
DR AlphaFoldDB; P44937; -.
DR SMR; P44937; -.
DR STRING; 71421.HI_0919; -.
DR EnsemblBacteria; AAC22577; AAC22577; HI_0919.
DR KEGG; hin:HI_0919; -.
DR PATRIC; fig|71421.8.peg.960; -.
DR eggNOG; COG0575; Bacteria.
DR HOGENOM; CLU_037294_1_2_6; -.
DR OMA; WEWGRLN; -.
DR PhylomeDB; P44937; -.
DR BioCyc; HINF71421:G1GJ1-958-MON; -.
DR UniPathway; UPA00557; UER00614.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004605; F:phosphatidate cytidylyltransferase activity; IBA:GO_Central.
DR GO; GO:0016024; P:CDP-diacylglycerol biosynthetic process; IBA:GO_Central.
DR InterPro; IPR000374; PC_trans.
DR PROSITE; PS01315; CDS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Lipid biosynthesis; Lipid metabolism;
KW Membrane; Nucleotidyltransferase; Phospholipid biosynthesis;
KW Phospholipid metabolism; Reference proteome; Transferase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..288
FT /note="Phosphatidate cytidylyltransferase"
FT /id="PRO_0000090736"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..243
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 16
FT /note="V -> F (in strain: Eagan)"
FT VARIANT 59
FT /note="T -> A (in strain: 33)"
FT VARIANT 81
FT /note="R -> H (in strain: Eagan)"
SQ SEQUENCE 288 AA; 32247 MW; 67FFBF29997FAFA5 CRC64;
MLKQRVLSAI VLIAAVLCAL FLFTPFYFAL ALGAVAILGI WEWTQFARLK QPLIRFFVTT
FLGVFIFLWL YTEGNYLDAG RVFEQHLQLL LINAVSWWGL ALLLVISYPK SAKFWSKNPL
LQLLFAFSTL IPFVAGVLRL RLEHYTHDPY HGLFLLLYVF ILVWAADSGA YFSGRAFGKR
KLAPKVSPGK SWEGVIGGLI TALVLAFIFI HFSNNTLVGD RNITGFIILS VATVAISVLG
DLTESMFKRE SGVKDSSQLI PGHGGVLDRI DSLTAAVPFF SYFYFFVL
