ID   CDTA_CAMJE              Reviewed;         268 AA.
AC   Q0PC56; Q46100;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Cytolethal distending toxin subunit A;
DE            Short=CDT A;
DE   Flags: Precursor;
GN   Name=cdtA; OrderedLocusNames=Cj0079c;
OS   Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC
OS   11168).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=192222;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CH5;
RA   Scott D.A., McVeigh A.L., Pratt C., Lee L., Michielutti R.E., Kinsella N.,
RA   Trust T.J., Guerry P.;
RT   "Coordinate regulation of virulence factors of Campylobacter spp. by bile
RT   salts.";
RL   Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700819 / NCTC 11168;
RX   PubMed=10688204; DOI=10.1038/35001088;
RA   Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M.,
RA   Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S.,
RA   Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A.,
RA   Rajandream M.A., Rutherford K.M., van Vliet A.H.M., Whitehead S.,
RA   Barrell B.G.;
RT   "The genome sequence of the food-borne pathogen Campylobacter jejuni
RT   reveals hypervariable sequences.";
RL   Nature 403:665-668(2000).
CC   -!- FUNCTION: CDTs are cytotoxins which induce cell distension, growth
CC       arrest in G2/M phase, nucleus swelling, and chromatin fragmentation in
CC       HeLa cells. {ECO:0000250}.
CC   -!- SUBUNIT: Heterotrimer of 3 subunits, CdtA, CdtB and CdtC.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}.
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DR   EMBL; AF038283; AAF16678.1; -; Genomic_DNA.
DR   EMBL; AL111168; CAL34252.1; -; Genomic_DNA.
DR   PIR; A81424; A81424.
DR   RefSeq; WP_002852021.1; NC_002163.1.
DR   RefSeq; YP_002343541.1; NC_002163.1.
DR   AlphaFoldDB; Q0PC56; -.
DR   SMR; Q0PC56; -.
DR   STRING; 192222.Cj0079c; -.
DR   PaxDb; Q0PC56; -.
DR   PRIDE; Q0PC56; -.
DR   EnsemblBacteria; CAL34252; CAL34252; Cj0079c.
DR   GeneID; 904406; -.
DR   KEGG; cje:Cj0079c; -.
DR   PATRIC; fig|192222.6.peg.78; -.
DR   eggNOG; ENOG50347HZ; Bacteria.
DR   HOGENOM; CLU_090932_0_0_7; -.
DR   OMA; WGYSARD; -.
DR   PHI-base; PHI:7848; -.
DR   Proteomes; UP000000799; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   CDD; cd00161; RICIN; 1.
DR   InterPro; IPR015957; CDtoxinA.
DR   InterPro; IPR003558; CDtoxinA/C.
DR   InterPro; IPR035992; Ricin_B-like_lectins.
DR   InterPro; IPR000772; Ricin_B_lectin.
DR   Pfam; PF03498; CDtoxinA; 1.
DR   PIRSF; PIRSF036516; CDT_A; 1.
DR   SUPFAM; SSF50370; SSF50370; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR   PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Lectin; Lipoprotein; Membrane; Palmitate;
KW   Reference proteome; Signal; Toxin; Virulence.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           20..268
FT                   /note="Cytolethal distending toxin subunit A"
FT                   /id="PRO_0000013369"
FT   DOMAIN          112..252
FT                   /note="Ricin B-type lectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00174"
FT   REGION          129..140
FT                   /note="Mediates binding to target cells"
FT                   /evidence="ECO:0000250"
FT   LIPID           20
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000305"
FT   LIPID           20
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   268 AA;  29919 MW;  8E130277E8499A74 CRC64;
     MQKIIVFILC CFMTFFLYAC SSKFENVNPL GRSFGEFEDT DPLKLGLEPT FPTNQEIPSL
     ISGADLVPIT PITPPLTRTS NSANNNAANG INPRFKDEAF NDVLIFENRP AVSDFLTILG
     PSGAALTVWA LAQGNWIWGY TLIDSKGFGD ARVWQLLLYP NDFAMIKNAK TNTCLNAYGN
     GIVHYPCDAS NHAQMWKLIP MSNTAVQIKN LGNGKCIQAP ITNLYGDFHK VFKIFTVECA
     KKDNFDQQWF LTTPPFTAKP LYRQGEVR