ID   CDT2_ORYSJ              Reviewed;          55 AA.
AC   Q5VSB6; A0A0P0WSC5;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Protein CADMIUM TOLERANCE 2 {ECO:0000303|PubMed:19017626};
DE            Short=Cd tolerant 2 {ECO:0000303|PubMed:19017626};
DE            Short=OsCDT2 {ECO:0000303|PubMed:19017626};
GN   Name=CDT2 {ECO:0000303|PubMed:19017626};
GN   OrderedLocusNames=Os06g0143100 {ECO:0000312|EMBL:BAS96110.1};
GN   ORFNames=OSNPB_060143100 {ECO:0000312|EMBL:BAS96110.1},
GN   P0535G04.32-1 {ECO:0000312|EMBL:BAD67659.1};
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [5]
RP   TISSUE SPECIFICITY, INDUCTION BY CADMIUM, GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=19017626; DOI=10.1093/pcp/pcn175;
RA   Kuramata M., Masuya S., Takahashi Y., Kitagawa E., Inoue C., Ishikawa S.,
RA   Youssefian S., Kusano T.;
RT   "Novel cysteine-rich peptides from Digitaria ciliaris and Oryza sativa
RT   enhance tolerance to cadmium by limiting its cellular accumulation.";
RL   Plant Cell Physiol. 50:106-117(2009).
RN   [6]
RP   GENE FAMILY.
RX   PubMed=19816106; DOI=10.4161/psb.4.5.8272;
RA   Matsuda T., Kuramata M., Takahashi Y., Kitagawa E., Youssefian S.,
RA   Kusano T.;
RT   "A novel plant cysteine-rich peptide family conferring cadmium tolerance to
RT   yeast and plants.";
RL   Plant Signal. Behav. 4:419-421(2009).
CC   -!- FUNCTION: Confers resistance to heavy metal ions (e.g. cadmium
CC       (CdCl(2)) and copper (CuCl(2))) by chelating them at the plasma
CC       membrane of root cells, thus stopping their entry and reducing their
CC       accumulation. {ECO:0000250|UniProtKB:Q5VSB5}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5VSB5};
CC       Single-pass membrane protein {ECO:0000255}. Secreted, cell wall
CC       {ECO:0000250|UniProtKB:Q5VSB5}.
CC   -!- TISSUE SPECIFICITY: Expressed only in roots.
CC       {ECO:0000269|PubMed:19017626}.
CC   -!- INDUCTION: Down-regulated in root tissues but up-regulated in shoot
CC       tissues in response to cadmium (CdCl(2)).
CC       {ECO:0000269|PubMed:19017626}.
CC   -!- SIMILARITY: Belongs to the CYSTM1 family. {ECO:0000305}.
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DR   EMBL; AP000399; BAD67659.1; -; Genomic_DNA.
DR   EMBL; AP008212; BAH93323.1; -; Genomic_DNA.
DR   EMBL; AP014962; BAS96110.1; -; Genomic_DNA.
DR   EMBL; AK061597; BAG88031.1; -; mRNA.
DR   PaxDb; Q5VSB6; -.
DR   PRIDE; Q5VSB6; -.
DR   EnsemblPlants; Os06t0143100-01; Os06t0143100-01; Os06g0143100.
DR   Gramene; Os06t0143100-01; Os06t0143100-01; Os06g0143100.
DR   InParanoid; Q5VSB6; -.
DR   OMA; THHRIQH; -.
DR   Proteomes; UP000000763; Chromosome 6.
DR   Proteomes; UP000059680; Chromosome 6.
DR   ExpressionAtlas; Q5VSB6; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009505; C:plant-type cell wall; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; ISS:UniProtKB.
DR   GO; GO:0140487; F:metal ion sequestering activity; ISS:UniProtKB.
DR   GO; GO:1990748; P:cellular detoxification; ISS:UniProtKB.
DR   GO; GO:0071585; P:detoxification of cadmium ion; ISS:UniProtKB.
DR   GO; GO:0010273; P:detoxification of copper ion; ISS:UniProtKB.
DR   GO; GO:0046686; P:response to cadmium ion; IEP:UniProtKB.
DR   InterPro; IPR028144; CYSTM_dom.
DR   Pfam; PF12734; CYSTM; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell wall; Membrane; Metal-binding; Reference proteome;
KW   Secreted; Stress response; Transmembrane; Transmembrane helix.
FT   CHAIN           1..55
FT                   /note="Protein CADMIUM TOLERANCE 2"
FT                   /id="PRO_0000454815"
FT   TRANSMEM        24..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   55 AA;  6391 MW;  DF49F2191E6DA5D1 CRC64;
     MYNPPAQQDM SYYDHCTKRH EEKGCLYACI FTALCCFCCY ETCECCLDCL CCCCN