ID   CDSN_PIG                Reviewed;         225 AA.
AC   O19084;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Corneodesmosin;
DE   AltName: Full=S protein;
DE   Flags: Fragment;
GN   Name=CDSN;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Peripheral blood;
RA   Velten F.W., Rogel-Gaillard C., Renard C., Pontarotti P., Tazi-Ahnini R.,
RA   Vaiman M., Chardon P.;
RL   Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Important for the epidermal barrier integrity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Note=Found in corneodesmosomes, the
CC       intercellular structures that are involved in desquamation.
CC       {ECO:0000250}.
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DR   EMBL; Z97402; CAB10690.1; -; Genomic_DNA.
DR   AlphaFoldDB; O19084; -.
DR   InParanoid; O19084; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042803; F:protein homodimerization activity; IBA:GO_Central.
DR   GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR   GO; GO:0043589; P:skin morphogenesis; ISS:UniProtKB.
DR   InterPro; IPR026087; Corneodesmosin.
DR   PANTHER; PTHR23207; PTHR23207; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Secreted.
FT   CHAIN           <1..>225
FT                   /note="Corneodesmosin"
FT                   /id="PRO_0000089458"
FT   REGION          140..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        140..202
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT   NON_TER         225
SQ   SEQUENCE   225 AA;  21644 MW;  8544070C41F7B280 CRC64;
     GKPCPPITSV DKFGSYEVVG GSSDSYLVPG MTYSGGKIYP VGYFTKDNPV KGSPGAPSFA
     AGPPISEGKY FSSNPIIPSH SSSSSNIYQS GASSAIVFQP VGSGGVQPCG VGSSGSKGPC
     SLSGSGVHSS SSISSSSGSS FHPCGTVSQG PCSPPGTGSF SGSSSSKSGG KIILQPCGSK
     SSSSGHPCIS VSSSTLSGGP DGSPQPDPSA GAKPCGSGSS GKIPC