CDT4_ORYSJ
ID CDT4_ORYSJ Reviewed; 60 AA.
AC A3A4E0; A0A0P0VG95; B7E3W5;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Protein CADMIUM TOLERANCE 4 {ECO:0000303|PubMed:19017626};
DE Short=Cd tolerant 4 {ECO:0000303|PubMed:19017626};
DE Short=OsCDT4 {ECO:0000303|PubMed:19017626};
GN Name=CDT4 {ECO:0000303|PubMed:19017626};
GN OrderedLocusNames=Os02g0208500 {ECO:0000312|EMBL:BAS77575.1};
GN ORFNames=OsJ_05841 {ECO:0000312|EMBL:EAZ22179.1},
GN OSNPB_020208500 {ECO:0000312|EMBL:BAS77575.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [6]
RP TISSUE SPECIFICITY, INDUCTION BY CADMIUM, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19017626; DOI=10.1093/pcp/pcn175;
RA Kuramata M., Masuya S., Takahashi Y., Kitagawa E., Inoue C., Ishikawa S.,
RA Youssefian S., Kusano T.;
RT "Novel cysteine-rich peptides from Digitaria ciliaris and Oryza sativa
RT enhance tolerance to cadmium by limiting its cellular accumulation.";
RL Plant Cell Physiol. 50:106-117(2009).
RN [7]
RP GENE FAMILY.
RX PubMed=19816106; DOI=10.4161/psb.4.5.8272;
RA Matsuda T., Kuramata M., Takahashi Y., Kitagawa E., Youssefian S.,
RA Kusano T.;
RT "A novel plant cysteine-rich peptide family conferring cadmium tolerance to
RT yeast and plants.";
RL Plant Signal. Behav. 4:419-421(2009).
RN [8]
RP FUNCTION.
RC STRAIN=cv. Nipponbare;
RX PubMed=23888867; DOI=10.1111/tpj.12296;
RA Xia J., Yamaji N., Ma J.F.;
RT "A plasma membrane-localized small peptide is involved in rice aluminium
RT tolerance.";
RL Plant J. 76:345-355(2013).
CC -!- FUNCTION: Confers resistance to heavy metal ions (e.g. aluminium (Al))
CC by chelating them at the plasma membrane of root cells, thus stopping
CC their entry and reducing their accumulation.
CC {ECO:0000269|PubMed:23888867}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5VSB5};
CC Single-pass membrane protein {ECO:0000255}. Secreted, cell wall
CC {ECO:0000250|UniProtKB:Q5VSB5}.
CC -!- TISSUE SPECIFICITY: Mainly expressed in shoots, and, to a lower extent,
CC in roots. {ECO:0000269|PubMed:19017626}.
CC -!- INDUCTION: Down-regulated in root tissues but up-regulated in shoot
CC tissues in response to cadmium (CdCl(2)).
CC {ECO:0000269|PubMed:19017626}.
CC -!- SIMILARITY: Belongs to the CYSTM1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAG87062.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AP008208; BAH91578.1; -; Genomic_DNA.
DR EMBL; AP014958; BAS77575.1; -; Genomic_DNA.
DR EMBL; CM000139; EAZ22179.1; -; Genomic_DNA.
DR EMBL; AK059641; BAG87062.1; ALT_FRAME; mRNA.
DR AlphaFoldDB; A3A4E0; -.
DR STRING; 4530.OS02T0208500-01; -.
DR PRIDE; A3A4E0; -.
DR EnsemblPlants; Os02t0208500-01; Os02t0208500-01; Os02g0208500.
DR Gramene; Os02t0208500-01; Os02t0208500-01; Os02g0208500.
DR eggNOG; ENOG502R5EE; Eukaryota.
DR HOGENOM; CLU_156676_2_0_1; -.
DR InParanoid; A3A4E0; -.
DR OMA; HVRRRHE; -.
DR Proteomes; UP000000763; Chromosome 2.
DR Proteomes; UP000007752; Chromosome 2.
DR Proteomes; UP000059680; Chromosome 2.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009505; C:plant-type cell wall; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; ISS:UniProtKB.
DR GO; GO:0140487; F:metal ion sequestering activity; ISS:UniProtKB.
DR GO; GO:0055079; P:aluminum ion homeostasis; IDA:UniProtKB.
DR GO; GO:1990748; P:cellular detoxification; ISS:UniProtKB.
DR GO; GO:0071585; P:detoxification of cadmium ion; ISS:UniProtKB.
DR GO; GO:0010273; P:detoxification of copper ion; ISS:UniProtKB.
DR GO; GO:0010044; P:response to aluminum ion; IDA:UniProtKB.
DR GO; GO:0046686; P:response to cadmium ion; IEP:UniProtKB.
DR InterPro; IPR028144; CYSTM_dom.
DR Pfam; PF12734; CYSTM; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cell wall; Membrane; Metal-binding; Reference proteome;
KW Secreted; Stress response; Transmembrane; Transmembrane helix.
FT CHAIN 1..60
FT /note="Protein CADMIUM TOLERANCE 4"
FT /id="PRO_0000454818"
FT TRANSMEM 26..42
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 60 AA; 6974 MW; 8CAC1853B9E85420 CRC64;
MDEPSQGGDQ KLSAMEHVKK RHEEKGFLYA CLFMLCCCFC CYETCEHCLE CFCCCCKKDN
