CDT3_ORYSJ
ID CDT3_ORYSJ Reviewed; 53 AA.
AC Q5VRD7; Q5VRU4;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Protein CADMIUM TOLERANCE 3 {ECO:0000303|PubMed:19017626, ECO:0000303|PubMed:23888867};
DE Short=Cd tolerant 3 {ECO:0000303|PubMed:19017626, ECO:0000303|PubMed:23888867};
DE Short=OsCDT3 {ECO:0000303|PubMed:19017626, ECO:0000303|PubMed:23888867};
GN Name=CDT3 {ECO:0000303|PubMed:19017626, ECO:0000303|PubMed:23888867};
GN OrderedLocusNames=Os01g0178300 {ECO:0000312|EMBL:BAS70701.1};
GN ORFNames=OsJ_00601 {ECO:0000312|EMBL:EAZ10765.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DISRUPTION PHENOTYPE, TISSUE
RP SPECIFICITY, INDUCTION BY ALUMINIUM, AND SUBCELLULAR LOCATION.
RC STRAIN=cv. Nipponbare; TISSUE=Root;
RX PubMed=23888867; DOI=10.1111/tpj.12296;
RA Xia J., Yamaji N., Ma J.F.;
RT "A plasma membrane-localized small peptide is involved in rice aluminium
RT tolerance.";
RL Plant J. 76:345-355(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12447438; DOI=10.1038/nature01184;
RA Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y.,
RA Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H.,
RA Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.,
RA Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M.,
RA Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T.,
RA Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S.,
RA Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H.,
RA Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y.,
RA Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S.,
RA Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y.,
RA Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S.,
RA Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H.,
RA Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.;
RT "The genome sequence and structure of rice chromosome 1.";
RL Nature 420:312-316(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [6]
RP INDUCTION BY CADMIUM, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19017626; DOI=10.1093/pcp/pcn175;
RA Kuramata M., Masuya S., Takahashi Y., Kitagawa E., Inoue C., Ishikawa S.,
RA Youssefian S., Kusano T.;
RT "Novel cysteine-rich peptides from Digitaria ciliaris and Oryza sativa
RT enhance tolerance to cadmium by limiting its cellular accumulation.";
RL Plant Cell Physiol. 50:106-117(2009).
RN [7]
RP GENE FAMILY.
RX PubMed=19816106; DOI=10.4161/psb.4.5.8272;
RA Matsuda T., Kuramata M., Takahashi Y., Kitagawa E., Youssefian S.,
RA Kusano T.;
RT "A novel plant cysteine-rich peptide family conferring cadmium tolerance to
RT yeast and plants.";
RL Plant Signal. Behav. 4:419-421(2009).
CC -!- FUNCTION: Confers resistance to heavy metal ions (e.g. aluminium) by
CC chelating them at the plasma membrane of root cells, thus stopping
CC their entry and reducing their accumulation (PubMed:23888867). Binds to
CC and confers tolerance to aluminium (Al) (PubMed:23888867).
CC {ECO:0000269|PubMed:23888867}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23888867};
CC Single-pass membrane protein {ECO:0000269|PubMed:23888867}.
CC -!- TISSUE SPECIFICITY: Mostly expressed in roots at low levels and, to a
CC lower extent, in shoots (PubMed:23888867). Observed in all cell types
CC of both root tips and mature regions (at protein level)
CC (PubMed:23888867). {ECO:0000269|PubMed:23888867}.
CC -!- INDUCTION: Accumulates in roots upon aluminium (Al) exposure in an
CC STAR3/ART1-dependent manner (at protein level) (PubMed:23888867). Up-
CC regulated in shoot tissues in response to cadmium (CdCl(2))
CC (PubMed:19017626). {ECO:0000269|PubMed:19017626,
CC ECO:0000269|PubMed:23888867}.
CC -!- DISRUPTION PHENOTYPE: Decreased tolerance to aluminium (Al), but normal
CC tolerance to cadmium (Cd) (PubMed:23888867). Lower Al accumulation in
CC root cell walls and plasma membranes but increased Al levels in root
CC cell sap of plants exposed to aluminium (PubMed:23888867).
CC {ECO:0000269|PubMed:23888867}.
CC -!- SIMILARITY: Belongs to the CYSTM1 family. {ECO:0000305}.
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DR EMBL; AB787528; BAN78703.1; -; mRNA.
DR EMBL; AP014957; BAS70701.1; -; Genomic_DNA.
DR EMBL; CM000138; EAZ10765.1; -; Genomic_DNA.
DR AlphaFoldDB; Q5VRD7; -.
DR STRING; 4530.OS01T0178300-01; -.
DR PaxDb; Q5VRD7; -.
DR PRIDE; Q5VRD7; -.
DR EnsemblPlants; Os01t0178300-01; Os01t0178300-01; Os01g0178300.
DR Gramene; Os01t0178300-01; Os01t0178300-01; Os01g0178300.
DR eggNOG; ENOG502S75V; Eukaryota.
DR HOGENOM; CLU_2504494_0_0_1; -.
DR InParanoid; Q5VRD7; -.
DR PlantReactome; R-OSA-9639136; Response to Aluminum stress.
DR Proteomes; UP000007752; Chromosome 1.
DR Proteomes; UP000059680; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IDA:UniProtKB.
DR GO; GO:0140487; F:metal ion sequestering activity; IDA:UniProtKB.
DR GO; GO:0055079; P:aluminum ion homeostasis; IDA:UniProtKB.
DR GO; GO:1990748; P:cellular detoxification; IDA:UniProtKB.
DR GO; GO:0010273; P:detoxification of copper ion; ISS:UniProtKB.
DR GO; GO:0010044; P:response to aluminum ion; IDA:UniProtKB.
DR InterPro; IPR028144; CYSTM_dom.
DR Pfam; PF12734; CYSTM; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Metal-binding; Reference proteome;
KW Stress response; Transmembrane; Transmembrane helix.
FT CHAIN 1..53
FT /note="Protein CADMIUM TOLERANCE 3"
FT /id="PRO_0000454816"
FT TRANSMEM 24..40
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 53 AA; 6110 MW; 76B90CE464999625 CRC64;
MYNPPAAQEM SYSDHVKKRH EDKGCLYACL FTLCCCFCCY ETCECCLECL CCC
