CDT1_ORYSJ
ID CDT1_ORYSJ Reviewed; 55 AA.
AC Q5VSB5; A0A0P0WSX6; B9FRF8;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Protein CADMIUM TOLERANCE 1 {ECO:0000303|PubMed:19017626};
DE Short=Cd tolerant 1 {ECO:0000303|PubMed:19017626};
DE Short=OsCDT1 {ECO:0000303|PubMed:19017626};
GN Name=CDT1 {ECO:0000303|PubMed:19017626};
GN OrderedLocusNames=Os06g0143100 {ECO:0000312|EMBL:BAS96111.1};
GN ORFNames=OsJ_20092 {ECO:0000312|EMBL:EEE65069.1},
GN OSNPB_060143100 {ECO:0000312|EMBL:BAS96111.1},
GN P0535G04.32-2 {ECO:0000312|EMBL:BAD67660.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [6]
RP FUNCTION, TISSUE SPECIFICITY, INDUCTION BY CADMIUM, SUBCELLULAR LOCATION,
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19017626; DOI=10.1093/pcp/pcn175;
RA Kuramata M., Masuya S., Takahashi Y., Kitagawa E., Inoue C., Ishikawa S.,
RA Youssefian S., Kusano T.;
RT "Novel cysteine-rich peptides from Digitaria ciliaris and Oryza sativa
RT enhance tolerance to cadmium by limiting its cellular accumulation.";
RL Plant Cell Physiol. 50:106-117(2009).
RN [7]
RP FUNCTION, AND GENE FAMILY.
RX PubMed=19816106; DOI=10.4161/psb.4.5.8272;
RA Matsuda T., Kuramata M., Takahashi Y., Kitagawa E., Youssefian S.,
RA Kusano T.;
RT "A novel plant cysteine-rich peptide family conferring cadmium tolerance to
RT yeast and plants.";
RL Plant Signal. Behav. 4:419-421(2009).
RN [8]
RP FUNCTION.
RC STRAIN=cv. Nipponbare;
RX PubMed=23888867; DOI=10.1111/tpj.12296;
RA Xia J., Yamaji N., Ma J.F.;
RT "A plasma membrane-localized small peptide is involved in rice aluminium
RT tolerance.";
RL Plant J. 76:345-355(2013).
CC -!- FUNCTION: Confers resistance to heavy metal ions (e.g. cadmium
CC (CdCl(2)) and copper (CuCl(2))) by chelating them at the plasma
CC membrane of root cells, thus stopping their entry and reducing their
CC accumulation (PubMed:19017626, PubMed:19816106). Binds to aluminium
CC (Al) (PubMed:23888867). {ECO:0000269|PubMed:19017626,
CC ECO:0000269|PubMed:19816106, ECO:0000269|PubMed:23888867}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19017626};
CC Single-pass membrane protein {ECO:0000255}. Secreted, cell wall
CC {ECO:0000269|PubMed:19017626}.
CC -!- TISSUE SPECIFICITY: Expressed in roots and shoots.
CC {ECO:0000269|PubMed:19017626}.
CC -!- INDUCTION: Down-regulated in root tissues but up-regulated in shoot
CC tissues in response to cadmium (CdCl(2)).
CC {ECO:0000269|PubMed:19017626}.
CC -!- SIMILARITY: Belongs to the CYSTM1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EEE65069.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AP000399; BAD67660.1; -; Genomic_DNA.
DR EMBL; AP014962; BAS96111.1; -; Genomic_DNA.
DR EMBL; CM000143; EEE65069.1; ALT_INIT; Genomic_DNA.
DR EMBL; AK121057; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; Q5VSB5; -.
DR STRING; 4530.OS06T0143100-02; -.
DR PRIDE; Q5VSB5; -.
DR EnsemblPlants; Os06t0143100-02; Os06t0143100-02; Os06g0143100.
DR Gramene; Os06t0143100-02; Os06t0143100-02; Os06g0143100.
DR eggNOG; ENOG502S75V; Eukaryota.
DR HOGENOM; CLU_156676_2_0_1; -.
DR InParanoid; Q5VSB5; -.
DR Proteomes; UP000000763; Chromosome 6.
DR Proteomes; UP000007752; Chromosome 6.
DR Proteomes; UP000059680; Chromosome 6.
DR ExpressionAtlas; Q5VSB5; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009505; C:plant-type cell wall; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IDA:UniProtKB.
DR GO; GO:0140487; F:metal ion sequestering activity; ISS:UniProtKB.
DR GO; GO:1990748; P:cellular detoxification; ISS:UniProtKB.
DR GO; GO:0071585; P:detoxification of cadmium ion; IDA:UniProtKB.
DR GO; GO:0010273; P:detoxification of copper ion; IDA:UniProtKB.
DR GO; GO:0046686; P:response to cadmium ion; IEP:UniProtKB.
DR InterPro; IPR028144; CYSTM_dom.
DR Pfam; PF12734; CYSTM; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cell wall; Membrane; Metal-binding; Reference proteome;
KW Secreted; Stress response; Transmembrane; Transmembrane helix.
FT CHAIN 1..55
FT /note="Protein CADMIUM TOLERANCE 1"
FT /id="PRO_0000454813"
FT TRANSMEM 24..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 15
FT /note="H -> Y (in Ref. 5; AK121057)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 55 AA; 6434 MW; 5F6D293072564BDF CRC64;
MYNAPMAQDM SYYEHVQRRH EEKGCLYACI FTALCCFCCY ETCECCLDCL CCCCN
