CDSA_PSEAE
ID CDSA_PSEAE Reviewed; 271 AA.
AC Q59640;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 08-DEC-2000, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Phosphatidate cytidylyltransferase;
DE EC=2.7.7.41;
DE AltName: Full=CDP-DAG synthase;
DE AltName: Full=CDP-DG synthase;
DE AltName: Full=CDP-diacylglycerol synthase;
DE Short=CDS;
DE AltName: Full=CDP-diglyceride pyrophosphorylase;
DE AltName: Full=CDP-diglyceride synthase;
DE AltName: Full=CTP:phosphatidate cytidylyltransferase;
GN Name=cdsA; Synonyms=cds; OrderedLocusNames=PA3651;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=8654980; DOI=10.1016/0378-1119(96)00009-1;
RA Taguchi K., Fukutomi H., Kuroda A., Kato J., Ohtake H.;
RT "Cloning of the Pseudomonas aeruginosa gene encoding CDP-diglyceride
RT synthetase.";
RL Gene 172:165-166(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-
CC diacyl-sn-glycerol + diphosphate; Xref=Rhea:RHEA:16229,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563,
CC ChEBI:CHEBI:58332, ChEBI:CHEBI:58608; EC=2.7.7.41;
CC -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-
CC diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the CDS family. {ECO:0000305}.
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DR EMBL; D50811; BAA09437.1; -; Genomic_DNA.
DR EMBL; AE004091; AAG07039.1; -; Genomic_DNA.
DR PIR; F83188; F83188.
DR PIR; JC4832; JC4832.
DR RefSeq; NP_252341.1; NC_002516.2.
DR RefSeq; WP_003092388.1; NZ_QZGE01000001.1.
DR AlphaFoldDB; Q59640; -.
DR SMR; Q59640; -.
DR STRING; 287.DR97_4288; -.
DR PaxDb; Q59640; -.
DR PRIDE; Q59640; -.
DR DNASU; 880465; -.
DR EnsemblBacteria; AAG07039; AAG07039; PA3651.
DR GeneID; 880465; -.
DR KEGG; pae:PA3651; -.
DR PATRIC; fig|208964.12.peg.3820; -.
DR PseudoCAP; PA3651; -.
DR HOGENOM; CLU_037294_1_2_6; -.
DR InParanoid; Q59640; -.
DR OMA; WEWGRLN; -.
DR PhylomeDB; Q59640; -.
DR BioCyc; PAER208964:G1FZ6-3721-MON; -.
DR UniPathway; UPA00557; UER00614.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004605; F:phosphatidate cytidylyltransferase activity; IBA:GO_Central.
DR GO; GO:0016024; P:CDP-diacylglycerol biosynthetic process; IBA:GO_Central.
DR InterPro; IPR000374; PC_trans.
DR PROSITE; PS01315; CDS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Lipid biosynthesis; Lipid metabolism;
KW Membrane; Nucleotidyltransferase; Phospholipid biosynthesis;
KW Phospholipid metabolism; Reference proteome; Transferase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..271
FT /note="Phosphatidate cytidylyltransferase"
FT /id="PRO_0000090744"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 131..133
FT /note="WPL -> VAA (in Ref. 1; BAA09437)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 271 AA; 28856 MW; 5025059C3F1A64C7 CRC64;
MLKQRIITAL VLLPIALGGF FLLEGAFFAL FIGAVVSLGA WEWARLAGYE QQFGRVAYAA
TVAVLMVALY HLPQLAGAVL LLALVWWTLA TVLVLTYPES VGYWGGRWRR LGMGLLILLP
AWQGLVLLKQ WPLANGLIIA VMVLVWGADI GAYFSGKAFG KRKLAPRVSP GKSWEGVYGG
LAASLAITLA VGLYRGWSLG ALLLALLGAA LVVFVSIVGD LTESMFKRQS GIKDSSNLLP
GHGGVLDRID SLTAAIPVFA ALLWAAGWGA P
