ID   CDX1_CHICK              Reviewed;         260 AA.
AC   Q9DEB6;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 2.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Homeobox protein CDX-1;
DE   AltName: Full=Caudal-type homeodomain protein;
GN   Name=CDX1; Synonyms=CDXA;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Ishii Y.;
RT   "Gallus gallus caudal-type homeodomain protein (CdxA) mRNA.";
RL   Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in transcriptional regulation. Involved in
CC       activated KRAS-mediated transcriptional activation of PRKD1. Binds to
CC       the PRKD1 promoter. Could play a role in the terminal differentiation
CC       of the intestine. Binds preferentially to methylated DNA.
CC       {ECO:0000250|UniProtKB:P47902}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Caudal homeobox family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB18778.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB046532; BAB18778.1; ALT_INIT; mRNA.
DR   RefSeq; NP_990007.2; NM_204676.2.
DR   AlphaFoldDB; Q9DEB6; -.
DR   SMR; Q9DEB6; -.
DR   STRING; 9031.ENSGALP00000009094; -.
DR   PaxDb; Q9DEB6; -.
DR   Ensembl; ENSGALT00000009108; ENSGALP00000009094; ENSGALG00000005679.
DR   GeneID; 395397; -.
DR   KEGG; gga:395397; -.
DR   CTD; 1044; -.
DR   VEuPathDB; HostDB:geneid_395397; -.
DR   eggNOG; KOG0848; Eukaryota.
DR   GeneTree; ENSGT00940000164078; -.
DR   HOGENOM; CLU_073177_1_0_1; -.
DR   InParanoid; Q9DEB6; -.
DR   OMA; DKDTNMY; -.
DR   OrthoDB; 1380804at2759; -.
DR   PhylomeDB; Q9DEB6; -.
DR   TreeFam; TF351605; -.
DR   PRO; PR:Q9DEB6; -.
DR   Proteomes; UP000000539; Chromosome 13.
DR   Bgee; ENSGALG00000005679; Expressed in colon.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008327; F:methyl-CpG binding; ISS:UniProtKB.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR   GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR   GO; GO:0009948; P:anterior/posterior axis specification; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR006820; Caudal_activation_dom.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF04731; Caudal_act; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..260
FT                   /note="Homeobox protein CDX-1"
FT                   /id="PRO_0000253462"
FT   DNA_BIND        149..208
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          152..173
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250|UniProtKB:P47902"
FT   REGION          191..202
FT                   /note="Interaction with 5-mCpG DNA"
FT                   /evidence="ECO:0000250|UniProtKB:P47902"
FT   REGION          204..260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   260 AA;  28844 MW;  8B77AA66D693CFA2 CRC64;
     MYVGYLLDKD TNMYPSPVRH PSLNLNPQNY VPGPPQYSDF ASYHHVPGIN NDPHHGQPAA
     AWGSPYTPAK EDWHSYGTAA ASAATNPGQF GFSPPDFNPM QPHAGSGLLP PAISSSVPQL
     SPNAQRRTPY EWMRRSIPST SSSGKTRTKD KYRVVYTDHQ RLELEKEFHY SRYITIRRKA
     ELAAALGLTE RQVKIWFQNR RAKERKVNKK KLQQQSQPTS TTTPTPPAVG TPGPMGTLCS
     GSAPSLVSSS PLTIKEEFMP