CDSN_MOUSE
ID CDSN_MOUSE Reviewed; 561 AA.
AC Q7TPC1; E9QLN3;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Corneodesmosin;
DE Flags: Precursor;
GN Name=Cdsn;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C3H/He; TISSUE=Osteoblast;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Important for the epidermal barrier integrity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted. Note=Found in corneodesmosomes, the
CC intercellular structures that are involved in desquamation.
CC {ECO:0000250}.
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DR EMBL; CR974473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC055373; AAH55373.1; -; mRNA.
DR CCDS; CCDS28699.1; -.
DR RefSeq; NP_001008424.2; NM_001008424.2.
DR AlphaFoldDB; Q7TPC1; -.
DR SMR; Q7TPC1; -.
DR BioGRID; 239715; 5.
DR STRING; 10090.ENSMUSP00000048596; -.
DR iPTMnet; Q7TPC1; -.
DR PhosphoSitePlus; Q7TPC1; -.
DR MaxQB; Q7TPC1; -.
DR PaxDb; Q7TPC1; -.
DR PeptideAtlas; Q7TPC1; -.
DR PRIDE; Q7TPC1; -.
DR ProteomicsDB; 281302; -.
DR Antibodypedia; 26774; 144 antibodies from 20 providers.
DR Ensembl; ENSMUST00000044804; ENSMUSP00000048596; ENSMUSG00000039518.
DR GeneID; 386463; -.
DR KEGG; mmu:386463; -.
DR UCSC; uc008cia.1; mouse.
DR CTD; 1041; -.
DR MGI; MGI:3505689; Cdsn.
DR VEuPathDB; HostDB:ENSMUSG00000039518; -.
DR eggNOG; ENOG502SQ6F; Eukaryota.
DR GeneTree; ENSGT00730000111474; -.
DR HOGENOM; CLU_039631_0_0_1; -.
DR InParanoid; Q7TPC1; -.
DR OMA; HSGPYIS; -.
DR OrthoDB; 1337671at2759; -.
DR PhylomeDB; Q7TPC1; -.
DR Reactome; R-MMU-6809371; Formation of the cornified envelope.
DR BioGRID-ORCS; 386463; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Cdsn; mouse.
DR PRO; PR:Q7TPC1; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q7TPC1; protein.
DR Bgee; ENSMUSG00000039518; Expressed in lip and 56 other tissues.
DR Genevisible; Q7TPC1; MM.
DR GO; GO:0030057; C:desmosome; ISO:MGI.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042803; F:protein homodimerization activity; IBA:GO_Central.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0003336; P:corneocyte desquamation; ISO:MGI.
DR GO; GO:1905716; P:negative regulation of cornification; ISO:MGI.
DR GO; GO:0043589; P:skin morphogenesis; ISS:UniProtKB.
DR InterPro; IPR026087; Corneodesmosin.
DR PANTHER; PTHR23207; PTHR23207; 2.
PE 2: Evidence at transcript level;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..561
FT /note="Corneodesmosin"
FT /id="PRO_0000020914"
FT REGION 41..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 536..561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 5
FT /note="R -> Q (in Ref. 2; AAH55373)"
FT /evidence="ECO:0000305"
FT CONFLICT 129
FT /note="S -> T (in Ref. 2; AAH55373)"
FT /evidence="ECO:0000305"
FT CONFLICT 133
FT /note="G -> S (in Ref. 2; AAH55373)"
FT /evidence="ECO:0000305"
FT CONFLICT 136
FT /note="S -> T (in Ref. 2; AAH55373)"
FT /evidence="ECO:0000305"
FT CONFLICT 140
FT /note="G -> S (in Ref. 2; AAH55373)"
FT /evidence="ECO:0000305"
FT CONFLICT 287
FT /note="Q -> H (in Ref. 2; AAH55373)"
FT /evidence="ECO:0000305"
FT CONFLICT 291
FT /note="G -> A (in Ref. 2; AAH55373)"
FT /evidence="ECO:0000305"
FT CONFLICT 400
FT /note="A -> V (in Ref. 2; AAH55373)"
FT /evidence="ECO:0000305"
FT CONFLICT 446
FT /note="P -> S (in Ref. 2; AAH55373)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 561 AA; 54313 MW; D48586A99DA2A1E7 CRC64;
MGSSRAPRMG SVGGHGLMAL LMAGLILPGI LAKSIGTLSD PCKDPTRITS PNDPCLIGKT
GSNSISSQGG SSSFSSQGGS SSFSSHGGSS SSQGSSSGSL IYKPGTGYSQ SSYSYGSGGS
RPGGSGSQSG SSGSQSGSSG SQSGSSGSQS GSSGSQSGSS GSQSGSSGSQ SGSSGSQSGS
SGSQSGRWVS SSSQWVSSSS QSGSSGSSRD RPGSGSALPT GDKTSGMSQS GGSSTSQSSS
SNLRPCSSNV PDSPCSGGPV ITHSGPYISG THTVSGGQRP VVVVVEQHGS GGPGFQGMPC
SNGGPAGKPC PPITSVQKPY GGYEVVGGSA NSYLVPGMTY SGGKIYPVGY FTKDNPIRGS
PGAPSFAAGP PVSEGKYFSS NPIIPSRGSS SSSGYPVGVA FQPVGSGGVQ PCGTGSVSSK
GPCSGTRIQI TSSSSSTSYH PCSGGPSQGP CSSPGTGSIS GGSSSLSSGK IVLQPCGSKS
TSSGYPCLSV PSSPLNGGLN GSPQPVPSVG VKLCGLNSPG RVPCRSIRNI LTQVKPLGPQ
LMDPKVSLPQ GEPQGEPLEK S
