ID   CDVA_SULAC              Reviewed;         238 AA.
AC   Q4J923;
DT   18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Cell division protein A {ECO:0000305};
GN   Name=cdvA {ECO:0000303|PubMed:18987308};
GN   OrderedLocusNames=Saci_1374 {ECO:0000312|EMBL:AAY80708.1};
OS   Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC
OS   15157 / NCIMB 11770).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfolobus.
OX   NCBI_TaxID=330779;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770;
RX   PubMed=15995215; DOI=10.1128/jb.187.14.4992-4999.2005;
RA   Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E.,
RA   Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.;
RT   "The genome of Sulfolobus acidocaldarius, a model organism of the
RT   Crenarchaeota.";
RL   J. Bacteriol. 187:4992-4999(2005).
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, AND INDUCTION.
RC   STRAIN=ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770;
RX   PubMed=18987308; DOI=10.1073/pnas.0809467105;
RA   Lindaas A.C., Karlsson E.A., Lindgren M.T., Ettema T.J., Bernander R.;
RT   "A unique cell division machinery in the Archaea.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:18942-18946(2008).
RN   [3]
RP   FUNCTION, INTERACTION WITH CDVB, SUBCELLULAR LOCATION, DOMAIN, AND
RP   MUTAGENESIS OF VAL-232 AND VAL-234.
RC   STRAIN=ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770;
RX   PubMed=21255729; DOI=10.1016/j.molcel.2010.12.018;
RA   Samson R.Y., Obita T., Hodgson B., Shaw M.K., Chong P.L., Williams R.L.,
RA   Bell S.D.;
RT   "Molecular and structural basis of ESCRT-III recruitment to membranes
RT   during archaeal cell division.";
RL   Mol. Cell 41:186-196(2011).
CC   -!- FUNCTION: Part of a cell division machinery (PubMed:18987308,
CC       PubMed:21255729). The CdvA, CdvB and CdvC proteins polymerize between
CC       segregating nucleoids and persist throughout cell division, forming a
CC       successively smaller structure during constriction (PubMed:18987308).
CC       CdvA is a membrane interacting protein that recruits ESCRT-III homologs
CC       to the membrane (PubMed:21255729). {ECO:0000269|PubMed:18987308,
CC       ECO:0000269|PubMed:21255729}.
CC   -!- SUBUNIT: Interacts with CdvB. {ECO:0000269|PubMed:21255729}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid
CC       {ECO:0000269|PubMed:18987308}. Cell membrane
CC       {ECO:0000305|PubMed:21255729}; Peripheral membrane protein
CC       {ECO:0000305|PubMed:21255729}. Note=Forms, with CdvB, colocalized band-
CC       like structures between segregating nucleoids.
CC       {ECO:0000269|PubMed:18987308}.
CC   -!- INDUCTION: Induced around the genome segregation and cell division
CC       stages. Down-regulated after UV irradiation, indicating division
CC       inhibition in response to DNA damage. {ECO:0000269|PubMed:18987308}.
CC   -!- DOMAIN: The C-terminal 18 residues mediate the interaction with the wH-
CC       like region of CdvB. {ECO:0000269|PubMed:21255729}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000077; AAY80708.1; -; Genomic_DNA.
DR   RefSeq; WP_011278210.1; NC_007181.1.
DR   AlphaFoldDB; Q4J923; -.
DR   SMR; Q4J923; -.
DR   STRING; 330779.Saci_1374; -.
DR   TCDB; 3.A.31.1.3; the endosomal sorting complexes required for transport iii (escrt-iii) family.
DR   EnsemblBacteria; AAY80708; AAY80708; Saci_1374.
DR   GeneID; 3472939; -.
DR   KEGG; sai:Saci_1374; -.
DR   PATRIC; fig|330779.12.peg.1326; -.
DR   eggNOG; arCOG04054; Archaea.
DR   HOGENOM; CLU_100857_0_0_2; -.
DR   OMA; MIAVKMS; -.
DR   Proteomes; UP000001018; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR041461; CdvA_CC.
DR   Pfam; PF18822; CdvA; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Cell membrane; Cytoplasm; Membrane;
KW   Reference proteome.
FT   CHAIN           1..238
FT                   /note="Cell division protein A"
FT                   /id="PRO_0000438765"
FT   MUTAGEN         232
FT                   /note="V->D: Loss of interaction with CdvB; when associated
FT                   with D-234."
FT                   /evidence="ECO:0000269|PubMed:21255729"
FT   MUTAGEN         234
FT                   /note="V->D: Loss of interaction with CdvB; when associated
FT                   with D-232."
FT                   /evidence="ECO:0000269|PubMed:21255729"
SQ   SEQUENCE   238 AA;  27076 MW;  757F94ED037BE1DF CRC64;
     MGIPVEVLTK FIGQKVKDVY GRDAGVIVHV YTEIDGTITG IELFKGEEIK TYSPNSVKVD
     GDSVVILPDW KTDSLKVLGQ MEKIRKRQRA LEELYSRQEI PKSTYEDMKR KLDSELLKIR
     DEHSRLKGRL KDRLNSIEDQ VAQIDRAMIA LKINYISGEI PELAYKNSME ILRLSRDSYA
     LERDDIKKTL DKLDGLDKEV IELKPSASLN TSTEQSNKNE GNKSEVSVPI PVRVINTL