ID   CDT3_ORYSI              Reviewed;          53 AA.
AC   A2WLC1;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Protein CADMIUM TOLERANCE 3 {ECO:0000305};
DE            Short=Cd tolerant 3 {ECO:0000305};
DE            Short=OsCDT3 {ECO:0000305};
GN   Name=CDT3 {ECO:0000305}; ORFNames=OsI_00632 {ECO:0000312|EMBL:EAY72767.1};
OS   Oryza sativa subsp. indica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39946;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. 93-11;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
CC   -!- FUNCTION: Confers resistance to heavy metal ions (e.g. aluminium) by
CC       chelating them at the plasma membrane of root cells, thus stopping
CC       their entry and reducing their accumulation (By similarity). Binds to
CC       and confers tolerance to aluminium (Al) (By similarity).
CC       {ECO:0000250|UniProtKB:Q5VRD7}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5VRD7};
CC       Single-pass membrane protein {ECO:0000250|UniProtKB:Q5VRD7}.
CC   -!- SIMILARITY: Belongs to the CYSTM1 family. {ECO:0000305}.
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DR   EMBL; CM000126; EAY72767.1; -; Genomic_DNA.
DR   STRING; 39946.A2WLC1; -.
DR   EnsemblPlants; BGIOSGA002264-TA; BGIOSGA002264-PA; BGIOSGA002264.
DR   Gramene; BGIOSGA002264-TA; BGIOSGA002264-PA; BGIOSGA002264.
DR   HOGENOM; CLU_156676_2_0_1; -.
DR   OMA; AMYNPPA; -.
DR   Proteomes; UP000007015; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009505; C:plant-type cell wall; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; ISS:UniProtKB.
DR   GO; GO:0140487; F:metal ion sequestering activity; ISS:UniProtKB.
DR   GO; GO:0055079; P:aluminum ion homeostasis; ISS:UniProtKB.
DR   GO; GO:1990748; P:cellular detoxification; ISS:UniProtKB.
DR   GO; GO:0071585; P:detoxification of cadmium ion; ISS:UniProtKB.
DR   GO; GO:0010273; P:detoxification of copper ion; ISS:UniProtKB.
DR   GO; GO:0010044; P:response to aluminum ion; ISS:UniProtKB.
DR   GO; GO:0046686; P:response to cadmium ion; IEP:UniProtKB.
DR   InterPro; IPR028144; CYSTM_dom.
DR   Pfam; PF12734; CYSTM; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Metal-binding; Reference proteome;
KW   Stress response; Transmembrane; Transmembrane helix.
FT   CHAIN           1..53
FT                   /note="Protein CADMIUM TOLERANCE 3"
FT                   /id="PRO_0000454817"
FT   TRANSMEM        24..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   53 AA;  6110 MW;  76B90CE464999625 CRC64;
     MYNPPAAQEM SYSDHVKKRH EDKGCLYACL FTLCCCFCCY ETCECCLECL CCC