ID   CDX1_XENLA              Reviewed;         263 AA.
AC   Q91622;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Homeobox protein CDX-1;
DE            Short=xCAD2;
GN   Name=cdx1; Synonyms=cad2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Tram W., Inoue K., Blumberg B., Cho K.W.Y.;
RT   "Xenopus Xcad2 is a homolog of chicken CHox-cad.";
RL   Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in transcriptional regulation. Involved in
CC       activated KRAS-mediated transcriptional activation of PRKD1. Binds to
CC       the PRKD1 promoter. Could play a role in the terminal differentiation
CC       of the intestine. Binds preferentially to methylated DNA.
CC       {ECO:0000250|UniProtKB:P47902}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Caudal homeobox family. {ECO:0000305}.
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DR   EMBL; U04302; AAA03642.1; -; mRNA.
DR   PIR; A40856; A40856.
DR   RefSeq; NP_001081175.1; NM_001087706.1.
DR   AlphaFoldDB; Q91622; -.
DR   SMR; Q91622; -.
DR   GeneID; 397695; -.
DR   KEGG; xla:397695; -.
DR   CTD; 397695; -.
DR   Xenbase; XB-GENE-864834; cdx1.S.
DR   OrthoDB; 1227444at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 397695; Expressed in intestine and 2 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008327; F:methyl-CpG binding; ISS:UniProtKB.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR006820; Caudal_activation_dom.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF04731; Caudal_act; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..263
FT                   /note="Homeobox protein CDX-1"
FT                   /id="PRO_0000253463"
FT   DNA_BIND        150..209
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          47..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          153..174
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250|UniProtKB:P47902"
FT   REGION          192..203
FT                   /note="Interaction with 5-mCpG DNA"
FT                   /evidence="ECO:0000250|UniProtKB:P47902"
FT   REGION          204..263
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        81..99
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..254
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   263 AA;  29201 MW;  A950FF028BD1EFE5 CRC64;
     MYVGYLLDKD NNMYPNPVRH PGLNLNPQNY VPAPPQYSDF PSYHHVPGIN SDPHHGQPGG
     TWSSYTPSRE DWHPYGPGPG ASSANPTQIA FSPSDYNPVQ PPGSGLLPPS INSSVPPLSP
     SAQRADPYEW MRRTGVPTTT TTTNGKTRTK DKYRVVYTDH QRLELEKEFH YSRYITIRRK
     AELAAALGLT ERQVKIWFQN RRAKERKVNK KKMQQQSQQA STTTPTPPSV GTTAGMGGLC
     SSSSSNSNLV SPSSMPIKEE YLS