ID   CDSN_MACMU              Reviewed;         534 AA.
AC   Q5TM45;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Corneodesmosin;
DE   Flags: Precursor;
GN   Name=CDSN;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15269276; DOI=10.1093/molbev/msh216;
RA   Kulski J.K., Anzai T., Shiina T., Inoko H.;
RT   "Rhesus macaque class I duplicon structures, organization, and evolution
RT   within the alpha block of the major histocompatibility complex.";
RL   Mol. Biol. Evol. 21:2079-2091(2004).
CC   -!- FUNCTION: Important for the epidermal barrier integrity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Note=Found in corneodesmosomes, the
CC       intercellular structures that are involved in desquamation.
CC       {ECO:0000250}.
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DR   EMBL; AB128049; BAD69749.1; -; Genomic_DNA.
DR   RefSeq; NP_001098639.1; NM_001105169.1.
DR   AlphaFoldDB; Q5TM45; -.
DR   STRING; 9544.ENSMMUP00000020575; -.
DR   PRIDE; Q5TM45; -.
DR   GeneID; 714553; -.
DR   KEGG; mcc:714553; -.
DR   CTD; 1041; -.
DR   eggNOG; ENOG502SQ6F; Eukaryota.
DR   InParanoid; Q5TM45; -.
DR   OrthoDB; 1337671at2759; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042803; F:protein homodimerization activity; IBA:GO_Central.
DR   GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR   GO; GO:0043589; P:skin morphogenesis; ISS:UniProtKB.
DR   InterPro; IPR026087; Corneodesmosin.
DR   PANTHER; PTHR23207; PTHR23207; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000255"
FT   CHAIN           33..534
FT                   /note="Corneodesmosin"
FT                   /id="PRO_0000020913"
FT   REGION          38..252
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          396..497
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..227
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        396..475
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   534 AA;  51983 MW;  CB6A9DF256C32874 CRC64;
     MGLSRAPWMG RVGGRGMMAL LLAGLLLPGT LAKSIGTFSD PCKDPTRITS PNDPCLTGKG
     GSSGFSSYSG SSGSGSSISS ASGSGGGSSG SSVAQGGSAG SFKPGTGYSQ VSYSSGSGSS
     LQGASSSSQL GGSGSQPGSS GSQPGSSGSH SGSSGSNTGS SSSHSSSSST FQFSSSSSQV
     GSGSALPTSD NAYRGILNPS QLGQSSSFSQ TSGQRVSSNQ RPCSSDIPDS PCSGGPIISH
     SGPYIPSSHS VSGGQRPVVV VVEQHGSGGP GVVQGLPCSN GGLPGKPCPP ITSVDKSYGG
     YEVVGGSSDS YLVPGMTYSK GKIYPVGYFT KDNPVKGSPG VPSFAAGPPI SEGKYFSSNP
     IIPSQSGASS VIAFQPVGTG GVQLCGGGST GSKGPCSPFS SRVHSSSSIS SSSGSPYHPC
     GSTSQSPCSP PGTGSFSSSS SSQSSGKIIL QPCGSKSSSS GHPCMSVSSL TLTGDPDGSP
     HPDPSAGAKP CGSGSAGKIP CRSIRDILAQ VKPLGPQLAD PEVFLPQGEL LDSP