ID   CDX1_XENTR              Reviewed;         262 AA.
AC   Q90X89;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Homeobox protein CDX-1;
GN   Name=cdx1; Synonyms=cad2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=11803576; DOI=10.1002/dvdy.1234.abs;
RA   Reece-Hoyes J.S., Keenan I.D., Isaacs H.V.;
RT   "Cloning and expression of the Cdx family from the frog Xenopus
RT   tropicalis.";
RL   Dev. Dyn. 223:134-140(2002).
CC   -!- FUNCTION: Plays a role in transcriptional regulation. Involved in
CC       activated KRAS-mediated transcriptional activation of PRKD1. Binds to
CC       the PRKD1 promoter. Could play a role in the terminal differentiation
CC       of the intestine. Binds preferentially to methylated DNA.
CC       {ECO:0000250|UniProtKB:P47902}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DEVELOPMENTAL STAGE: Expressed around the blastopore through gastrula
CC       stages. Expressed in the neural tube (posterior dorsal neuroectoderm
CC       and the posterior ventral ectoderm) at late neurula stage 20. Expressed
CC       in the posterior tip of the neural tube and the posterior wall of the
CC       neuroenteric canal at tail bud stage 30. Expressed in the developing
CC       gut at stage 40. {ECO:0000269|PubMed:11803576}.
CC   -!- SIMILARITY: Belongs to the Caudal homeobox family. {ECO:0000305}.
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DR   EMBL; AF417198; AAL14633.1; -; mRNA.
DR   RefSeq; NP_989416.1; NM_204085.1.
DR   AlphaFoldDB; Q90X89; -.
DR   SMR; Q90X89; -.
DR   STRING; 8364.ENSXETP00000004606; -.
DR   PaxDb; Q90X89; -.
DR   GeneID; 395055; -.
DR   KEGG; xtr:395055; -.
DR   CTD; 1044; -.
DR   Xenbase; XB-GENE-485396; cdx1.
DR   eggNOG; KOG0848; Eukaryota.
DR   InParanoid; Q90X89; -.
DR   OrthoDB; 1380804at2759; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008327; F:methyl-CpG binding; ISS:UniProtKB.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR   GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR   GO; GO:0009948; P:anterior/posterior axis specification; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR006820; Caudal_activation_dom.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF04731; Caudal_act; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..262
FT                   /note="Homeobox protein CDX-1"
FT                   /id="PRO_0000253464"
FT   DNA_BIND        149..208
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          42..120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          152..173
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250|UniProtKB:P47902"
FT   REGION          191..202
FT                   /note="Interaction with 5-mCpG DNA"
FT                   /evidence="ECO:0000250|UniProtKB:P47902"
FT   REGION          203..262
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        212..253
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   262 AA;  29201 MW;  678E4375C371A210 CRC64;
     MYVGYLLDKD NNMYPNPVRH PGLNLNPQNY VPAPPQYSDF PSYHHVPGIN SDPHHGQPGG
     TWSSYTPSRE DWHPYGPGPG ASSANPAQIS FSPSDYNPVQ PPGPGLLPPS LNSSVSPLSP
     SAQRRNLYEW MRRTGVPTST NSNGKTRTKD KYRVVYTDHQ RLELEKEFHY SRYITIRRKA
     ELAASLALTE RQVKIWFQNR RAKERKVNKK KMQQQSQQAS TTTPTPPSVG TTAGMGGLCS
     SSSSNSNLVS PSSMPIKEEY LS