CDV3_DROME
ID CDV3_DROME Reviewed; 271 AA.
AC Q8MMC4; O16052; Q8SZ44; Q9W0Y3;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Protein CDV3 homolog;
DE AltName: Full=Protein anon-2C9;
GN ORFNames=CG3760;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
RC STRAIN=Canton-S; TISSUE=Embryo;
RX PubMed=9275195; DOI=10.1073/pnas.94.18.9746;
RA Schmid K.J., Tautz D.;
RT "A screen for fast evolving genes from Drosophila.";
RL Proc. Natl. Acad. Sci. U.S.A. 94:9746-9750(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-134, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=A;
CC IsoId=Q8MMC4-1; Sequence=Displayed;
CC Name=B;
CC IsoId=Q8MMC4-2; Sequence=VSP_027764;
CC -!- SIMILARITY: Belongs to the CDV3 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL48749.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF005857; AAB81488.1; -; mRNA.
DR EMBL; AE013599; AAF47296.1; -; Genomic_DNA.
DR EMBL; AE013599; AAM70801.1; -; Genomic_DNA.
DR EMBL; AY071127; AAL48749.1; ALT_FRAME; mRNA.
DR RefSeq; NP_001246513.1; NM_001259584.2. [Q8MMC4-2]
DR RefSeq; NP_611981.2; NM_138137.4. [Q8MMC4-2]
DR RefSeq; NP_726501.1; NM_166700.3. [Q8MMC4-1]
DR AlphaFoldDB; Q8MMC4; -.
DR BioGRID; 63555; 4.
DR IntAct; Q8MMC4; 1.
DR STRING; 7227.FBpp0072299; -.
DR iPTMnet; Q8MMC4; -.
DR PaxDb; Q8MMC4; -.
DR DNASU; 37987; -.
DR EnsemblMetazoa; FBtr0072391; FBpp0072298; FBgn0022343. [Q8MMC4-2]
DR EnsemblMetazoa; FBtr0072392; FBpp0072299; FBgn0022343. [Q8MMC4-1]
DR EnsemblMetazoa; FBtr0309242; FBpp0301181; FBgn0022343. [Q8MMC4-2]
DR GeneID; 37987; -.
DR KEGG; dme:Dmel_CG3760; -.
DR UCSC; CG3760-RA; d. melanogaster. [Q8MMC4-1]
DR FlyBase; FBgn0022343; CG3760.
DR VEuPathDB; VectorBase:FBgn0022343; -.
DR eggNOG; ENOG502S35X; Eukaryota.
DR InParanoid; Q8MMC4; -.
DR PhylomeDB; Q8MMC4; -.
DR BioGRID-ORCS; 37987; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 37987; -.
DR PRO; PR:Q8MMC4; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0022343; Expressed in wing disc and 23 other tissues.
DR ExpressionAtlas; Q8MMC4; baseline and differential.
DR Genevisible; Q8MMC4; DM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR InterPro; IPR026806; CDV3.
DR PANTHER; PTHR16284; PTHR16284; 1.
DR Pfam; PF15359; CDV3; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..271
FT /note="Protein CDV3 homolog"
FT /id="PRO_0000299568"
FT REGION 37..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..89
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..151
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..246
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 134
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT VAR_SEQ 100..105
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000303|PubMed:9275195"
FT /id="VSP_027764"
FT CONFLICT 173
FT /note="H -> P (in Ref. 1; AAB81488)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 271 AA; 29636 MW; 492104BA68AD97AA CRC64;
MAELDDFFAK KDKKKSKNKT KFVTADEMVK NLEDGTKREV VKPKKPEVAA GGVAVVGENE
NSGTKVPESA PPVEEEWKEF EEEQRKDYSG LKIGQLSTIS SARSRTAQES SESQAARVPS
APDGGNYNED DEDSNGYDNA DVNKERVGHG PWKKVVPAEE VMQIPVPVEV EKHSSKTYVS
PALRYSQQAG SGLGGGPTGG ALRPRRAAPD ITNTEFFPTL SAARPEEQRK KKNEPAFEEV
RHGSRFQRVQ ESTAAPVAAS NRFQSLDDEA S
