ID   CDT1_ORYSI              Reviewed;          55 AA.
AC   B8B2D0;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   23-FEB-2022, sequence version 2.
DT   03-AUG-2022, entry version 35.
DE   RecName: Full=Protein CADMIUM TOLERANCE 1 {ECO:0000305};
DE            Short=Cd tolerant 1 {ECO:0000305};
DE            Short=OsCDT1 {ECO:0000305};
GN   Name=CDT1 {ECO:0000305}; ORFNames=OsI_21594 {ECO:0000312|EMBL:EEC79970.1};
OS   Oryza sativa subsp. indica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39946;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. 93-11;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
CC   -!- FUNCTION: Confers resistance to heavy metal ions (e.g. cadmium
CC       (CdCl(2)) and copper (CuCl(2))) by chelating them at the plasma
CC       membrane of root cells, thus stopping their entry and reducing their
CC       accumulation (By similarity). Binds to aluminium (Al) (By similarity).
CC       {ECO:0000250|UniProtKB:Q5VSB5}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5VSB5};
CC       Single-pass membrane protein {ECO:0000255}. Secreted, cell wall
CC       {ECO:0000250|UniProtKB:Q5VSB5}.
CC   -!- SIMILARITY: Belongs to the CYSTM1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EEC79970.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; CM000131; EEC79970.1; ALT_INIT; Genomic_DNA.
DR   EnsemblPlants; BGIOSGA021949-TA; BGIOSGA021949-PA; BGIOSGA021949.
DR   Gramene; BGIOSGA021949-TA; BGIOSGA021949-PA; BGIOSGA021949.
DR   HOGENOM; CLU_156676_2_0_1; -.
DR   OMA; THHRIQH; -.
DR   Proteomes; UP000007015; Chromosome 6.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009505; C:plant-type cell wall; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; ISS:UniProtKB.
DR   GO; GO:0140487; F:metal ion sequestering activity; ISS:UniProtKB.
DR   GO; GO:1990748; P:cellular detoxification; ISS:UniProtKB.
DR   GO; GO:0071585; P:detoxification of cadmium ion; ISS:UniProtKB.
DR   GO; GO:0010273; P:detoxification of copper ion; ISS:UniProtKB.
DR   InterPro; IPR028144; CYSTM_dom.
DR   Pfam; PF12734; CYSTM; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Cell wall; Membrane; Metal-binding; Reference proteome;
KW   Secreted; Stress response; Transmembrane; Transmembrane helix.
FT   CHAIN           1..55
FT                   /note="Protein CADMIUM TOLERANCE 1"
FT                   /id="PRO_0000454814"
FT   TRANSMEM        24..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   55 AA;  6448 MW;  3401593072564A8E CRC64;
     MYNAPMAQEM SYYEHVQRRH EEKGCLYACI FTALCCFCCY ETCECCLDCL CCCCN