ID   CDX1_RAT                Reviewed;         123 AA.
AC   Q05095;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 129.
DE   RecName: Full=Homeobox protein CDX-1;
DE   AltName: Full=Caudal-type homeobox protein 1;
DE   Flags: Fragment;
GN   Name=Cdx1; Synonyms=Cdx-1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Intestine;
RX   PubMed=1360907; DOI=10.1016/0014-5793(92)80965-j;
RA   Freund J.-N., Boukamel R., Benazzouz A.;
RT   "Gradient expression of Cdx along the rat intestine throughout postnatal
RT   development.";
RL   FEBS Lett. 314:163-166(1992).
CC   -!- FUNCTION: Plays a role in transcriptional regulation. Involved in
CC       activated KRAS-mediated transcriptional activation of PRKD1 in
CC       colorectal cancer (CRC) cells. Binds to the PRKD1 promoter in
CC       colorectal cancer (CRC) cells. Could play a role in the terminal
CC       differentiation of the intestine. Binds preferentially to methylated
CC       DNA. {ECO:0000250|UniProtKB:P47902}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Intestinal epithelium.
CC   -!- SIMILARITY: Belongs to the Caudal homeobox family. {ECO:0000305}.
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DR   EMBL; M91450; AAA40907.1; -; Genomic_DNA.
DR   PIR; S27397; S27397.
DR   AlphaFoldDB; Q05095; -.
DR   SMR; Q05095; -.
DR   STRING; 10116.ENSRNOP00000025141; -.
DR   UCSC; RGD:621233; rat.
DR   RGD; 621233; Cdx1.
DR   eggNOG; KOG0848; Eukaryota.
DR   InParanoid; Q05095; -.
DR   PhylomeDB; Q05095; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0008327; F:methyl-CpG binding; ISS:UniProtKB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR   GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR   GO; GO:0009948; P:anterior/posterior axis specification; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; ISO:RGD.
DR   GO; GO:0060349; P:bone morphogenesis; ISO:RGD.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0007389; P:pattern specification process; ISO:RGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0014807; P:regulation of somitogenesis; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           <1..123
FT                   /note="Homeobox protein CDX-1"
FT                   /id="PRO_0000048848"
FT   DNA_BIND        5..64
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          8..29
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250|UniProtKB:P47902"
FT   REGION          47..58
FT                   /note="Interaction with 5-mCpG DNA"
FT                   /evidence="ECO:0000250|UniProtKB:P47902"
FT   REGION          57..123
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   123 AA;  14300 MW;  3A23B89584FA2777 CRC64;
     KTRTKDKYRV VYTDHQRLEL EKEFHYSRYI TIRRKSELAA NLGLTERQVK IWFQNRRAKE
     RKVNKKKQQQ QQQQQQQPMP PTQLPLPLDG TPTPSGHPGS LCPTNAGLLG TPSPVPVKEE
     FLP