CDT1B_ARATH
ID CDT1B_ARATH Reviewed; 486 AA.
AC Q9M1S9;
DT 05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=CDT1-like protein b;
DE Short=AtCDT1b;
GN Name=CDT1B; OrderedLocusNames=At3g54710; ORFNames=T5N23.70;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia;
RX PubMed=15316110; DOI=10.1105/tpc.104.022400;
RA del Mar Castellano M., Boniotti M.B., Caro E., Schnittger A., Gutierrez C.;
RT "DNA replication licensing affects cell proliferation or endoreplication in
RT a cell type-specific manner.";
RL Plant Cell 16:2380-2393(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Bautista V.R., Kim C.J., Chen H., Quinitio C., Ecker J.R.;
RT "Arabidopsis ORF Clone.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION.
RC STRAIN=cv. Wassilewskija;
RX PubMed=15928083; DOI=10.1073/pnas.0502564102;
RA Raynaud C., Perennes C., Reuzeau C., Catrice O., Brown S., Bergounioux C.;
RT "Cell and plastid division are coordinated through the prereplication
RT factor AtCDT1.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:8216-8221(2005).
RN [6]
RP INDUCTION BY ABAP1.
RX PubMed=18818695; DOI=10.1038/emboj.2008.191;
RA Masuda H.P., Cabral L.M., De Veylder L., Tanurdzic M.,
RA de Almeida Engler J., Geelen D., Inze D., Martienssen R.A., Ferreira P.C.,
RA Hemerly A.S.;
RT "ABAP1 is a novel plant Armadillo BTB protein involved in DNA replication
RT and transcription.";
RL EMBO J. 27:2746-2756(2008).
CC -!- FUNCTION: Member of the pre-replication complex. Regulates
CC endoreduplication. Involved in the coordination of cell and plastid
CC division. {ECO:0000269|PubMed:15928083}.
CC -!- INTERACTION:
CC Q9M1S9; B7U179: ABAP1; NbExp=2; IntAct=EBI-8079764, EBI-541722;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in proliferating (e.g. shoot and root
CC apical meristems, organ primordia, guard cells and stomatal lineage)
CC and endoreplicating cells (e.g. developing trichomes).
CC {ECO:0000269|PubMed:15316110}.
CC -!- INDUCTION: Repressed by ABAP1. {ECO:0000269|PubMed:18818695}.
CC -!- SIMILARITY: Belongs to the Cdt1 family. {ECO:0000305}.
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DR EMBL; AJ421409; CAD13173.1; -; mRNA.
DR EMBL; AL138650; CAB77591.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE79269.1; -; Genomic_DNA.
DR EMBL; BT029185; ABJ17120.1; -; mRNA.
DR PIR; T47630; T47630.
DR RefSeq; NP_191031.1; NM_115328.4.
DR AlphaFoldDB; Q9M1S9; -.
DR SMR; Q9M1S9; -.
DR BioGRID; 9952; 2.
DR IntAct; Q9M1S9; 2.
DR MINT; Q9M1S9; -.
DR STRING; 3702.AT3G54710.1; -.
DR iPTMnet; Q9M1S9; -.
DR PaxDb; Q9M1S9; -.
DR PRIDE; Q9M1S9; -.
DR ProteomicsDB; 220524; -.
DR EnsemblPlants; AT3G54710.1; AT3G54710.1; AT3G54710.
DR GeneID; 824636; -.
DR Gramene; AT3G54710.1; AT3G54710.1; AT3G54710.
DR KEGG; ath:AT3G54710; -.
DR Araport; AT3G54710; -.
DR TAIR; locus:2102460; AT3G54710.
DR eggNOG; KOG4762; Eukaryota.
DR HOGENOM; CLU_019037_1_0_1; -.
DR InParanoid; Q9M1S9; -.
DR OMA; DTICGTK; -.
DR OrthoDB; 648388at2759; -.
DR PhylomeDB; Q9M1S9; -.
DR PRO; PR:Q9M1S9; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9M1S9; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; ISS:TAIR.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0070182; F:DNA polymerase binding; IPI:TAIR.
DR GO; GO:0009658; P:chloroplast organization; IMP:TAIR.
DR GO; GO:0051276; P:chromosome organization; IMP:TAIR.
DR GO; GO:0006260; P:DNA replication; IMP:TAIR.
DR GO; GO:0000076; P:DNA replication checkpoint signaling; IBA:GO_Central.
DR GO; GO:0071163; P:DNA replication preinitiation complex assembly; IBA:GO_Central.
DR GO; GO:0048229; P:gametophyte development; IMP:TAIR.
DR GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0030174; P:regulation of DNA-templated DNA replication initiation; IBA:GO_Central.
DR CDD; cd08767; Cdt1_c; 1.
DR CDD; cd08674; Cdt1_m; 1.
DR Gene3D; 1.10.10.1420; -; 1.
DR InterPro; IPR045173; Cdt1.
DR InterPro; IPR032054; Cdt1_C.
DR InterPro; IPR038090; Cdt1_C_WH_dom_sf.
DR InterPro; IPR014939; CDT1_Gemini-bd-like.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR28637; PTHR28637; 1.
DR Pfam; PF08839; CDT1; 1.
DR Pfam; PF16679; CDT1_C; 1.
DR SMART; SM01075; CDT1; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
PE 1: Evidence at protein level;
KW Cell cycle; DNA replication; Nucleus; Reference proteome.
FT CHAIN 1..486
FT /note="CDT1-like protein b"
FT /id="PRO_0000406939"
FT REGION 273..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 348..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..367
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 486 AA; 55019 MW; B0289B35659F145E CRC64;
MSSSSKIDSE KPVMVSESLF STKTPIKTVK RQIFSSSPKP ESVIKLPERF EILEEFFNGL
DTAIRLLKLK GSSTTYANIC PKIEYLTNRI FSYDHLAQMK HIYPEAIELK RVLKFVEDTC
CMKPRLHIKL NTDAIVVEDT ICGTKYMELR KVFHSKLVDF RKAHPKDEIP KELLPEPFNS
PQRDSYSGIV SVGLGEPKLE VGGFDVHMEE IEQEEQDVNK VIPDSTLSHI ESRIVETPVK
DLSTPSKDLS TPIRLMSATP TLQLSKRCIE LTPEGGDDNS LRSTNSLARG PSRSLNFDTF
EEDAIEKDDI GNESDDKGIN YEEDGLLQSV KGPSRSLNFD TLEEETIVKD DISNESGDEK
SNYEGDNASD DDSLLQSMIE RPKTEPEKHN LPQLVNLIHR VFHSTNRTVI TKEELLYKII
ANQINITDRR EVEEQLSLML QLVPDWISET KASSGDLLVR INKMSTAETV RARLEEATSH
DISLIY
