ID   CDT1_ECHCC              Reviewed;          55 AA.
AC   B5BSU1;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   03-AUG-2022, entry version 22.
DE   RecName: Full=Protein CADMIUM TOLERANCE 1 {ECO:0000303|PubMed:19816106};
DE            Short=Cd tolerant 1 {ECO:0000303|PubMed:19816106};
DE            Short=EcCDT1 {ECO:0000303|PubMed:19816106};
GN   Name=CDT1 {ECO:0000303|PubMed:19816106};
OS   Echinochloa crus-galli subsp. caudata (Cockspur) (Echinochloa caudata).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Panicodae; Paniceae; Boivinellinae; Echinochloa.
OX   NCBI_TaxID=227868;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=19017626; DOI=10.1093/pcp/pcn175;
RA   Kuramata M., Masuya S., Takahashi Y., Kitagawa E., Inoue C., Ishikawa S.,
RA   Youssefian S., Kusano T.;
RT   "Novel cysteine-rich peptides from Digitaria ciliaris and Oryza sativa
RT   enhance tolerance to cadmium by limiting its cellular accumulation.";
RL   Plant Cell Physiol. 50:106-117(2009).
RN   [2]
RP   GENE FAMILY.
RX   PubMed=19816106; DOI=10.4161/psb.4.5.8272;
RA   Matsuda T., Kuramata M., Takahashi Y., Kitagawa E., Youssefian S.,
RA   Kusano T.;
RT   "A novel plant cysteine-rich peptide family conferring cadmium tolerance to
RT   yeast and plants.";
RL   Plant Signal. Behav. 4:419-421(2009).
CC   -!- FUNCTION: Confers resistance to heavy metal ions (e.g. cadmium
CC       (CdCl(2)) and copper (CuCl(2))) by chelating them at the plasma
CC       membrane of root cells, thus stopping their entry and reducing their
CC       accumulation. {ECO:0000250|UniProtKB:A9ZPI1}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:A9ZPI1};
CC       Single-pass membrane protein {ECO:0000255}. Secreted, cell wall
CC       {ECO:0000250|UniProtKB:A9ZPI1}.
CC   -!- SIMILARITY: Belongs to the CYSTM1 family. {ECO:0000305}.
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DR   EMBL; AB426477; BAG70355.1; -; mRNA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009505; C:plant-type cell wall; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; ISS:UniProtKB.
DR   GO; GO:0140487; F:metal ion sequestering activity; ISS:UniProtKB.
DR   GO; GO:1990748; P:cellular detoxification; ISS:UniProtKB.
DR   GO; GO:0071585; P:detoxification of cadmium ion; ISS:UniProtKB.
DR   GO; GO:0010273; P:detoxification of copper ion; ISS:UniProtKB.
DR   InterPro; IPR028144; CYSTM_dom.
DR   Pfam; PF12734; CYSTM; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Cell wall; Membrane; Metal-binding; Secreted;
KW   Stress response; Transmembrane; Transmembrane helix.
FT   CHAIN           1..55
FT                   /note="Protein CADMIUM TOLERANCE 1"
FT                   /id="PRO_0000454811"
FT   TRANSMEM        24..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   55 AA;  6415 MW;  B2D382056E664BC2 CRC64;
     MYNAPPPQDM SYYDHCQRRH EEKGCLYACI FTALCCFCCY ETCECCLDCL CCCCN